Blindfold Capital

Trump never misspells anything, multiple grammar issues in this. Account might have been hacked, but if true, don’t really know what talks we were having and how this makes any sense when Netanyahu was talking about taking out Iran’s infrastructure this weekend.

why is population dropping? Because there are less babies why are there less babies? because there are less couples why are there less couples? because now we demand a much higher threshold for coupling up. Love is the minimum threshold for coupling up or else people (women) will prefer to stay alone the problem is love is rare. it always has been.

A new shot literally regrows knee cartilage. Researchers at Stanford Medicine have identified a novel strategy to regenerate articular cartilage in knees and potentially prevent or treat osteoarthritis (OA). The method targets 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an age-related enzyme—or "gerozyme"—that accumulates in aging tissues and drives degeneration. In aged mice, small-molecule inhibitors of 15-PGDH, delivered systemically or via intra-articular injection, promoted cartilage thickening and regeneration of functional hyaline articular cartilage. This occurred without recruiting stem or progenitor cells; instead, existing chondrocytes underwent transcriptional reprogramming to a youthful state, with reduced populations of inflammatory and hypertrophic/degradative cells and expanded matrix-producing articular chondrocytes. The inhibitors also reversed natural age-related cartilage thinning, improved joint function, and—when administered after simulated ACL injuries—strongly mitigated post-traumatic OA progression and associated pain. Human OA cartilage explants from total knee replacements responded similarly in vitro, showing decreased degradation markers and evidence of new articular cartilage formation. Given that an oral 15-PGDH inhibitor has already completed Phase 1 safety trials for age-related muscle atrophy, the findings open a path toward disease-modifying, regenerative therapies that could delay or obviate the need for joint replacement surgery. [Agarwal, P., Su, S., Ancel, S., et al. (2025). Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration. Science. DOI: 10.1126/science.adx6649]

I'm increasingly sensing that "people who get really good at AI will survive & thrive" is likely a cope It doesn't require much skill, obviously it will also require less & less skill...I don't think any 'edge' you have today as a mere AI 'power user' will last long...