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Fromme Lab@Fromme_Lab·6 Oca

Excited to start 2026 out with a new manuscript from our lab, please check out this thread from superstar postdoc @ryan_vignogna about how he discovered the function of a conserved secretory protein, and how this also led him to the identification of a new family of GAP proteins!

Ryan Vignogna@ryan_vignogna

Mind the GAP 🚧🕳️🚧 Excited to share the latest preprint from the @Fromme_Lab showing that the DENN domain protein Avl9 functions as an Arf-GAP, revising long-standing assumptions about DENN protein function, 🧵: biorxiv.org/content/10.648…

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Dr. Liz Miller@LizMillerCU·13 Kas

Really proud of this paper just out in JCB. At almost every turn, SURF4 surprised us. Amazing PhD student, @jmaldutyte, sleuthed it out. rupress.org/jcb/article/22…

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Fromme Lab@Fromme_Lab·31 Eki

created by the multi-talented @ryan_vignogna

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Fromme Lab@Fromme_Lab·31 Eki

Happy Halloween! #GhostlyGolgi

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Fromme Lab@Fromme_Lab·4 Eki

Awesome new paper from @Fran_Bottanelli lab!

Cell Biology J-Club@cell_club

ARF1 compartments direct cargo flow via maturation into recycling endosomes nature.com/articles/s4155…

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Columbia Medicine@ColumbiaMed·18 Eyl

Columbia will award the 2024 Louisa Gross Horwitz Prize to Scott Emr and Wesley Sundquist for discovering the ESCRT pathway and revealing how it works. Read more: columbiamed.link/47uD4jS

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Cornell MBG@CornellMBG·17 Eyl

Excited to announce an MBG faculty search for two assistant professor positions in collaboration with the Weill Institute for Cell and Molecular Biology, @weillinstitute. Please share and apply! academicjobsonline.org/ajo/jobs/28336

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Marcus Smolka@MarcusSmolka·8 Tem

New preprint. More on non-canonical motifs for DDR kinases. Here we find that Tel1 (yeast ATM) targets D/E-S/T. ... more prevalent than S/T-Q ... NOT shared with Mec1. May explain how Tel1 plays specialized roles in DNA repair and telomere maintenance. biorxiv.org/content/10.110…

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Fromme Lab@Fromme_Lab·26 Haz

Big congratulations to @ryan_vignogna on his NIH F32 Postdoctoral Fellowship award!!!

Ryan Vignogna@ryan_vignogna

F32 NOA ✔️ Very grateful for mentors @jcfromme & @gregoryianlang and thankful to work in such an awesome place @weillinstitute @Fromme_Lab

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Jeremy Baskin@basktastic·11 Haz

Final version of our latest Kramer story is out! Congrats to @Hongyan_S for leading this effort & Adnan, Dylan, Alessandro, & @nicobuchon too! Read on to learn how Wnt signaling in surprisingly many cell types promotes stem cell proliferation in the gut: sciencedirect.com/science/articl…

Jeremy Baskin@basktastic

New preprint: It's about a gene called Kramer 😉 that controls #WntSignaling & stem cell proliferation in the fruit fly intestine. Congrats to @Hongyan_S @weillinstitute & @nicobuchon @cornellento @cihmid! cc: @SeinfeldTV @Seinfeld2000 @JerrySeinfeld doi.org/10.1101/2023.0… 1/n

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Fromme Lab@Fromme_Lab·7 Haz

Super impressive membrane-bound Arf1-AP3 cryoEM structures from the Baker lab!🤩

Rick Baker@therickybaker

Check out the latest work from my lab, courtesy of soon-to-be Dr. @Biochem_Batman , who determined multiple #cryoEM structures of the human AP-3 adaptor complex. This was a years-long effort to reconstitute active Arf1-AP3 complexes on lipid nanodiscs biorxiv.org/content/10.110…

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Fromme Lab@Fromme_Lab·26 May

lab alum @FeathersRyan is a DRaGoN master

Ellen Zhong@ZhongingAlong

Dream team Rish and @FeathersRyan giving a cryoDRGN❄️🐉 lecture and tutorial at #CryoNet in Stockholm! 🤩

