Herbert Lab

If you’ve ever wondered how cells tune positioning of organelles in response to cell shape change, please check out our new manuscript - mRNA trafficking controls cell-size-scaled organelle dynamics! nature.com/articles/s4146…

Our first post in 4-years! Very excited to share our work just published in @ScienceMagazine. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” – in angiogenesis and other tissues! science.org/doi/abs/10.112…

LAST CHANCE TO APPLY! If you love zebrafish, RNA, and imaging please apply for our Research Associate vacancy! Deadline for applications is 4th March. #zebrafish #RNA #postdoc jobs.manchester.ac.uk/displayjob.asp…

Do you love RNA? Optogenetics? Developmental Biology? Then we have the perfect job for you!! 4 years Research Associate postion - apply here: jobs.manchester.ac.uk/displayjob.asp…

Despite the national lockdown the 3rd North of England Developmental Biology (virtual) Symposium is still going forward on the 15th of January! Registration is free and everyone is welcome! Join us at: bit.ly/39WfbWq

In the latest preprint a phase-dependent relationship between Hes1 and cell-cycle is shown to underlie #cellcycle length heterogeneity in ER+ #breastcancer cells. Congratulations to the authors @nitin_sabherwal @Andyrowntree @JochenKursawe @papalopulu biorxiv.org/content/10.110… 1/6

Perturbation of RNA targeting by genomic excision of localisation elements caused filopodia to depolarise in cultured endothelial cells and, importantly, caused mispatterning of blood vessels in vivo!

Hypothesising that these RNAs share a common localisation mechanism, we then used the MS2 system to identify a shared 3’UTR motif that directed localisation to sites of emerging filopodia.

Our first RNA localisation publication! Fantastic effort from Guilherme Costa (now group leader @QUBelfast), and @joshjbradbury and Nawseen Tarannum embopress.org/doi/full/10.15…

Excited to see that my first, first-author paper with @samgriffjon and @PapalopuluLab is now out! Do you work on dynamically expressed proteins? Probably. Check to see if your favourite transcriptional regulator features in our results. nature.com/articles/s4159…

WE’RE HIRING! Are you a cell or developmental biologist? Are you interested in how cells coordinate multiple processes during tissue morphogenesis? Join our team! We’re looking for TWO new research associates! nature.com/naturecareers/… #sciencejobs #postdoc @jobRxiv @the_Node

Our first lock-down lab meeting!

18. 2xPostdoc positions: subcellular mRNA targeting, cell shape and tissue morphogenesis in zebrafish With @HerbertLab @OfficialUoM 🇬🇧 thenode.biologists.com/postdoctoral-r… thenode.biologists.com/postdoctoral-r…

miR-9 mediated noise optimization of the her6 oscillator is needed for cell state progression in the Zebrafish hindbrain biorxiv.org/content/10.110…

Shane has just given a great talk at #CBDB19 about exciting recent work on mRNA localisation in our lab!

Our super PhD student @sabrinaghd is here giving a great talk about her work at #CBDB19

With just 1 day to go, our last featured speaker is Sabrina Ghadaouia @sabrinaghd from the @HerbertLab in Manchester! She studies how endothelial cells integrate cell division with collective cell migration during zebrafish angiogenesis. @Official_BSCB @BSocietyDevBiol #CBDB19

Hello Twitter! #ourfirstTweet