Bold LaBeouf

Most people have never heard of microdosing iboga. That’s about to change. A man in Germany was diagnosed with early onset Parkinson’s at 41. By 51, he was completely bedfast. As a last resort, he had holes drilled into his skull for deep brain stimulation. It gave him some mobility back but not much. Thirty days later, he signed up for assisted suicide. Before going through with it, he connected with a researcher at the University of Zurich named Tobias Emmery who had been studying ibogaine, a psychoactive compound from a West African plant called iboga. The protocol was an upwardly titrated daily low dose over four weeks. It restored normal motor function, so he left his 24/7 nursing home, moved in with his mother, and was riding a bicycle three miles a day. INSANE! This is one of roughly 50 cases Emmery has studied. The efficacy is around 50% and seems confined to genetically rooted Parkinson’s rather than environmentally triggered cases. It’s not a silver bullet. But for the people it works for, there is nothing else in medicine that comes close. Parkinson’s is just one piece of the picture. Stanford published a study in Nature Medicine showing that a single ibogaine treatment in 30 special operations veterans with TBI produced average reductions of 88% in PTSD, 87% in depression, and 81% in anxiety. The late Dr. Nolan Williams, who led that research, said no other drug has ever been able to alleviate the functional and neuropsychiatric symptoms of traumatic brain injury. Brain imaging revealed neurorestorative effects including white matter regeneration across the brain’s surface, something previously unheard of in medicine. The mechanism appears to involve GDNF, a growth factor that supports the survival of dopamine-producing neurons, which are the exact neurons that degrade in Parkinson’s and other neurodegenerative diseases. This is no longer fringe. Brett Favre is using ibogaine through Ambio’s neuroregenerative program for his Parkinson’s diagnosis and has reported improvements in sleep and energy. Conor McGregor underwent treatment at the same clinic for TBI and trauma and said it saved his life. Texas approved a $100 million initiative to fund FDA clinical trials for ibogaine, one of the largest government investments in psychedelic therapy ever. Ibogaine is still a Schedule 1 substance in the US. But for conditions like Parkinson’s, MS, TBI, and opioid addiction, there is a growing body of evidence that this plant does something to the brain that we don’t fully understand yet and that nothing else can replicate. We may be looking at the most important neurodegenerative medicine that nobody is talking about.

girls will survive horrors beyond comprehension and still give love and light and keep it pushing but a man who had one fuckass breakup at 15 will make it his entire personality and be an asshole forever

People who actually experienced the 1990s: What is something you miss from that decade that just isn't the same today