👋Channelomics.bsky.social👋

FYI information, the @Channelomics .bsky.social Ion Channel feed is now flowing, this means if you follow us on there, any post you make (on that platform) including #ionchannel will be added to the Ion Channel feed. bsky.app/profile/did:pl…

Mechanism of conductance control and neurosteroid binding in NMDA #IonChannel receptors | Nature Sorry it is paywalled…. But look at the beautiful channels 🥲ift.tt/paZx3q7 via Mastodon

Deletion of the TRPV1 #Ionchannels attenuates afferent renal nerve responses to renal artery occlusion but not elevated renal pelvic pressurehttps://physoc.onlinelibrary.wiley.com/doi/10.1113/JP289721?af=R via Mastodon

Substrate stiffness attenuates cardiomyocyte depolarization slope via sodium channel modulation (Increased stiffness of the substrate causes the dysfunction of Nav1.5 #Ionchannel kinetics) ift.tt/uwRWsPf via Mastodon

Sclareol and cinnarizine are non-selective inhibitors of voltage-gated Cav1.3 L-type Ca2+ #ionchannels Open access. ift.tt/ag4q7LE via Mastodon

Mouse retinal ganglion cells and night blindness | TRPM1 #ionchannels, mGluR6 of retinal ON bipolar cellsJ.General Physiol. ift.tt/wLsXrpg via Mastodon

Aberrant HCN4 #ionchannel expression: Impacts on neuronal excitability and implications for epilepsy pathogenesis - Spyrou - British Journal of Pharmacology Paywalled ift.tt/C58Hw1p via Mastodon

Piezo1 #ionchannels regulate the mechanotransduction of soft matrix viscoelasticity | Nature Communications nature.com/articles/s4146… via Mastodon

Massive reduction of RyR1 #Ionchannel in muscle spindles of mice carrying recessive Ryr1 mutations alters proprioception and causes scoliosis - Ruiz - The Journal of Physiologyhttps://physoc.onlinelibrary.wiley.com/doi/10.1113/JP287832?af=R via Mastodon

Augmenting AMPA #IonChannel signaling after spinal cord injury increases ependymal-derived neural stem/progenitor cell migration and promotes functional recovery - Nature Neuroscience ift.tt/e584vOo via Mastodon

Curious… what’s up?#IonChannelsExpression of Concern ift.tt/TcMmgzo via Mastodon

Voltage-gated sodium #IonChannels: Mechanisms, disease, and a growing research community *Special Issue* Journal of General Physiology. ift.tt/O0t43e2 via Mastodon

Fatigue arising from KATP SUR2 gain-of-function in Cantu syndrome mice Scala -> Nichols. £€$¥ift.tt/uqkQB7e: Cantu syndrome -> muscle fatigue via overactive KATP #Ionchannels. Reversed by glibenclamide, suggesting possible new treatment. via Mastodon

A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 #IonChannel receptor - Nature Communicationshttps://ift.tt/aFWedl1 via Mastodon

Delta-type glutamate receptors are ligand-gated #ionchannels |Nature £$¥€ift.tt/F2RYOcT via Mastodon

Distinctive GABA A #Ionchannel receptor subunit expression modulates cell specific EMT and functional responses in glioblastoma breast and ovarian cancer - Scientific Reports ift.tt/eEYGR2l via Mastodon

Calmodulin binding is required for calcium mediated TRPA1 #IonChannel desensitization | Nature Communications ift.tt/v6SAd2x via Mastodon

TLDR: CBD alone doesn’t stop drug-resistant epilepsy. But paired with GABAergic meds like phenobarbital or diazepam, it cuts mortality and resistance. But combining with sodium channel blockers may worsen seizures ift.tt/Zg2sOwj From @ChannelOmics.bsky.social #IonCha…

Don’t know why IFTTT screwed up the link 🥲 nature.com/articles/s4200…

A conserved mechanism of LRRC8 #ionchannel inhibition by two structurally distinct drugs | Communications Biology ift.tt/xQOK7PY access From @ChannelOmics.bsky.social #IonChannels

TRPM7 Deficiency Accelerates Vascular Senescence by Inhibiting H3K18 Lactylation - Wang - Aging Cell - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/ac… From @ChannelOmics.bsky.social #IonChannels