Georgia Critical Care Pharmacy Residency Symposium

Tenecteplase offers a simplified, single bolus alternative to alteplase for acute ischemic stroke comparable or superior efficacy in both LVO and nonLVO patients and may ⬇️ door to needle time and symptomaric ICH risk

Due to succinylcholine's shorter onset and duration of action, it may have a preferred PK profile compared to rocuronium.

Succinycholine has been found to have preferred intubation conditions compared to rocuronium. However, recent studies have shown no difference when comparing the two agents. 🤔

Would you use sugammadex in your emergency department?

Today's GCCPRS speaker is Dr. Aubrey Baker, a PGY2 Emergency Medicine resident at Grady Memorial Hospital!

Which anticoagulation reversal agent do you most commonly use/recommend at your institution for factor Xa-associated major bleeding?

Dr. Andrew Norton, PGY2 EM resident at Wellstar Kennestone, presenting about andexanet alfa vs 4F-PCC at the @GCCPRS today!

DYK 🤔: The 2024 guideline from the European Journal of Anesthesiology recommends PCCs or Andexanet alfa equally for anticoagulation reversal in patients taking direct oral anticoagulants with life threatening bleeding.🩸

What does your institution do to ensure that IV nitroglycerin is used safely for this purpose?

Dr. Ethan Young, PGY2 CC pharmacy resident at Piedmont Columbus Regional Midtown, leading our GCCPRS discussion today about heart lung interactions in emergency situations! 🫀🫁

🤔 Did you know? High intensity IV nitroglycerin infusion for SCAPE uses a different dosing range than when nitroglycerin is used for other indications. 📈

In which scenario would you be comfortable administering vasopressors peripherally?

Clinical pearl: 2021 Surviving Sepsis Guidelines recommend initiating vasopressors peripherally to restore MAP rather than waiting for central access to be secured. The safety of peripheral vasopressors was confirmed with an observational study by Yerke, et al in 2023.

⭐Excited for another excellent presentation today by Alexandria Howell, PGY2 Critical Care Resident at Grady! ⭐

What role does alkalinization of urine play in the management of salicylate toxicity?

Tx focuses on ion “trapping” in urine with sodium bicarb to ⬆️ elimination.

💊 Salicylate toxicity is characterized by metabolic acidosis driven by disruptions in cellular respiration. The weak acid kinetics of salicylic acid perpetuates the cycle of uncharged molecules crossing cell membranes.

Dr. Kelly Bodine, PGY2 EM pharmacy resident at Grady Memorial Hospital, in Atlanta presenting at the Georgia Critical Care Pharmacy Residency Symposium today on “Salicylate Toxicity”.

❓When using desmopressin to prevent overcorrection in hyponatremia, how likely are you to use it concurrently with hypertonic saline? 🧂

DYK 🤔: Desmopressin has promising evidence for use in prevention of overcorrection in hyponatremia, however the ideal strategy for use, proactive, reactive, or rescue, remains largely unanswered.