Are there any resources detailing which constructs work best with #PyPy ? Which is better: a closure, an equivalent partial(), or an equivalent class? Is indexing preferred over iterators or vice versa? Speed differences between globals, locals, instance vars, class vars, etc?

How does one design their code to make it as PyPy friendly as possible?

@raymondh Write all 3 as microbenchmarks and benchmark them. That's what I do for JavaScript JITs.

@TopTierPython Surely, someone has done this already and has published the best practices.