Caleb Appleton

@JonMSchwartz Agreed, obvious in hindsight. Jim Fan called it the integral of data types at Actuate and I thought that was a good way to frame it

People in the robotics industry like to argue about what type of data collection will get us to generally capable robots. It’s starting to look like the answer is all of it—teleop, direct capture (UMI), human data, and sim. In hindsight, feels a bit obvious?

@benscharfstein I think it also probably tells you something about comp and comp structures at Anthropic and TML.

~no one waving anthropic or thinking machines to join meta really shows the value of hiring missionaries over mercenaries. It’s hard to fake a missionary culture. The founders need to live the mission in the tradeoffs they make even when it’s inconvenient for the business

@srikosuri @StJude Incredible news. So happy for you both

Good news. After 2 rounds of venetoclax, GO, + chemo, my daughter has had a complete response. No detectable signs of the tumor that had completely shut her eye, which she was dangerously close to losing. 🙏🏾 to the amazing team @StJude & the community for helping us get here.

🥁 October Featured Investor: @appleton_caleb, @BisonVentures Caleb’s led investments in techbio & AI (@Vivodyne, @Cobot) and shares how a key career moment shaped his VC approach: evca.org/blog/caleb-app…

@eladgil Row34 for seafood and a great drink list

Dropped by Georgia Tech to remind the Yellow Jackets to register to vote! iwillvote.com

@IanRountree Well, have you eaten?

Going through cold DMs... - "I am looking to put a train on the moon." - "I'm building a digital cloaking device." - "I'm solo GP,Currently building my vc fund. need your feedback on my thesis." - "...working on a company to build that will 3d print boats." - "Have you eaten?"

@PatrickMoorhead @AMD @LisaSu What do you think of the margin profile of ZT and the impact that has on AMD? Surprising to see this acq. at half of reported revenue suggesting a less than rosy GM.

AMD Boosts GPU Server Design Capabilities With ZT Systems Acquisition Today, AMD announced it is acquiring ZT Systems, a leading hyperscale systems design and ODM house for GPU rack systems. I want to thank @AMD CEO @LisaSu for her time yesterday to break the deal down for me. Analysis in the link below. $AMD

@adityaag I've been on a similar cadence (200 miles, 16 hours of ride time). For me the biggest value is the in car experience (music, AC) coupled with the smoothness of accel/deceleration; it means I can work on a laptop or take a call without fear of car sickness for first time in years

I have been using Waymo every day for 2 weeks now and before that used Uber ~every day for 10+ years. Some thoughts on this transition and on my own behavioral changes:

@Sergiu_P_Pasca @Nature Congrats @Sergiu_P_Pasca !

Today, I’m thrilled have our lab’s work featured on the cover of @Nature In this article, we have developed a therapeutic approach for a severe condition called Timothy syndrome. This has been a long journey. It started with making hiPS cell-derived neurons in 2D cultures 15 years ago when I was a postdoc and continued with later creating in the lab #organoid and then #assembloid models of this disease caused by a mutation in a calcium channel. Over time, these human cellular models and the biological insights we gained enable us to design a therapeutic strategy, which we validated in vivo following circuit integration of patient-derived organoids into the rat brain. Grateful for the incredible work led by @XiaoyuChenxy and @fikribirey in the lab! And the many close collaborators who participated to this line of research over the years.

@neildevani We are!

Another week and another new "climate tech" fund that only wants to invest in SaaS. Who are the early-stage climate tech investors explicitly *not* focusing on SaaS?

@McStempel ugh.

A misstep I see a few times per year by VCs or their EAs: presuming that my cc’ed cofounder is my assistant We just had our first 2024 instance of this, and this would never happen if the cc’ed individual was named Justin rather than Julianna

@sfstandard If only it was to Billy Bishop it would be a true home run

Porter Airlines will begin offering daily nonstop flights between San Francisco International Airport and Toronto Airport with free booze. sfstandard.com/2023/10/03/por…

@LukeBornheimer I didn’t know Hansel but reading this brought tears to my eyes. Hansel seems to have embodied the ‘why I ride bikes’ that exists in all of us. The world needs more Hansels.

San Francisco has lost a warm, kind, and joyful person 💔 Hansel Palarca-Reiva was beautiful — inside and out — and his larger-than-life smile was infectious, especially while he rode his bike along Car-Free JFK Promenade and Great Highway Park ❤️ Hansel will forever be missed.

@OpenJonathan They odds remain highly varied across a couple different wager sites. Good opportunity for someone to make a ton of money if they have conviction. Me, on the other hand, I’m just enjoying the internet drama and the possibility of something groundbreaking

If we wish it so, maybe it'll make it so. manifold.markets/QuantumObserve…

In 2022, less than 2% of app downloads converted to paying subscribers But that's not how the top subscription apps perform We found out what success looks like and published our findings in our State of Subscription Apps report These are the highlights 🧵

These notes nicely compliment our previous efforts such as: ML Notebooks: github.com/dair-ai/ML-Not… ML Notes: github.com/dair-ai/ML-Cou…

@McStempel Yes without a doubt.

Are the unhinged tangents on cooking recipes mostly for search engine optimization?

Somehow it’s Election Day and democracy is in peril, yet all people on the bird app care about is a middling crypto exchange that sponsored some NBA teams

@glagoudas @RiceUniversity Congrats Georgia - really impactful work!

Watching Biden’s speech right now for the Cancer Moonshot and launching a Biotech Executive Order. What an intersection of my life - JFK’s speech 60 yrs ago was at my alma mater @RiceUniversity, the speech is taking place at my home for 7yrs Boston, and I helped write this E.O.