Schübeler Lab

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Schübeler Lab

Schübeler Lab

@SchubelerLab

Studying gene regulation in chromatin @FMIscience

Basel, CH Bergabung Şubat 2019
383 Mengikuti4.7K Pengikut
Schübeler Lab
Schübeler Lab@SchubelerLab·
Using this definition leads to the observed continuum of chromatin sensitivities across TFs. Thanks to all authors and for the input from lab members and members of the computational biology platform. Looking forward to feedback. Here or preferred at @schubelerlab.bsky.social
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Schübeler Lab
Schübeler Lab@SchubelerLab·
The framework quantifies chromatin sensitivity as the degree to which binding is determined by the motif sequence, i.e. the motif affinity, versus the flanking sequence around the motif, likely indicating the presence of additional motifs bound by other TFs.
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Schübeler Lab
Schübeler Lab@SchubelerLab·
Excited to share our latest preprint. biorxiv.org/content/10.110…. Lead by Lukas, we investigated multiple ways of assessing a TF's sensitivity to chromatin based on genome-wide binding profiles. The developed methods allowed us to quantify chromatin sensitivity across tested TFs.
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Schübeler Lab
Schübeler Lab@SchubelerLab·
Demonstrates how a combination of opportunistic binding and context-specific chromatin-opening underpin TF specificity, driving differentiation trajectories.
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Schübeler Lab
Schübeler Lab@SchubelerLab·
Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. sciencedirect.com/science/articl….
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Schübeler Lab@SchubelerLab

Excited to share our latest preprint. Lead by Sevi (@biosevi) we asked how transcription factors (TFs) with short and abundant motifs drive specific cell fates. Our test cases: Two bHLH factors that bind to seemingly similar E-boxes. 1/7 biorxiv.org/content/10.110…

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Sevi Durdu
Sevi Durdu@biosevi·
🧬Preprint alert! FGF3 isn’t just a paracrine signal, it’s a self-editing morphogen. Fgf3-producing cells ignore parts of their own signal via nuclear repression of select target genes. A built-in asymmetry between senders and receivers! #FGF #Morphogen biorxiv.org/content/10.110…
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Schübeler Lab
Schübeler Lab@SchubelerLab·
Including time for a hike in the beautiful surrounding (with limited visibility on that day fitting the topic) and, according to some, too many quotes from Goethe’s Faust😀
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Schübeler Lab
Schübeler Lab@SchubelerLab·
Engaged and stimulating discussions on lab strategy and how to further embrace, teach and implement machine learning to gain mechanistic insights into gene regulation.
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Schübeler Lab
Schübeler Lab@SchubelerLab·
Recent lab retreat in beautiful Staufen im Breisgau in the Hotel “Der Löwen”, third oldest inn in Germany (1407) and famous for being the birthplace of the Faust legend.
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