John McCormack

#Evolution is this: 🐜🦎🐒🙍🏻‍♀️ (today) | | |__| | |___💀 (ancestor) |_____| ↑ | Time Not this: Time → 🐜→🦎→🐒→🙍🏻‍♀️ #phylomoji

A paper in Nature describes a collection of soft‑bodied fossils discovered in a quarry in China, dating to around 512 million years ago. The Huayuan biota contains 153 animal species from 16 major groups, of which 59% are previously undiscovered species. go.nature.com/49KUOdw

Overall, we show that population size has a big influence on the evolution of structural variants. There is so much to be uncovered with long-read sequencing: We found 3 million indels and 450,000 structural variants that otherwise would have remained as "DNA dark matter"!

(2) in the large-population, continental Woodhouse's Scrub-Jay (interior US), copy number variants seemed to be adaptive, contributing to gene expression, despite finding the largest selfish repetitive unit ever found in birds (18,000 bp repeats) on the Z chromosome!

Happy to share our new paper out in @ScienceMagazine on the evolution of structural variation in a closely-related bird species complex, led out of Scott Edwards lab science.org/doi/epdf/10.11…

I've been reading @matthewcobb's new biography on Francis Crick. It contains many surprises, especially regarding the solving of DNA's structure. I finished reading through 1953. Here my notes so far: 1. Photograph 51 was not taken by Rosalind Franklin. It was taken by Raymond Gosling, a PhD student working with Franklin, in May 1952. 2. Also, Photograph 51 played no role in Watson/Crick's model. Writhes Cobb: "Crick did not see the photo until weeks after they had discovered the structure, nor did it provide Watson with any new information beyond a very rough idea of the itensity distribution [of the x-ray crystallography data.]" Franklin's real contribution to the structure, and an idea which she discussed as early as 1951, was instead that the crystalline form of DNA was "a face-centred monoclinic unit cell with the C-axis parallel to the fibre axis." In other words, her crystallography data showed that there were two strands in DNA, and that those strands ran antiparallel with the bases inside. Again, she publicly disclosed this in a 1951 lecture, but apparently all Watson could recall about that lecture was Franklin's appearance, as he later described in his book. 3. It's widely thought that Watson and Crick, after building their model, walked into the Eagle pub in Cambridge and told "everyone within hearing distance that [they] had found the secret of life." This came from Watson's book, The Double Helix, but it is entirely made up. Crick said it did not happen, and Watson admitted the same in 2016. 4. Around the same time that Max Perutz was trying to solve a protein structure for the first time, a researcher in New York named David Harker received a $1 million grant to try to become the first instead. This is surprising for two reasons: a) I had never heard of Harker and b) $1 million was a HUGE sum at the time; a typical house in England cost ~$1,800 at the time. TL;DR The best-funded labs do not always get the spoils. 5. Between 1947 and 1949, "nearly two hundred papers were published on DNA." This at a time when papers were much less frequent than they are now. This was surprising because the structure, let alone proof that DNA was the genetic material, did not come until many years later! The lesson, of course, is that just because a field seems "hot" does not mean you should not work on it; the big discovery may still be there for the taking. 6. Freeman Dyson warned Crick against migrating from physics into biology. "If you switch to biology now, you will be too old to do the exciting stuff when biology finally takes off," Dyson told him. 7. Watson and Crick (and many other molecular biologists who came from physics) explicitly said they decided to pivot into biology after reading Schrodinger's small book, "What is Life?" In short, writing can have a huge influence on the trajectory or invention of scientific fields. I recommend reading this book. My short social media posts cannot do the story justice.

I'm a single issue voter, I want the warm lights back. Streetlights are too blue. Headlights are too bright. It's a crime against nature and God. We need to demand 2800K or below color balance for all outdoor lights. Some cities regulate 3000k max, that's still too damn blue.

all fish team vs. all bird team had to leave a lot of guys off the roster. jalen beeks, ralph garr, etc.

We can, however, say that some of these fashion decisions are questionable

📣📣📣PhD position available in my lab at @mncn_csic in Madrid to study speciation mechanisms in oceanic island birds, using phenotypic and genomic data. - 💰4-year contract - 🎓Biol, Genetics, Master's, English. - 📅Apply by October 15 -👉CV & letter to b.mila@csic.es

The conversion of college campuses into the least socially and intellectually free places in the country is complete. You'll get more diversity of thought at a rural Wyoming bar, and I'm absolutely serious. I don't like going to campuses anymore.

Sometimes it's nice to remember that even Marcus Aurelius was like "you don't have to comment on everything bro"

“These past extinctions are kind of weird, and we don't think they're a road map to future extinctions.” sciencenews.org/article/sixth-…

The book Doctors by Nature "invites deeper reflection on what it means to medicate, how landscapes shape access to medicine, and whether we humans are as discerning in our self-medicating choices as our nonhuman counterparts." Read the #ScienceBooks Review on #ReadABookDay: scim.ag/3FQfvbk

At least 25 species of parrots have become naturalized in the US, which are just a fraction of the 1,500+ kinds of wild birds that Americans imported as pets. We've mostly forgotten about the wild bird trade, but the 1950s-80s was an unprecedented shuffling of biodiversity.

A Genomic Perspective on Species Delimitation | happy to share results of this collaboration with an awesome team! #cienciacriolla annualreviews.org/content/journa…

Job ad here 👉 jobs.chronicle.com/job/37844863/r…

New position in the Biology dept at @Occidental College! Resident Assistant Prof. of Imaging & Data Analysis. Combines teaching with directorship of our new imaging center. Great opportunities for research w/ excellent undergrads doing high-level research. Job ad below