The Intern At Work

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Nephro Trial Files #ThrowbackThursday 🧪 Bardoxolone ↑ eGFR (but safety concerns) 💧 Ultrafiltration worse than diuretics in cardiorenal HF 🧬 Rituximab ≈ cyclophosphamide in ANCA vasculitis nephrotrialfiles.substack.com/p/nephro-trial… #Nephrology #CKD #HF #Vasculitis #EBM

🫀New Cardio Trial Files! 💊Ticagrelor ≠ noninferior to prasugrel in DM + multivessel CAD ⚡Rivaroxaban ≈ aspirin post-AF ablation (↑ bleeding) 💉Evolocumab ↓ first CV events (primary prevention) 🧠cardiotrialfiles.substack.com/p/cardio-trial… #CardioTwitter #PCI #AFib #EBM

🧠 IBD Trial Files Throwback 🦠 FMT in UC → remission linked to specific bacteria/metabolites 🧬 Infliximab trial (1997) → launched the biologic era in Crohn’s 📖 ibdtrialfiles.substack.com/p/ibd-trial-fi… #IBD #Crohns #UlcerativeColitis #FMT #Infliximab #MedTwitter

🧬AllergyImm Trial Files Throwback 🥼Dupilumab → ~60% histologic remission in EoE 🥜Omalizumab → ↑ food allergy reaction thresholds 👃Dupilumab → ↓ nasal polyp burden Biologics transforming allergic disease care. allergyimmtrialfiles.substack.com/p/allergy-and-… #Allergy #Immunology #Biologics

🧪 New Trial Files! 🧬 Mifepristone in T2DM + hypercortisolism → HbA1c ↓ 💉 Evolocumab → ↓ first CV events (no prior MI/stroke) 👁️ Tenecteplase in CRAO → no vision benefit 🧠 trialfiles.substack.com/p/trial-files-… #EBM #CardioTwitter #EndoTwitter #MedTwitter

🧪Critical Care Trial Files Throwback ICU fluids: 💧Colloids vs crystalloids → no mortality diff 🩸Albumin vs saline → equivalent outcomes ⚖️Balanced vs saline → no AKI benefit 🧠 criticalcaretrialfiles.substack.com/p/critical-car… #ICU #FluidResuscitation #CriticalCare

🩸Thrombo Trial Files #ThrowbackThursday TXA across settings: 🩺Noncardiac surgery → ↓ bleeding 🧑‍⚕️Liver resection → no benefit, ↑ complications 🚑TBI → no neurologic benefit Procedure-specific TXA effects thrombotrialfiles.substack.com/p/thrombo-tria… #TranexamicAcid #Surgery #TBI #Thrombosis

🩸New Heme Onc Trial Files! 🎯Epcoritamab-R² → 95% ORR & ↑PFS in R/R FL 🧬Venetoclax-dex signal in t(11;14) myeloma 🧪CAR-T: 61% relapse-free at 5 yrs (LBCL) Bispecifics + precision therapy + durable CAR-T. 🧠hemeonctrialfiles.substack.com/p/heme-onc-tri… #Lymphoma #MultipleMyeloma #CART #HemeOnc

📬 Stay in the Loop with Medicine Pods! Sign up for our monthly newsletter at medicinepods.com to get the latest podcast episodes and medical infographics, delivered straight to your inbox! #MedEd #MedTwitter

🚨Diabetes Trial Files #ThrowbackThursday ⚖️Tirzepatide→~21% weight loss 💉Tirzepatide > semaglutide for A1c & weight 🫀Dapagliflozin ↓HF events (±diabetes) Trials that changed cardiometabolic care 🧠diabetestrialfiles.substack.com/p/diabetes-tri… #EndoTwitter #CardioTwitter #Obesity #SGLT2 #GLP1

🚨 Cardio Trial Files #ThrowbackThursday 💉 Darbepoetin fails in HFrEF anemia 🫀 TAVR = noninferior to surgery in low-risk ⚡ DDDR pacing worse than VVI in ICD patients Old trials, lasting impact 🧠 cardiotrialfiles.substack.com/p/cardio-trial… #CardioTwitter #TAVR #ICD #HFrEF #EBM

🧪 New Trial Files! 🥗 MD for IBS: Superior to traditional diet (62% vs 42% response) 💉 EVERDAC: Noninvasive BP = art line for ICU mortality ❤️ REBOOT-CNIC: BBs didn’t help MI pts with preserved EF 🧵 trialfiles.substack.com/p/trial-files-… #IBS #ICU #CardioTwitter #MedTwitter #EBM

🧠💪 New Critical Care Trial Files 🏋️ RT boosts ICU recovery 💉 Noninvasive BP ≈ art line in shock (EVERDAC) 🤖 Closed-loop vent = protocolized vent for VFDs (INTELLiVENT) 📎 criticalcaretrialfiles.substack.com/p/critical-car… #ICU #Ventilation #Physio #EvidenceBasedMedicine

📊 New @RoundsTable infographic! 🦵Metformin for knee OA in overweight/obesity (JAMA 2025) ➡️ Greater pain reduction at 6 months vs placebo (Δ −11.4 mm VAS; 95% CI −20.1 to −2.6) #MedTwitter #FOAMed #Rheumatology #Osteoarthritis #ClinicalTrials

Heme Onc Throwback Thursday! 📌 A+AVD: ↑ 2yr PFS vs ABVD (82.1% vs 77.2%) 📌 PET-guided eBEACOPP: de-escalation safe if PET-2 neg (~92% PFS) 📌 Nivo+AVD: ↑ 2yr PFS (92% vs 83%) + better safety vs BV+AVD 🧵hemeonctrialfiles.substack.com/p/heme-onc-tri… #HemeOnc #HodgkinsLymphoma #AVD #Immunotherapy

🎙️ @RoundsTable Listeners, This week Dr. @FralickMike breaks down a new RCT on metformin for knee osteoarthritis in patients with overweight/obesity Can it reduce pain & improve function? #MedTwitter #FOAMed #MedEd #Rheumatology #Osteoarthritis #Metformin #ClinicalTrials

📬 Stay in the Loop with Medicine Pods! Sign up for our monthly newsletter at medicinepods.com to get the latest podcast episodes and medical infographics, delivered straight to your inbox! #MedEd #MedTwitter

🩸 Hemolysis made simple. Intrinsic vs extrinsic, DAT+ vs DAT−, immune vs non-immune — all on one high-yield page you’ll actually remember. 📌 Save this for wards & exams: fralicklab.com/book #MedPods #HemeTwitter

📊 Learn test characteristics (sensitivity, specificity, PPV, NPV) in just 6 minutes. Perfect for quick review before exams or clinical rounds! 🧠👇 ▶️ Watch now: youtu.be/cSvWSat3vVg #MedicalEducation #MedTwitter #FOAMed #Diagnostics #MedStudent

🧪 New Nephro Trial Files •Pegcetacoplan ↓ proteinuria by 67% in C3G/IC-MPGN •AKI after surgery ↓ from 22.3% → 14.4% with preventive care •Oral semaglutide slowed eGFR decline but no major renal outcome win 🔗 nephrotrialfiles.substack.com/p/nephro-trial… #CKD #AKI #Glomerulonephritis #T2DM