Felipe Beckedorff

@itsafiz @UnslothAI @code Nice one! I will give it a try.

Congratulations @thecimminolab @tiff_leesang @john_brabson and others. It was a great pleasure to be part of this work !!! ⁩

New blog post: In Google's new paper, "An AI system to help scientists write expert-level empirical software" an AI supposedly "invents" new methods in bioinformatics and infectious disease modeling & forecasting. doi.org/10.59350/ymjnw… 🧬🖥️🧪

Computational methods for analysing multiscale 3D genome organization go.nature.com/3Lhb4Xb #Review by @zocean636, @LoreBonimba, @muyu_wendy_yang, @NCITomMisteli, @faucla & @jmuiuc @4DNucleome @CMUCompBio @SCSatCMU @UCLA @UCLAQCBio @theNCI

Enhancing transcriptome mapping with rapid PRO-seq profiling of nascent RNA dlvr.it/TMNCmm

Our new paper is out on @MolecularCell !! We show that Integrator complex, is essential for RNA Polymerase II recruitment, pluripotency, and developmental gene regulation in mESCs. sciencedirect.com/science/articl… #StemCells #Transcription #DevelopmentalBiology #RNApolII

Online now: TAF1 is required for fetal but not adult hematopoiesis in mice dlvr.it/TLy1kP

🔬 Science meets leadership. As director of Sylvester, @DrSDNimer leads a powerful network of researchers, physicians and patients while continuing his own work in the lab. In his latest study, Dr. Nimer and colleagues uncovered how a key molecule, TAF1, regulates hematopoiesis. Their discovery opens the door to potential new therapies targeting TAF1. ➡️ The findings were published July 16 in @Dev_Cell. Read more: loom.ly/Y9EjgjU

We introduce rPRO-seq, a rapid and low-input method to map nascent RNA with nucleotide precision — in just 12 hours and from as few as 5,000 cells. sciencedirect.com/science/articl… #RNA #Genomics #PROseq #NascentTranscription #Neurodevelopment #MolecularCell

We have postdoc positions open to study epigenetic mechanisms contributing to resistance to chemo+immuno in TNBC, and projects related to epigenetic determinants of neurodevelopmental disorders. Feel free to reach out to me here/via email. Please like and repost!

Congratulations @MonikaGullerova !!! It was a great collaboration !! A new insight for INTS6. academic.oup.com/nar/advance-ar…

Well. It REALLY happened. The plagiarized paper got published. my paper from 2021 - pubmed.ncbi.nlm.nih.gov/33915259/ new one from 2024 - pubmed.ncbi.nlm.nih.gov/38700052/ We'll look at figures in the 🧵 below.

"Perfection is impossible. In the 1,526 singles matches I played in my career, I won almost 80% of those matches. But what percentage of points did I win? 54% In other words, even top ranked tennis players win barely more than half the points they play. When you lose ever second point on average, you learn not to dwell on every shot. You teach yourself to think: 'Okay, I double faulted...it's only a point.' 'Okay, I came to the net and I got passed again...it's only a point.' Even a great shot, an overhead backhand smash that ends up on ESPN's top 10 playlist – that too is just a point. Here's why I'm telling you this. When you're playing a point, it has to be the most important thing in the world. And it is. But when it's behind you, it's behind you. This mindset is crucial – because it frees you to fully commit to the next point with intensity, clarity, and focus." –@rogerfederer

The Mendel lecture is now online: youtu.be/K0FUs3nWp3c?si…

Cofactors are a crucial part of the gene activation process. Yet, we still don't have a comprehensive understanding of how and why they are used by different genes. Proud to present our attempt to address this key question, now published nature.com/articles/s4158…

We’re excited to announce philanthropist Ken Griffin’s transformative $50M gift to @univmiami. This trajectory-changing donation will fuel groundbreaking #CancerResearch at Sylvester Comprehensive Cancer Center, the only National Cancer Institute (NCI) – designated #cancer center in South Florida. With the Kenneth C. Griffin Cancer Research Building, we’re empowered to expand our research efforts in diagnosis, prevention, treatment and care, accelerating the race to survivorship. #OnlySylvester Read more: bit.ly/3P7iwpr.

Congratulations to twitter less Bonnie Su on her first paper from the lab! Bonnie shows that NELF can bind Pol II in two distinct confrontations that support either pausing or elongation. She did this using actively transcribing complexes. Read it here: authors.elsevier.com/sd/article/S10…

Online Now: Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing dlvr.it/T38kyQ

PRC2 is reported to bind RNA. Yet, genetic experiments have raised serious questions about their functional relevance. Our paper revisits the biochemical evidence supporting widespread PRC2-RNA interactions and finds that many of these do not occur in vivo. tinyurl.com/mr3thkyx

Tetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks biorxiv.org/cgi/content/sh… #biorxiv_molbio