Tim Jen MD MHSc FRCPC

@RAPMOnline feature tweeted our study!! @ronmree @ChrisPrabhakar @sun_terri @SachMehta @StephanKSchwarz

The Spring issue of Anesthesia News is here 🌱 Explore #CASAM2026, Strategic Plan progress, education growth, and insights from the Anesthesia Delivery Taskforce shaping the future of care in Canada. 📖 online.fliphtml5.com/blqt/kjeq

Anthropic SCR designation is unfair, unwise, and an extreme overreaction. Anthropic is filled with brilliant hard-working well-intentioned people who truly care about Western civilization & democratic nations success in frontier AI. They are real patriots. Designating an organization which has contributed so much to pushing AI forward and with so much integrity does not serve the country or humanity well.

Check out the February issue of the BJA #miniflipbook, which showcases all of our #FREE articles on topics including: #stellateganglionblock #bonferroni #statistics #fluidbalance #dexmedetomidine #fentanyl #prostaglandins #regionalanaesthesia #PPCs bja136-2.elsevierdigitaledition.com

In a new article published in @_Anesthesiology, researchers investigate whether perioperative pain is associated with the development of myocardial ischemic events in patients undergoing hip fracture surgery. Learn more: ow.ly/iexn50Ykzpb #anesthesiology #anesthesia

New #RCT showing no #significantdifference in analgesia with the addition of #dexmedetomidine to #dexamethasone with a #supraclavicularbrachialplexus block bjanaesthesia.org/article/S0007-…

📊 JAMA Guide to Statistics and Methods: The win ratio is a statistical method for hierarchical composite outcomes, offering a patient-centered summary of treatment effects by prioritizing more important clinical events in clinical trials. ja.ma/3OvSkHQ

Our new editorial in @CJA_Journal: From h-index to hashtags: the modernization of research and publication metrics Introducing our concept of "social media biofeedback" for journals and authors @alopipatelmd @MaryannCTurner @Ropivacaine pubmed.ncbi.nlm.nih.gov/41712179/

Cardiologist wins 3rd place at Anthropic's hackathon. Out of 13,000 applications. Built in 7 days by Michał Nedoszytko MD. Coded day and night - in the hospital, in the cloud, while flying from Brussels to San Francisco. A few years ago, it would have been impossible for a doctor to build this alone in just a couple of days. AI changed that. The project is called postvisit.ai. It is an AI agentic care platform for patients. Including reverse AI scribe it is a companion that guides the patient from the moment they leave the doctor's office. Powered by the massive context window of Opus 4.6, it allows patients to explore their full medical history, connected devices, Evidence Based resources and external data sources — all in one place. Today, the barrier to entry has vanished; even a practicing physician can build an application from scratch.

Considering applying for CIHR funding? Use our new guidelines and example scenarios to help calculate whether you are an early career, mid-career, or senior researcher! cihr-irsc.gc.ca/e/54581.html?h…

Etomidate has long been favored for rapid sequence intubation, but concerns about adrenal suppression, especially in sepsis, have led many clinicians to choose ketamine instead. A new trial compares the two. Read the Key Results: jwat.ch/4theZHA

RCT: Among older adults with frailty scheduled for surgery, assignment to home-based prehabilitation before surgery did not improve postoperative disability scores or reduce complications. ja.ma/3M2tdvp

Dengue is DONE Singapore just released a study that might end mosquito-borne disease as we know it. No drugs. No vaccines. Just mosquitoes fighting mosquitoes. > infected male Aedes aegypti with Wolbachia bacteria > released them into the wild to mate with normal females > every single offspring from those matings was dead on arrival > wild mosquito population practically vanished in treated areas This isn’t some lab experiment btw. 24 month randomized trial. 15 geographic clusters. Nearly 400,000 residents. Published in the New England Journal of Medicine. The results are insane: > mosquito abundance in treated areas dropped from 0.18 to 0.041 > control areas went the other direction to 0.277 > 6% dengue positivity in treated zones vs 21% in control zones > protective efficacy of 72% No drug. No vaccine. No chemical spray. Just evolutionary biology weaponized against the most dangerous mosquito species on earth. For context we’ve been fighting Aedes aegypti the same way for decades. Fogging. Larviciding. Nets. Awareness campaigns. And dengue kept spreading. More cities. More countries. More deaths. 400 million infections a year. The problem was never effort. We were trying to kill mosquitoes after they already existed. Singapore said what if we just make sure they’re never born. Cytoplasmic incompatibility. That’s the mechanism. Wolbachia infected males mate with wild type females and the eggs never develop. Do it at scale and the entire population collapses from the inside. Generation after generation. They didn’t fight the mosquito. They turned reproduction into a weapon against it. No pharmaceutical intervention for dengue has ever come close to 72% efficacy at this scale in a real world setting. And this is just Singapore. Imagine this deployed across Southeast Asia. South Asia. Sub Saharan Africa. Latin America If you’re still thinking about dengue control as fogging trucks and awareness posters you’re looking at the wrong decade. This is the most important vector control breakthrough in years and nothing else we have even competes.

Again the line “ gastric ultrasound may guide clinical decision making”….. but I still think we really don’t know “how” It’s tricky…. We know the incidence of a non-empty stomach in all elective patients is around 5-6% (much higher in some series) But the incidence of aspiration is around 1 in 10,000 That’s 600-fold lower If we start doing RSIs or even intubating all these patients then there is a significant risk we’ll cause more harm. So I think identifying who has a full stomach is the easy bit. Working out who is actually at high risk or deciding what to do about it is the complex one!

This is so important to read and internalize for proceduralists, and really anyone who takes care of patients One pearl of many: “Experience can actually reduce accuracy if it teaches the wrong lesson”

🎙️ CACB Beyond the OR: Rethinking Outpatient TKA 💉 Alopi Patel, MD, with Josh Gleicher, MD, MSc, FRCPC & Hermann dos Santos Fernandes, MD, PhD, discuss outpatient continuous adductor canal block for TKA 🦻🏼 rapmfocusbmj.podbean.com/e/episo

People who embrace AI will survive, and people who shun AI will be replaced. I have no doubt.

I don't actually think people know about Claude Cowork and what it means. I screened 33000 titles/abstracts in 1 day for my upcoming presentation, highlighting the studies that should be reviewed. It's GOOD. I prepared a presentation for a meeting in less than 10 minutes. Wild

Don't miss editorial "Multimodal Analgesia in Enhanced Recovery After Cardiac Surgery—Does it Work?" from Drs. Abimbola Faloye & Stephanie Ibekwe buff.ly/SpSNe7j ✅️ Add anesthesia-related variables to clinical databases ✅️ Develop well-designed prospective studies

🩺 Reassessing QTc Risk in Perioperative Methadone 📖 In a new study, intraoperative methadone was not associated with increased QTc prolongation during major surgery, with similar QTc risk vs non-methadone patients. 🔗 doi.org/10.1136/rapm-2… #RAPM #Anesthesia #PainMedicine

Next week! Join Drs. Leena Mathew and Amy Shultz Pearson for a free webinar where they will discuss Aromatherapy for Pain and Anxiety. February 10 @ 4:00 pm ET. Learn more & register👇 ow.ly/axXN50Y4yjO #PainMedicine #PainManagement #FreeWebinar