Tsung-Han Chou

Nature research paper: Molecular mechanism of ligand gating and opening of NMDA receptor go.nature.com/3AeGQRD

New images from Prof @furuttini lab reveal the 3D structures of the GluN1a-2C NMDA receptor in exquisite detail. Better understanding this receptor may empower drug developers to come up with new treatments for numerous psychiatric disorders. cshl.edu/a-new-look-at-…

Our manuscript on understudied GluN2C- and 2D-containing NMDAR is published online today. This project was one of many ‘homework’ given to us by #John_Lisman, who suggested GluN2C hypofunction be involved in schizophrenia. 1/4) authors.elsevier.com/a/1f%7Ew43vVUP…

Our lab’s latest paper published today in @eLife in collaboration with @Lab_FURUKAWA @TsungHan_Chou shows that D-serine competes with glutamate for binding to the GluN2A NMDAR subunit. elifesciences.org/articles/77645

Our latest paper on therapeutic channel blockers against NMDA receptors is published online. We measured the on and off speeds of the selected channel blockers by electrophysiology. The slower the off speeds the more severe psychotic side effects nature.com/articles/s4159… 1)

Nature research paper: OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage go.nature.com/3PqqCrO

New preprint from the Lau Lab and @Lab_FURUKAWA. We used molecular dynamics simulations and electrophysiology (@TsungHan_Chou) to study the role of D-serine binding to NMDAR LBDs.

Run AlphaFold structure prediction from ChimeraX. youtu.be/le7NatFo8vI

Thanks all for your kind words on our work. We are happy we finally got to publish this extensive study by @TsungHan_Chou @nami_tajima and @opuntiavisual. We dedicate this manuscript to the memory of our friend, Jim Howe, who made enormous contributions to the iGluR field.