REQUITE

Thanks to patient-derived samples from @RequiteProject, we are going to investigate if #microRNAs from blood are #biomarkers of long-term-side effects of #radiotherapy in #breastcancer and #prostatecancer patients!

"The Green Journal has just published an exciting new article describing the REQUITE project, from idea to present status." bit.ly/2KhTqoc

@CatharineWest3 from @RRR_UoM illustrating risk modelling integrating polygenic risk scores with clinical / dosimetric NTCP data. Large international efforts such as @RequiteProject are essential. #medphys #radonc #ptcog58

Collecting data from 4438 #Cancer patients, the @RequiteProject aims to identify biomarkers for radiotherapy toxicity to improve quality of life. VHIO's involvement led by @SaraGutierrezEn and Radiation Oncology Department from @vallhebron. Read more: vhio.net/en/predictive-…

Very happy to have contributed with @VHIO @vallhebron to @RequiteProject, #Europeanproject recruiting data, DNA and RNA samples from about 4300 #breastcancer #ProstateCancer #lungcancer patients to validate prediction models and biomarkers of radiotherapy-induced side effects

Chris Talbot talking about how circadium rythmn genetic variants affect risk of toxicity when radiotherapy is given am or pm.

Were you involved in the #REQUITE study on radiotherapy @Leic_hospital? A new patient leaflet to say thanks & update you on the progress of the study is available here, in 7 languages requite.eu/node/184 @RequiteProject @hopeagnstcancer

Final REQUITE Dissemination report available! The aim of this report is to provide a final update on the outputs and dissemination activities of the REQUITE consortium. Thanks to the whole consortium including a very active #PatientAdvisoryGroup. see requite.eu/node/202

REQUITE Report on SNP selection online! To report on the genotyping undertaken of blood samples collected in the observational study and processed by the CIGMR biobank. see:requite.eu/node/199 #SNPs #CNVs #RadiotherapyToxicity #PredictionModels.

REQUITE report on patient recruitment available online: requite.eu/node/200 In total, 4,438 patients with breast, prostate or lung cancer were recruited prospectively. 383 additional lung cancer patients were genotyped alongside the REQUITE cohorts. (additional lung cohorts)

Chamberlain Mbah defended his PhD and had the manuscript accepted (September 2018): “Challenges in predicting normal tissue toxicity in radiotherapy”. biblio.ugent.be/publication/85…

We are very proud of Four PhD students who have successfully defended their theses that made use of REQUITE data: see: requite.eu/node/194 Gilles Defraene, Tim Rattay, Kerstie Johnson and Chamberlain Mbah.

Kerstie Johnson defended her PhD and the manuscript accepted (July 2018): “Predicting radiotherapy toxicity in patients treated with radical radiotherapy using predictive assays and circadian rhythm”. lra.le.ac.uk/handle/2381/40…

Tim Rattay defended his PhD and had the manuscript accepted (Febr2018): “Predicting acute radiation toxicity in breast cancer”. This thesis is not currently available. due to an embargo by the REQUITEconsortium that core publications are prioritised above other research/analyses.

Gilles Defraene defended his PhD and had the manuscript accepted (January 2018): “Image based quantification of radiation induced lung damage”. limo.libis.be/primo-explore/…

❗APPLICATIONS FOR PHD PROJECTS ARE NOW OPEN❗ bmh.manchester.ac.uk/study/research… We have a wide range of clinical and non clinical opportunities that will train the science leaders of the future!

@RequiteProject animations highlight a #bettertogether approach to science and how to build cohorts to identify genetic variants that increase risk of radiotherapy toxicity. requite.eu/node/189 requite.eu/node/193

The REQUITE Animation produced @VincentdeMees shows why we founded the @RequiteProject and is available in 6 languages @YouTube: see links on requite.eu/node/193 #ProstateCancer #Breastcancer #Lungcancer #radiotherapy #toxicity #PersonalTreatment

Radiation Therapy after surgery can decrease the chance of cancer returning in the breast and improve survival. Check out our video on Radiation Therapy for #BreastCancer to learn more about this treatment method. #bcsm #breastcancerawareness #radonc ow.ly/6IUg30mcmXf