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〰Gunther Hollopeter@guntherwho·24 May

Happy to share the newest preprint from @HollopeterLab @cornellvet: biorxiv.org/cgi/content/sh…. We propose the Inversin complex works via a dimerization mechanism. You’re probably thinking, “What the $%@! is the Inversin complex?” Let me explain:

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Ryan Feathers@FeathersRyan·10 May

I'm so excited to finally share the results of my PhD work! Check out this thread for all of the highlights! Ric1-Rgp1-Rab6 has been the most difficult #cryoEM project I've worked on so far, but I'm so happy with how it came together and what we learned about Rab6 activation!

Fromme Lab@Fromme_Lab

We are excited to share a new preprint from the lab! Rab6 is a central regulator of the Golgi, important for trafficking and autophagy. @FeathersRyan used #cryoEM to determine the structural basis of the Rab6 activation process. (1/9)

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Fromme Lab@Fromme_Lab·8 May

@cryomariena Thank you, Mariena!!

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Dr Cryo Mariena@cryomariena·8 May

Dreamy!!! So very proud of you all 😍🍾

Fromme Lab@Fromme_Lab

We are excited to share a new preprint from the lab! Rab6 is a central regulator of the Golgi, important for trafficking and autophagy. @FeathersRyan used #cryoEM to determine the structural basis of the Rab6 activation process. (1/9)

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Fromme Lab@Fromme_Lab·8 May

@therickybaker @FeathersRyan Thank you, Rick!!

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Rick Baker@therickybaker·8 May

As always, awesome stuff from the @Fromme_Lab courtesy of @FeathersRyan ! Love to see cool structures of the membrane trafficking machinery!

Fromme Lab@Fromme_Lab

We are excited to share a new preprint from the lab! Rab6 is a central regulator of the Golgi, important for trafficking and autophagy. @FeathersRyan used #cryoEM to determine the structural basis of the Rab6 activation process. (1/9)

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Fromme Lab@Fromme_Lab·8 May

@peiferlabunc Thank you, Mark!!

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Fromme Lab@Fromme_Lab·8 May

Fittingly, the URL for the new AlphaFold3 server is: GOLGI.sandbox.google.com #GolgiTime *apparently it also works for proteins that do not localize to the Golgi, although we don't know why anyone would use it that way

Demis Hassabis@demishassabis

Thrilled to announce AlphaFold 3 which can predict the structures and interactions of nearly all of life’s molecules with state-of-the-art accuracy including proteins, DNA and RNA. Biology is a complex dynamical system so modeling interactions is crucial blog.google/technology/ai/…

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Fromme Lab@Fromme_Lab·7 May

@brettcollins100 @FeathersRyan Thanks very much, Brett!!!

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Brett Collins@brettcollins100·7 May

Lovely work from the Fromme lab. @Fromme_Lab @FeathersRyan

bioRxiv Cell Biology@biorxiv_cellbio

Structural basis for Rab6 activation by the Ric1-Rgp1 complex biorxiv.org/cgi/content/sh… #biorxiv_cellbio

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Fromme Lab@Fromme_Lab·7 May

@ryan_vignogna provided important contributions after @FeathersRyan started his postdoc training with @ZhongingAlong and @HughsonLab. We are grateful for help from @cryomariena and @ktspoth with #cryoEM data collection. #GolgiTime (9/9) bioRxiv: tinyurl.com/mrk2wk72

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Fromme Lab@Fromme_Lab·7 May

Taken together, our findings allow us to model the orientation of Ric1-Rgp1 on the Golgi membrane and understand how it activates Rab6. (8/9)

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Fromme Lab@Fromme_Lab·7 May

We are excited to share a new preprint from the lab! Rab6 is a central regulator of the Golgi, important for trafficking and autophagy. @FeathersRyan used #cryoEM to determine the structural basis of the Rab6 activation process. (1/9)

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