Cornall_lab

67 posts

Cornall_lab

@CornallLab

Bergabung Eylül 2018

96 Mengikuti92 Pengikut

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Mukta Deobagkar@MDeobagkar·12 Ağu

Check out our new @SciImmunology paper about the role of DOCK8 in the survival and differentiation of B cells activated by low amounts of antigen: doi.org/10.1126/sciimm… A big shoutout to @CornallLab & @BetterKidneys Thank you @MRC_TIDU @HumanGeneticsOx @NDMOxford @CAMS_COI_Ox

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Waggoner Lab@LabWaggoner·9 Ağu

B cells activated by low amounts of antigen require DOCK8 to acquire survival and differentiation signals via T cell help @SciImmunology @CornallLab science.org/doi/10.1126/sc…

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Katherine Bull@BetterKidneys·12 Haz

Exciting postdoc role with our friendly supportive group and @trig_oxford @fgissa. Cell therapy for IgA Nephropathy, part of EU /Horizon consortium. Do you like immunology, kidneys and translational research? Informal enquires / DMs for more info welcome my.corehr.com/pls/uoxrecruit…

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Dr Lucy Garner@TheLucyGarner·14 Ağu

I am really excited to announce that our paper (@PKlenermanLab) exploring MAIT cell transcriptional and TCR repertoire diversity in human blood and liver has been released @NatImmunol nature.com/articles/s4159… #MAITcells

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Immunotherapy Advances Journal@IMTadvances·16 May

Researchers at @DavisLab_Oxford investigate the potential of a new combination #immunotherapy of #nivolumab, a clinically approved #PD1 blocking antibody, & OX108, a #CD200R blocker Explore their results in mouse models for colorectal & lung #cancer ➡️bit.ly/3Madlmm

Immunotherapy Advances Journal tweet media

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Martin Fellermeyer@MFellermeyer·1 Nis

Very pleased to have my first PhD publication published in @IMTadvances. Using humanised mice we trialled the combination immunotherapy of nivolumab and OX108 (a CD200R blocker) in two tumour models. @DavisLab_Oxford @CornallLab @MRC_HIU @MRC_WIMM @RDMOxford

Immunotherapy Advances Journal@IMTadvances

Our latest article explores the potential of a combination #immunotherapy comprising #Nivolumab, a clinically approved #PD1 blocking antibody, & OX108, a CD200R antagonist, in mouse models for colorectal & lung #cancer Explore the results ➡️bit.ly/3nCdUwU

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The Journal of Immunology@J_Immunol·23 Şub

#AuthorChoice: Prolidase deficiency causes spontaneous #Tcell activation and #lupus-like #autoimmunity | from @BetterKidneys @UniofOxford #FreetoRead #ReadTheJI #immunology 👉 ow.ly/Cmxo50MVZOF

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Katherine Bull@BetterKidneys·13 Oca

Thanks also to: Tanya Crockford, Aneesha Bhandari, @JessKepple, Jenny Back, Eleanor Cawthorne, Lucie Abeler-Dorner, Adam Laing, Simon Clare, Annie Speak, @David_J_Adams @GordonDougan1 @HaydayLab @MDeobagkar @CornallLab @HumanGeneticsOx @OxfordGenomics

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Katherine Bull@BetterKidneys·13 Oca

Beautiful T cell single cell analysis by Rose Hodgson shows increased effectors and significant reduction in Ly6c2+ central effector memory.

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Katherine Bull@BetterKidneys·13 Oca

Chimeric experiments highlight a population of KLRG1+ effector T cells, only observed in association with the autoimmune phenotype.

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Cornall_lab@CornallLab·14 Oca

We demonstrate that the autoimmune phenotype is associated with a populations of effector CD8 T cells with a phenotype similar to short lived effector cells (SLEC) in viral infection. Read on to find out more: journals.aai.org/jimmunol/artic… @BetterKidneys

Katherine Bull@BetterKidneys

Chimeric experiments highlight a population of KLRG1+ effector T cells, only observed in association with the autoimmune phenotype.

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Cornall_lab@CornallLab·14 Oca

Just published! Prolidase deficient mice have increased incidence of anti-nuclear antibodies, immune complex deposition and altered T cell population composition. journals.aai.org/jimmunol/artic…

Katherine Bull@BetterKidneys

Delighted to share our paper on autoimmunity due to prolidase deficiency. We confirm loss of PEPD results in ANAs and renal immune complex deposition, assoc with T cell activation. journals.aai.org/jimmunol/artic…

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Katherine Benjamin@kfbenjamin·14 Ara

I’m completely thrilled to share our new preprint! Multiscale topology classifies and quantifies cell types in subcellular spatial transcriptomics arxiv.org/abs/2212.06505 Joint work with Aneesha Bhandari, @BGI_Genomics, Ulrike Tillmann, @BetterKidneys, and @haharrington 1/9

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Katherine Bull@BetterKidneys·24 Kas

Our lab and @CornallLab giving some thanks

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Katherine Bull@BetterKidneys·11 Kas

NDRG1 is a target for cancer treatment. But it was also thought to help immune cells 'switch off', so NDRG1 drugs might cause immune over-activity. However we show that although NDRG1 goes up in these immune cells, they don't need NDRG1 to switch off. rdcu.be/cZska

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Katherine Bull@BetterKidneys·11 Kas

Our new paper: NDRG1 is an anti cancer therapeutic target, upregulated in anergic B cells, and previously described as a T cell anergy factor, but we show it is not required for B or T cell tolerance. work led by Rose Hodgson, with @CornallLab @NDMOxford rdcu.be/cZska

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Mukta Deobagkar@MDeobagkar·29 Eyl

Fantastic talks and fabulous science at the Oxford Imaging Symposium 2022 today!

Anjali Kusumbe@KusumbeLab

Oxford Imaging Symposium 2022 Programme @MRC_HIU @MRC_WIMM

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Katherine Bull@BetterKidneys·21 Eyl

Looking forward to applying this to DKD with @JessKepple

CAMS Oxford Institute@CAMS_COI_Ox

Exciting times as @nanostringtech training underway on the GeoMx platform in the COI - first slides analysed and sequencing prep planned for tomorrow! #scienceisgreat #dsp

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Dr Emily Thornton@emilyethornton·16 Eyl

I dunno, you guys. It seems like the "B is for Boring" slogan might have been a campaign funded by Big B Cell. Those guys are up to some nefarious stuff! nature.com/articles/s4159… Anyway, T cells to the rescue!

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Katherine Bull@BetterKidneys·1 Ağu

Congratulations Dr Rose Hodgson! Was an absolute pleasure to have you in the lab, already missing the fancy dress @CornallLab @HumanGeneticsOx

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Jelajahi

@SciImmunology @BetterKidneys @MRC_TIDU @HumanGeneticsOx @NDMOxford @CAMS_COI_Ox @trig_oxford @fgissa