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Dear all, I am done with this platform, I will cancel my account today.
I will be on LinkedIn to continue disseminating my research!
Thanks to every single one of you that supported, liked, and shared our research!
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Panagiotis Kastritis
604 posts
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Crosslinks can sometimes improve AlphaFold3 models. Crosslinking is an experimental method often used as a source of distance restraints in modeling. In AlphaFold3, instead of using restraints, crosslinks can be included as covalent ligands. Thanks to @aobarska for the idea.
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A fully funded Phd studentship is available in collaboration with the groups of Graham Pavitt and Alan Roseman at the university of Manchester:
findaphd.com/phds/project/b…
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▶️ We will be hiring soon! 12 PhD student positions will be available in our #RTG2467 @unihalle @dfg_public. If you are interested in intrinsically disordered proteins #idps you are in the right place here. 🥳 Please stay tuned!
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Ever wondered if nuclear pore architecture and function changes during germ cell differentiation? In human spermatogenesis it does, and radically!!
Check out our first lab preprint @AliaCSantos et al! biorxiv.org/content/10.110…
@PiotrKolata1 @AlisterBurt @TDendooven @MRC_LMB
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Friendly reminder that if you want to contribute to science, release your code/models. Not (just) a server with 10 daily jobs. A system like AlphaFold —built on "public goods" provided for free— must be equally open to the scientific community in response
pubmed.ncbi.nlm.nih.gov/33984281/
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Excited to share our latest research on co-translational mRNA decay by the exosome in human cells! We uncover how the exosome-SKI complex is recruited to ribosomes and propose a novel role for SKI in recognizing collided disomes. @MPI_Biochem
👇👇👇
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University of Washington biochemist David Baker has won the 2024 Nobel Prize in Chemistry for his pioneering work designing new proteins that can neutralize viruses, target cancer cells, and more.
Read more from @uwmedicine: go.uw.edu/2024NobelPrize
#NobelPrize #GoHuskies
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It's a good week! Two papers out, one accepted (see thread below), and the @BioExcelCoE @UUBeta @EoscPortal web server passed the cap of 50'000 registered users! rascar.science.uu.nl/new/stats
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The final version of our PyShell🥧🐚 paper is now online @CellCellPress. Check out how diatoms soak up 20% of the Earth's #CO2!🌏
📜 sciencedirect.com/science/articl…
Brilliant work by @DemulderManon, @Jorgendottir, Ginga, Aki, Giovanni, Genji, Yusuke, and all the rest of our collabs 🤗
Ben Engel@bengeliscious
Meet the PyShell!🥧🐚 Diatom pyrenoids fix up to 20% of the Earth's #CO2🌏. We discovered that their Rubisco is encased in a tight protein lattice that is essential for efficient carbon fixation and cell growth🌱 Super excited to share our new preprint📜: biorxiv.org/content/10.110…
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@GlattSebastian @VetmeduniVienna Congratulations Sebastian!!! Incredible news! I wish the best for the new position in your home town!
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Now it's official - I have accepted a full professorship for Systems Genetics @VetmeduniVienna...and today is my first day. I am very much looking forward to becoming part of the excellent RNA and structural biology community in Austria. Exciting times ahead!
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Panagiotis Kastritis @3Dstructure @EIEgr joins us remotely to describe the "hot4cryo" project which seeks to establish the first and only cryo-EM in South East Europe @HorizonEU
Two @instructhub countries Greece and Germany working together through knowledge transfer
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Happy to share our latest work identifying a role for IQD-KLCR in plasma membrane-microtubule tethering and plant mechanostress-mediated microtubule reorganization. Long in the making and finally out @biorxivpreprint. biorxiv.org/content/10.110…
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Low-dose cryo-electron ptychography of proteins at sub-nanometer resolution via @StephanieRibet @ColinOphus @g_varnavides @LabStahlberg nature.com/articles/s4146…
wooooohoooooooooooo ❄️❄️👶
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No way! 🤯 The Baker lab will have a podcast about biology, chemistry and AI!
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Vom Chaos zur Ordnung: Wie das Protein "MIPS" seine Struktur ändert, wenn es aktiv wird, haben Forschende um Prof. Dr. Panagiotis Kastritis erstmals beobachten können. Das Protein ist wichtig bei der Produktion von Inositol, besser bekannt als Vitamin B8. pressemitteilungen.pr.uni-halle.de/index.php?modu…
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We're pumped to announce that Foldseek search is now live in the AlphaFold database! 🎉
You can explore similar structures in PDB and AFDB50 directly on each protein entry, along with the Foldseek clusters!
Thanks to our awesome collaborators at @thesteinegger lab!
EMBL-EBI@emblebi
🚀New update to #AlphaFold Database: Foldseek now integrated! Peer deeper into evolution with new structure-based search feature to find similar proteins with remote homology. The search includes experimentally-determined protein structures from @PDBe. ebi.ac.uk/about/news/upd…
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The AlphaLink2 paper is now online! It’s joint work with @rbolab and @JorgStulke. AlphaLink2 integrates crosslinking MS data into AlphaFold-Multimer. AlphaLink2 really shines for challenging targets like antigen-antibody complexes. doi.org/10.1038/s41467…
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Beautiful work on the in situ structure of ATP Synthase by @dietrich_th from the Kühlbrandt group published today in @ScienceMagazine 🔬 Discover how this important protein complex shapes the inner mitochondrial membrane! 🧪
science.org/doi/10.1126/sc…
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