Derda Lab

218 posts

Derda Lab

@derda_lab

Genetically-encoded discovery are the heart of Derda Lab. A diverse and dynamic group located at UAlberta working on #phage #peptides & #glycans

Alberta, Canada 参加日 Nisan 2019

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Ratmir Derda@RatmirDerda·23 Oca

To distract everyone from the devastating NIH news, I recommend reading this Mirror Image Life discussion in Science magazine science.org/doi/10.1126/sc… or popular press cbc.ca/radio/thecurre… and our view on this topic: TLDR: do not forget about Glycans! biorxiv.org/content/10.110…

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Cell Chemical Biology@CellChemBiol·22 Kas

The liquid lectin array detects compositional glycocalyx differences using multivalent DNA-encoded lectins on phage by Guilherme Meira Lima, @RatmirDerda @derda_lab, et al. at @UAlberta @StanfordUChem @usponline dlvr.it/TGL3vq

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Guilherme Meira Lima@Guilher63551077·25 Eki

Excited to share our latest work on DNA-encoded liquid lectin array! This work would not have been possible without the amazing support and contributions of my colleagues at the University of Alberta!

Ratmir Derda@RatmirDerda

@CellChemBiol publication of Liquid Lectin Array (LiLA) led by Guilherme Meira Lima (scholar.google.com/citations?user…) PhD Student from @derda_lab and co-authors from @MatthewMacaule4 Lab, @glycocode (Lara Mahal), Raymond Lai et al, now in cell.com/cell-chemical-…

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Cell Chemical Biology@CellChemBiol·25 Eki

Online now! The liquid lectin array detects compositional glycocalyx differences using multivalent DNA-encoded lectins on phage by Guilherme Meira Lima, @RatmirDerda @derda_lab, et al. at @UAlberta @StanfordUChem @usponline dlvr.it/TFkMqZ #chembiol

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GlycoNet@glyconet_nce·24 Eki

Congrats to all the GlycoNet researchers on their paper about the liquid lectin array (LiLA), which uses DNA-encoded #lectins to detect subtle glycocalyx differences and enhance our understanding of #glycan composition. @derda_lab @MatthewMacaule4 @glycocode @miratsojitra

Ratmir Derda@RatmirDerda

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Ratmir Derda@RatmirDerda·24 Eki

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Mirat Sojitra@miratsojitra·24 Eki

The Liquid Lectin Array (LiLA) paper is out in @CellChemBiol. Congratulations to @Guilher63551077 for this amazing publication and it was my privilege to play a [small] part in this project. #Siglec #Glycotime #Phage #Glycans cell.com/cell-chemical-…

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Nature Protocols@NatureProtocols·23 Eki

#FeaturedProtocol this week: #Liquidglycanarray (LiGA) platform to profile #glycan-lectin interactions on the surface of live cells bit.ly/4hjtZyE #Glycotime #Siglec

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GlycoNet@glyconet_nce·17 Eki

Congrats to the GlycoNet team on this important research that advances our understanding of how glycans interact with proteins on live cells using the LiGA platform! @miratsojitra @RatmirDerda @MatthewMacaule4 @ednschmidt @Guilher63551077

Mirat Sojitra@miratsojitra

Excited to report that protocol for DNA-encoded, Liquid Glycan Array (LiGA) is out in @NatureProtocols. In addition to the protocol, we report how the expression level of Siglecs and cell types affect their ability to bind to LiGA. nature.com/articles/s4159…

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Mirat Sojitra@miratsojitra·16 Eki

A big thank you to @RatmirDerda and @MatthewMacaule4 for their mentorship! This wouldn't have reached the finish line without a lot of help from @Guilher63551077 @ednschmidt, Kelli (Macauley lab) and all past and presents members of @derda_lab

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Ratmir Derda@RatmirDerda·16 Eki

DNA-encoded, Liquid Glycan Array (LiGA) and its application to cell-surface profiling is out in @NatureProtocols . Big thanks to @miratsojitra for leading the effort and @MatthewMacaule4 + members of Macaluley Lab and @derda_lab ! rdcu.be/dXaNJ

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Ratmir Derda@RatmirDerda·15 Ara

I'm curious about any feedback from #Glycobiology #glycan #carbohydrate #glycotime community on @derda_lab preprint on DNA-encoded liquid #lectin arrays (LiLA). [LiLA] non-lineary amplifies detection of compositional differences of the cellular #glycocalyx biorxiv.org/content/10.110…

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Derda Lab@derda_lab·7 Eki

@S_Schetters @miratsojitra @ednschmidt @Guilher63551077 @MatthewMacaule4 @RatmirDerda @bart @S_Schetters We focused on Siglecs in this pre-print, but it would be cool to see how LiGA can be applied to Galectins. Let's talk offline about it further?

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Sjoerd@S_Schetters·6 Eki

@derda_lab @miratsojitra @ednschmidt @Guilher63551077 @MatthewMacaule4 @RatmirDerda Awesome! What about galectins, like Gal10? @bart

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Derda Lab@derda_lab·6 Eki

Delighted to share the pre-print of a LiGA protocol with detailed instructions to profile the glycan binding preference of cell surface #Siglecs using #ngs #glycotime Shout out to @miratsojitra @ednschmidt @Guilher63551077 @MatthewMacaule4 @RatmirDerda biorxiv.org/content/10.110…

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Derda Lab@derda_lab·6 Eki

This protocol follows previous publication from our lab describing ways to synthesize LiGA using synthetic glycans (doi.org/10.1038/s41589…) or direct chemoenzymatic synthesis of N-glycans on phage (doi.org/10.1038/s41467…) Check it out!

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Derda Lab@derda_lab·29 Ağu

Exciting news from @tracy6528! 🎉 Check out her latest paper on 'Chemoenzymatic synthesis of genetically-encoded multivalent liquid N-glycan arrays' available online now. 📚🔬 nature.com/articles/s4146…

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Duong Bui@Duong_T_Bui·28 Tem

Congratulations to our friend @miratsojitra who is now officially Dr. Sojitra. We are so proud of you. People will talk about how great you are as a scientist but we (Ann and me) will always remember you as our great friend.

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Peter Seeberger@peterseeberger·26 Haz

Here we show that peptide-glycan chimera can be made on the same instrument on solid support. Next, an instrument to make #glycopeptides for #glycotime studies will be revealed.

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Derda Lab@derda_lab·19 May

Today is the last day of our intern Allison. It's so nice to have you in our group for the past 4 months. All the best to your future adventures!

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Mike Downey@MichaelDowney10·6 May

Really proud to have worked with this guy and to have watched him grow both as a scientist and as a human being over his undergrad career. Congrats, @ryannqiu! :)

Derda Lab@derda_lab

Congratulations to our superstar undergrad @ryannqiu for winning the best oral presentation award at the #wcucc2023!!! Very well deserved for all his hard work and dedication.

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ディスカバー

@RatmirDerda @UAlberta @StanfordUChem @usponline @miratsojitra @CellChemBiol @Guilher63551077 @ednschmidt