Basler Lab

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Basler Lab

Basler Lab

@Basler_Lab

Unraveling the secrets of bacterial injection needles .. (among other things)

Basel, Switzerland 가입일 Ağustos 2010
13 팔로잉1.9K 팔로워
Basler Lab
Basler Lab@Basler_Lab·
Thank you, Katrin (@biozentrum) for a great summary of our paper! You can also check out this "Behind the Paper" written by @ATejadaArranz: communities.springernature.com/posts/mechanis…
Biozentrum, University of Basel@biozentrum

New research by @Basler_Lab reveals a surprising microbial trade-off: The bacterium Pseudomonas aeruginosa activates a general defense program to survive “speargun” attacks from rival bacteria, but this defense makes it more vulnerable to antibiotics. 👇biozentrum.unibas.ch/news/detail/ho…

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Basler Lab
Basler Lab@Basler_Lab·
Update to BacFighT6, with presets for easy exploration of complex behaviors: sites.google.com/view/bacfight6 Try "battle royale" preset where prey (blue) produce capsule, attackers (red) move towards prey and feed on it, defenders (orange) retaliate! Took a while to eliminate the reds!
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Basler Lab
Basler Lab@Basler_Lab·
The prey (blue) multiply, don't move and produce capsule (purple). The predators (red) move towards prey and attack non-kin. They divide only if they lyse prey. The defenders (orange) move randomly and defend themselves by retaliation (divide if they lyse a cell). Who wins?
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Basler Lab
Basler Lab@Basler_Lab·
Check out the NotebookLM powered interactive Q&A: sites.google.com/view/bacfight6… This is based on the scientific literature and the simulation code. Literature is cited in the help and the documentation. Extremely helpful!
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Basler Lab
Basler Lab@Basler_Lab·
Major update to BacFighT6: sites.google.com/view/bacfight6/ Simulate the role of motility/chemotaxis, capsule production, activation by autoinducers, contact dependent killing, kin-exclusion, foraging and more. Long simulations, extensive data import/export and analysis. Interactive Q&A!
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Basler Lab
Basler Lab@Basler_Lab·
Poke bacteria with a sharp needle and they poke back in just a few seconds! Congratulations to Mitchell (and others) for this analysis of Pseudomonas #T6SS assembly in response to membrane damage! Collaboration with Rod Lim's lab @biozentrum + @SNIunibas! science.org/doi/10.1126/sc…
Basler Lab tweet media
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Basler Lab
Basler Lab@Basler_Lab·
For over 10 years, we've known that neighboring P. aeruginosa cells engage in rounds of H1-T6SS firing. It was unclear how this starts since H1-T6SS only fires in response to an attack. Now we know: journals.asm.org/doi/10.1128/mb… Congrats Max, Sharath, Alejandro, and others!
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@biozentrum @ATejadaArranz @NCCR_AntiResist @JenalLab @NatureRevMicro @jan_wohlfarth @DannyJamesWard @Joana_MPereira