CPPopt

We did it! First CPPopt feasibility and safety trial! Results are here doi: 10.1089/neu.2021.0197 Is precision medicine in #TBI in #CriticalCare feasible? CPPopt as an individualised dynamic CPP target for protecting the brain. Thanks #COGiTATE team for this work!

The President’s Commendation for a sustained contribution to the College was presented to Dr Rana Hafiz Ur Rehman. Dr Ari Ercole gave the Macintosh Professor Lecture. Seen here with President Dr Claire Shannon and Prof Iain Moppett. Read more: ow.ly/NsKo50UeHFx

Wonderful news for a remarkable colleague, friend, and doctor.

Traumatic brain injury #TBI phenotypes from @CenterTBI #ICU data by probabilistic time-series clustering 𝗧𝗲𝗺𝗽𝗼𝗿𝗮𝗹 𝘃𝗮𝗿𝗶𝗮𝘁𝗶𝗼𝗻 of brain injury 𝗯𝗶𝗼𝗺𝗮𝗿𝗸𝗲𝗿𝘀 = missing link in describing the 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 course authors.elsevier.com/c/1i5LY5FFzKyQ… @TheLancetNeuro

ICP is strongly confounded by therapeutic intensity level (TIL) after #TBI. Measuring TIL crucial to understand severity Various TIL scores validated in @CenterTBI doi.org/10.1089/neu.20… @TBI_data_guy nails TIL representing 'refractory' ICP: TILᵐᵉᵈ≥7.5

A solution to the age-old problem of where to zero the transducer in neurocritical care... rdcu.be/dlTOs doi.org/10.1007/s12028…

Does what happens in #ICU stay in ICU after #TBI? Well done @TBI_data_guy for time-series #machinelearning model ingesting 𝑎𝑙𝑙 @CenterTBI data with minimal pre-processing looking at contribution of clinical course events to outcome in @npjDigitalMed nature.com/articles/s4174…

Precision medicine to improve outcome after traumatic brain injury: data-driven approaches to identify pathophysiological or pathobiological mechanisms to individualize treatments 🧠suggestions for #TBI phenotypes 🧠methodological considerations #FOAMcc 🔓 rdcu.be/dhtsr

Machine learning and novel algorithmic techniques show great potential, but need to be applied and interpreted correctly Right question+right data+right method doi.org/10.1038/s41591… @CC4AIM

Unsupervised clustering in @CenterTBI finds 6 stable endotypes of #TBI in the #ICU ⚠️Systemic metabolic stress important differentiating patients as well as traditional GCS classification doi.org/10.1186/s13054… rdcu.be/cSxc0

#TraumaticBrainInjury research often dichotomises outcomes. Here's how to handle ordinal outcomes from @shubhayu_neuro including a #machinelearning approach using 𝙖𝙡𝙡 the @CenterTBI features for best prediction doi.org/10.1371/journa…

Some 𝘷𝘦𝘳𝘺 important things to know about the challenges of large-scale observational data collection in #TBI from @CenterTBI doi.org/10.1007/s12028…

Primary analysis of @global_neuro Global Neurotrauma Outcomes Study #GNOS published tonight @TheLancetNeuro. thelancet.com/journals/laneu… Phenomenal collaboration of clinicians from 57 countries 🌍. #WFNS2022 #globalneurosurgery #globalneurotrauma #TBI

Yes, and Cogitate study is one of the most read papers in 2021!!

COGiTATE results presented at the #BNRG2021 by our team member @erta_beqiri Great meeting, fantastic talks! Inspiration for the future @BrainPhysics @icm_plus

Reduced physiological cross-talk associated with mortality after #TBI Well done Giovanna, @BrainPhysics @DrSmielewski @erta_beqiri @pl219_Cambridge @AriErcole and all @CenterTBI collaborators doi.org/10.1007/s12028…

First ever prospective randomised controlled trial to assess feasibility and safety of a 'digital biomarker' for individualised care of #TBI patients on #ICU ➡️ both feasible and safe #COGITATE doi.org/10.1089/neu.20…

We did it! First CPPopt feasibility and safety trial! Results are here doi: 10.1089/neu.2021.0197 Is precision medicine in #TBI in #CriticalCare feasible? CPPopt as an individualised dynamic CPP target for protecting the brain. Thanks #COGiTATE team for this work!

Glasgow Coma Score & pupil reactivity=crucial #TBI outcome determinants but timepoints frequently missing in real-world data Evaluation of methods for effective imputation by @CenterTBI... ... the answer depends on the question! doi.org/10.1371/journa…