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Join @AniMichaud1 on a tour of the Bement lab @UWMadison and see what we're all about! #CellBiology
youtu.be/it0aRx8-0Vo
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Bement Lab
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Bement Lab
@BementLab
Transient contractile arrays. Part of the Center for Quantitative Cell Imaging (@UWCQCI) at UW-Madison. Tweets mostly by @ZacSwider and @AniMichaud1.
Madison, Wisconsin Bergabung Mart 2019
213 Mengikuti707 Pengikut
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Any #microscopy friends have any suggestions for a water stage cooler/pump? I'm specifically interested in something to slowly flow water through a light sheet imaging chamber so it will need a very slow and consistent flow rate. Maybe @ZakSwartz ?
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Very much like the Belousov-Zhabotinsky reaction: youtube.com/watch?v=jRQAnd…
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Bement Lab@BementLab
Light sheet imaging with @henryhetired and @spim revealed that these patterns were wide-spread and well-developed at merely 5hrs post-mRNA injection. This behavior was not seen with GAP-dead RGA or another cytokinetic GAP (p190RhoGAP).
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This 🧵.. wow!
Bement Lab@BementLab
Our latest pre-print is up on @bioRxiv! Here, @AniMichaud1 et al. identified Ect2 and RGA-3/4 as core components of cytokinetic cortical excitability. We also show that immature Xenopus oocytes are a powerful model for characterizing excitability. A 🧵... biorxiv.org/content/10.110…
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@joachimgoedhart That’s usually what we look like in the microscope room 😵💫
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Super cool new preprint from
@AniMichaud1, @BementLab, et al. on cytoskeletal waves in frog & starfish embryos. Wonder if one could see this in zebrafish…
“A versatile pattern-forming cortical circuit based on Rho, F-actin, Ect2 and RGA-3/4”
biorxiv.org/content/10.110…
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How does RGA get recruited to cortical waves and what exactly is the nature of its relationship with F-actin? We aren't sure, but we plan to use immature frog oocytes and modeling to address these questions!
GIF
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Modeling and experiments showed that Ect2 and RGA-3/4 are major drivers of this circuit, and just altering the relative levels of these two players produced a variety of cortical behaviors in an otherwise quiescent oocyte cortex!
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Our latest pre-print is up on @bioRxiv! Here, @AniMichaud1 et al. identified Ect2 and RGA-3/4 as core components of cytokinetic cortical excitability. We also show that immature Xenopus oocytes are a powerful model for characterizing excitability. A 🧵...
biorxiv.org/content/10.110…
English