Jean-Ehrland Ricci

Why does IRE1 sometimes promote tumors and sometimes fight them? We identify DPM1 as the rheostat controlling IRE1 activity. Low DPM1 sustains immunogenic IRE1 signaling, enhances CD8+ T-cell surveillance, and predicts better immunotherapy responses. nature.com/articles/s4146…

Check how their findings demonstrate that PRMT6-dependent EZH2 methylation plays an important role in driving breast tumour growth, revealing a new epigenetic mechanism of PRMT6 in the breast cancer and highlighting PRMT6 inhibition as a potentially therapeutic strategy.

“PRMT6-mediated EZH2 arginine methylation is critical for breast cancer development” 🔵 Zhenhai Yu‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: nature.com/articles/s4138…

Check how this study suggests that combining stemness gene intervention with TKIs may be a viable approach for treating FLT3-ITD+ AML and other tyrosine kinase-mutated leukemias.

“FLT3 inhibition upregulates OCT4/NANOG to promote maintenance and TKI resistance of FLT3-ITD+ acute myeloid leukemia” 🔵 Interesting research led by Yaming Xi was featured in #Oncogenesis. ▶️ Read the full open access article here: nature.com/articles/s4138…

Are we using the scarce ERC money in the most efficient way? I argue in the Times Higher Education (THE) that this may not be the best distribution for keeping talent in Europe:

Check how this study identifies a previously unrecognized regulatory mechanism whereby cholesterol metabolic pathway drives TNBC lung metastasis through the SCAP-SREBP2-CCDC25-NETs signaling axis.

“SREBP2 regulates CCDC25 expression and promotes tumor metastasis in Triple-Negative Breast Cancer” 🔵 Jian Zhao‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: nature.com/articles/s4138…

Check how their study suggests that the secreted free form of ISG15 enhances glycolytic reprogramming in fibroblasts, through CD11a, by increasing glucose consumption and lactate production, as well as recruiting fibroblasts to the TME.

“Tumor cell-derived ISG15 promotes fibroblast recruitment in oral squamous cell carcinoma via CD11a-dependent glycolytic reprogramming” 🔵 Interesting research led by Ya-Wen Chen was featured in #Oncogenesis. ▶️ Read the full open access article here: nature.com/articles/s4138…

Check how authors propose a new therapeutic strategy centered on targeting downstream effectors of GPX3, particularly HIF-1α, to simultaneously suppress gallbladder cancer aggressiveness and reinforce anti-tumor immunity.

“GPX3 suppresses gallbladder cancer progression by modulating redox balance, glycolysis, and anti-tumor immunity” 🔵Impressive research led by Binglu Li is now available to read in #Oncogenesis. ▶️ Read the full open access article here: nature.com/articles/s4138…

Excellent and highly insightful review - A must-read for researchers interested in lymphoma and cancer metabolism. Thank you Chris for contributing to our special issue in @Oncogenesis on « metabolism and cancer » nature.com/articles/s4138…

Check how their study established an enabling role for rapid metabolic adaption in cells that switch on RAS mediated oncogenic pathways, which provides possible effective tumor prevention strategies for humans with RAS driven cancer predisposition syndromes.

“Preneoplastic cells switch to Warburg metabolism from their inception exposing multiple vulnerabilities for targeted elimination” 🔵 Interesting research led by Yi Feng was featured in #Oncogenesis. ▶️ Read the full open access article here: nature.com/articles/s4138…

Check how authors describe a new mechanism for the macrophage M2-mediated bystander effect which suggests a role for activated macrophages in colorectal cancer initiation and progression and offers potential new approaches to prevention.

“Alternatively activated macrophages cause DNA damage through an arginase 1-mediated bystander effect and promote epithelial cell transformation” 🔵 Mark M. Huycke‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full article here: nature.com/articles/s4138…

Check how Jagged1-mediated Notch signaling promotes basal-like breast cancer while exerting a tumor-suppressive role in the luminal compartment of the mammary epithelium, highlighting the differential roles of Jagged1-mediated Notch signaling across breast cancer subtypes.

“Subtype-specific role for Jagged1 in promoting or inhibiting breast tumor formation” 🔵 Interesting research led by Keli Xu was featured in #Oncogenesis. ▶️ Read the full open access article here: nature.com/articles/s4138…

Check how Morusinol’s inhibition of M2-like polarization of macrophages by FUT8, a fucosyltransferase, may hinder tumor-supportive conditions, leading to reduced tumor growth in DLBCL.