Cell Stem Cell

Check out the January 2026 issue of #CellStemCell cell.com/cell-stem-cell… On the Cover: Kiral and Yang et al. introduce human pineal gland organoids that naturally produce melatonin and respond to noradrenaline, providing a platform for studying circadian biology.

Online Now! Species-specific chromatin architecture and neurogenesis mediated by a human enhancer dlvr.it/TRb4Fx #stemcells

Online Now! Auditory activity sustains adult neurogenesis and cognition through the locus coeruleus-norepinephrine system dlvr.it/TRb1Wv #stemcells

Online Now! Paired patient-derived organoids reveal transcription factor-driven epigenetic remodeling in breast cancer metastasis dlvr.it/TRWlqs #stemcells

Online Now! In vivo CAR-Tfh cell reprogramming restores tolerance in a mouse model of autoimmune hepatitis dlvr.it/TRT9L9 #stemcells

Neuronal VIP shapes intestinal stem cell activity and mucosal immunity dlvr.it/TRP282

Cradles for maturation: Turning progenitor cells into functional intestinal epithelium dlvr.it/TRNwcC

Off-the-shelf CAR natural killer progenitor cell therapies are built to last dlvr.it/TRNrZS

Tissues assemble! Rebuilding the human periportal liver in a dish dlvr.it/TRNfs2

Two decades of induced pluripotent stem cell research: From discovery to diverse applications dlvr.it/TRLS3c

Adult neurogenesis: New neurons, new opportunities dlvr.it/TRLMGm

Modeling human prenatal adrenocortical functional zonation dynamics from pluripotent stem cells dlvr.it/TRLHmF

Randomized phase 2b dose-escalation trial of stem cell therapy with laromestrocel for aging frailty dlvr.it/TRL6Xk

Pluripotent stem cell-derived CAR-NK progenitor therapy targets minimal residual disease and prevents relapse in leukemia models dlvr.it/TRKLwy

Minimizing far-extending chromatin perturbation in genome editing preserves stem cell identity dlvr.it/TRKJTV

comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders dlvr.it/TRKFgL

Distinct spatial patterning and transcriptomic landscapes of human neural organoids by localized delivery of morphogens dlvr.it/TRKD6D

VIPR1 acts as an enteric neural checkpoint that suppresses intestinal stem cell-driven epithelial regeneration and exacerbates colitis dlvr.it/TRK9rz

20 years of Yamanaka stem cell factor research culminates in 2 conditional approvals for heart disease and Parkinson's disease in Japan sciencedirect.com/science/articl… by Shinya Yamanaka @CellStemCell science.org/content/articl… @ScienceMagazine

Thrilled to share our new paper on Cell Stem Cell!🧬 We generated pluripotent stem cell–derived human adrenal tissue with functional zonation, recreating key features of adrenal cortex 3D organization and steroidogenic function. A powerful new platform to study stem cell biology, adrenal development, disease, and future regenerative therapies. cell.com/cell-stem-cell… authors.elsevier.com/a/1mjFV_h-CqVZ… Kudos to Michinori Mayama and the team for this achievement. @IRM_UPenn @Penn @pennvet @MayamaMichinori @DavidGStouffer1 @coeff_giving @NIDDKgov @jsps_sns @CellStemCell

Our March is live! 20 years after the discovery of iPSCs, Shinya Yamanaka reflects on how reprogramming reshaped stem cell science and where the next breakthroughs may emerge. Read the 20th anniversary Perspective: cell.com/cell-stem-cell… And the issue: cell.com/issue/S1934-59…