Is arginine the next frontier in covalent chemistry? We think so! Check out our latest work in collaboration with @IanSeiple where we utilize ninhydrin as a selective warhead and probe for reactive arginines!
Andrew Ecker@EckerChem
Is 2026 the year of arginine? Covalent discovery and chemical proteomics have largely focused on cysteine and lysine, leaving other functionally critical residues underexplored. In our new preprint, our joint Seiple and Zaro Lab team asked: Can arginine be targeted covalently? 🧵
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