Aditya Pimplaskar

Excited to see our work in AJHG! Thank you to our amazing co-authors, UCLA Institute for Precision Health, UCLA CTSI, and our collaborators for the support with this work. Above all, we are grateful to the patients and ATLAS biobank participants at @UCLAHealth.

Interpretability has not kept up with scaling LLMs at all, especially for *knowledge*. But here's a wild idea: using cross-lingual knowledge inconsistency (typically seen as a "bug") as a tool for dissecting where knowledge lives 🧵1/4 arxiv.org/abs/2603.17102 @GoogleResearch

New preprint! We mapped thalamocortical dynamics in human focal epilepsy using SEEG. We found distinct spectral and connectivity based signature that could be direct targets for neurostimulation. With @UCLAMCH and @uclamii medrxiv.org/content/10.648…

"An hour of planning can save you 10 hours of doing." ✨📝 Planned Diffusion 📝 ✨ makes a plan before parallel dLLM generation. Planned Diffusion runs 1.2-1.8× faster than autoregressive and an order of magnitude faster than diffusion, while staying within 0.9–5% AR quality.

Would love to connect/discuss projects w/ folks interested in EHR-based phenotyping methods for genetic studies, psychiatric genetics, and perinatal health! #ASHG25

Excited to visit Boston for #ASHG25. I’ll be presenting our work on the effects of recruitment bias in biobank studies on Friday (10/17) @ board 1126 — please drop by and say hi!

@Hyunkyungkim_ See you in Boston! Excited to hear about your work

Excited to be presenting my poster on SPATULA, a Bayesian matrix factorization framework to dissect pleiotropy & trait-specific effects, at #ASHG25 in Boston! Come find me at poster 1127F — and I’m also looking for postdoc opportunities starting in 2026!

🔦Adaptive Parallel Decoding (APD) has been accepted as a spotlight paper at @NeurIPSConf ! I thank my collaborators, reviewers, and program organizers for this honor. A thread for those interested 🧵 (1/n)

Our work on genetic variants that affect RNA stability is out in @NatureGenet! We present the RNAtracker computational pipeline, which can distinguish between transcriptionally- vs. stability-mediated regulation of gene abundance. bit.ly/42aihk2 (1/n)

@humzalikhan @StanfordDaily linking to the dictionary definition of luddite is such a humza thing to do -- this could never have been written by an LLM (i also love em dashes)

My article about critical thinking and LLM use was just published @StanfordDaily — would love to hear your thoughts! Simply put: reasoning matters, especially when it’s easy to get away without it. stanforddaily.com/2025/07/08/fro…

📣New from @bpasaniuc & co 📄Exploring #depression treatment response by using #polygenic risk scoring across diverse populations cell.com/ajhg/abstract/…

“That’s one small [MASK] for [MASK], a giant [MASK] for mankind.” – [MASK] Armstrong Can autoregressive models predict the next [MASK]? It turns out yes, and quite easily… Introducing MARIA (Masked and Autoregressive Infilling Architecture) arxiv.org/abs/2502.06901

Does ambient RNA/DNA confound the genotype-based demultiplex of 10x Multi-ome data? Terence Li @terencewtli, a bioinfo grad student in Noah Zaitlen lab and my lab investigated precisely this question and provided practical recommendations.

The impact of ambient contamination on demultiplexing methods for single-nucleus multiome experiments biorxiv.org/content/10.110… #biorxiv_bioinfo

Online Now: Single-cell stimulus-response gene expression trajectories reveal the stimulus specificities of dynamic responses by single macrophages dlvr.it/TFMykR

📢Online now! 📰Splicing-specific transcriptome-wide association uncovers genetic mechanisms for #schizophrenia 🧑‍🤝‍🧑@gracexiao99 @bpasaniuc & colleagues cell.com/ajhg/fulltext/…

Excited to share that our paper: "Uncovering spatiotemporal dynamics of the corticothalamic network at ictal onset" is out in Epilepsia! with Hiroki Nariai, Atsuro Daida, Shingo Oana, @BillSpeier, @uclachildneuro, et. al bit.ly/3walCTu (1/4)

I’ve been advised to put up a poll

Settle a debate for me (and some friends): is a tent flap considered a door?

My first first author paper is now online with @BiologicalPsyc1! We compared two sets of MDD symptoms and found that current symptoms collected by PHQ9 are meaningfully different from lifetime symptoms collected through CIDI-SF. (1/n)