Julia Pagan Lab

Check out our preprint showing that the turnover of NIX and BNIP3 mitophagy receptors via SCF-FBXL4 ligase keeps mitophagy low. biorxiv.org/content/10.110…

Very (very!!) happy to share our latest publication, "PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy", out today in @NatureComms. 1/n nature.com/articles/s4146…

First PhD completed in our lab!! We are so proud of you Dr @DienGiang , your hard work has paid off! 👩🏻‍🎓🥳

Late to the Twitter party, but wanted to highlight this excellent study from @LabPagan that provides fundamental insights into how mitophagy is regulated. An elegant mechanism that puts ubiquitin at the centre stage -this from a pathway that is meant to be ubiquitin independent!

Really, really humbled to have had the opportunity to work closely with @DienGiang on this project! 🧫 Go check out some of the cool things we saw!

Really nice study from the lab of Julia Pagan showing a central role for the F-box protein FBXL4 in ubiquitation and degradation of mitophagy regulators BNIP3 and NIX. @LabPagan. @UQ_News biorxiv.org/content/10.110…

Sylvie Urbe and Michael Clague's group independently discovered the same mechanism and you can read their preprint too! biorxiv.org/content/10.110…

Many thanks to the amazing first authors @DienGiang + @KeriKozul and our wonderful collaborators including @brettcollins100 @LabParton @paganolab @ZurynLab @LazarouLab @Jones_MJK @_AntonioMarzio Robert Taylor @MitoResearch

Check out our preprint showing that the turnover of NIX and BNIP3 mitophagy receptors via SCF-FBXL4 ligase keeps mitophagy low. biorxiv.org/content/10.110…

Moving week for our lab!

A cell videoed through a microscope. DNA in the nucleus (blue), mitochondria (yellow), and the cytoskeletal protein VASP (purple) are shown. #CellBiology #microscopy #SciArt

Join us for this awesome event!

Checkout our paper describing DDK’s role in human replication and fork repair. Online now ⁦@MolecularCell Many thanks to my coauthors ⁦@GelotCam⁩ ⁦@jallepap⁩ ⁦@jespervolsen⁩ authors.elsevier.com/c/1cX5a3vVUPGI…

Love this one 😂

A fun lab celebration playing Christmas themed putt putt @VicParkGC!🎄🎅🏼 Scientists and swinging candy canes were an interesting mix...

A peculiar bacterial enzyme has allowed researchers to achieve what even the popular CRISPR–Cas9 genome-editing system couldn’t manage: targeted changes to the genomes of mitochondria, cells’ crucial energy-producing structures. go.nature.com/2ZtWSTa

Mitochondria, the powerhouses inside cells, have been gene-edited for the first time bit.ly/2ZMzbEs

A handful of genetic and structural analyses have identified a key feature of #COVID19 — a protein on its surface — that might explain why it infects human cells so readily. go.nature.com/3aGqFdQ

News & Views: A process termed ubiquitination mediates the regulated destruction of cellular proteins, thereby preventing disease or infection. Structural data now reveal how a crucial regulator of ubiquitination enzymes coordinates this process. go.nature.com/31UEVfT

A useful review of mitochondrial E3 Ubiquitin Ligase PARKIN: Relationships with other causal proteins in familial #Parkinsons & its substrate-involved mouse models mdpi.com/1422-0067/21/4…

Giang for completed her M1 on Friday! We are so proud of her 🥳