Sally struthers returns

@kainvests How do 3.19 million shares get purchased and no pop in price?

$IOVA And I’m definitely not the only one buying the dips 😉

$IOVA Dip bought and added in a separate investment account where I’ll be holding shares beyond 2027/2028. The weekend is here, time to disconnect and live a little. 🤍

In a landmark medical technology milestone, a fully autonomous AI-powered robotic dentist — built by US company Perceptive — completed a full crown preparation on a human patient in just 15 minutes. The same procedure typically takes a human dentist 2–2.5 hours. The robot used real-time 3D scanning, AI decision-making, and a precision robotic arm to perform the entire procedure without any human guidance or intervention mid-surgery. This isn't a concept or prototype — it's already been performed on real patients and a peer-reviewed study was published in the Journal of Dentistry in January 2026. Experts say this is the beginning of a transformation: robotic dentists could eliminate human error, work at any hour, and eventually bring high-quality dental care to remote and underserved communities where trained dentists are unavailable. The dental office of 2035 may look very different from today's.

$IOVA is a gift at the current levels $3.80-$4. It will be over $10 by end of year. There are so many massive catalysts coming. Most importantly, Amtagvi adoption is accelerating and that means when NSCLC is approved sales will be through the roof. The sales and marketing infrastructure is already being built and fine tuned with the advanced melanoma indication. It will be a well oiled machine soon. Patience…

$IOVA - More hiring happening almost on a weekly basis. Amtagvi demand acceleration? Nah, they just hire new people for fun.

@BIOTECHSCANNER Amazing year ahead! The Q4 was my biggest prove for $IOVA in 2026 and beyond ☝🏽

$IOVA - These numbers are staggering. 234,600 new cases in the US ALONE. Iovance will be there. This is why I don’t ever worry about “competition.” We actually need more treatment options to meet demands. It’s about the patient first and foremost. Remember, 90% of all new cancers are solid tumors. $IOVA can’t do it alone. Iovance Biotherapeutics is becoming a household name in this space. 2026 and beyond will be amazing for this company and the patients who will be saved! Iovance will become big pharma soon.

$IOVA Taking a look at Iovance thru the lens of current world events: 1) Higher oil prices - energy is a very small input for Iovance so no impact on margins 2) Tariffs - manufacturing is in US and infrastructure built out to handle 5,000 patients/ year so no need for material rise in input costs 3) War with Iran/potential recession - Amtagvi approved and all treatment in US so world events limited. Cancer does not wait for a war to end or for the economy to improve. Healthcare and biotech are usually the safe haven when the market gets dicey because they are, for the most part, a non-cyclical sector.

@YodaStockInvest $IOVA

$IOVA (L) 30-40% pullbacks in strong momentum names are some of my favorite entry setups. That said, $XBI looks like it's rolling over here, so broader market risk is high. Love $IOVA though; if Amtagvi proves out in NSCLC later this year, the sky is the limit

$IOVA We thought the week was set, but it wasn’t! Last week we discussed about Immutep discontinuing their NSCLC trial, a near direct competitor to Iovance’s TIL therapy. And here we are today before the news that this time it is AstraZeneca discounting a trial that could have been direct competition to TIL in the solid tumour realm. Things are aligning across the board! Internally and externally. And here we are, in a Triple Witching day that could bring us further discounts! Source: fiercebiotech.com/biotech/pfizer… 🤍 Thank you babariaron on StockTwits for the awesome share!

$IOVA- looks ready for a violent rebound here

@Henry431171040 @BiotechAutist @Investorclimber Absolutely but short term could create a dip. I think it two years they will struggle on the supply side unless they get bought out. Demand will be so massive.

@Dancingtapas @BiotechAutist @Investorclimber They also will only compete for 2l so once tilvance 301 is unlocked , its a nothing burger

$ALDX Boom

@KingachillesE @A_May_MD They finally started to have decent margins in 2026.

@A_May_MD I’m with you on COGS being an issue, however still early days. They have tightened things up in terms of process. As you note it’s quite complicated. I am a trader in this name mostly (because of opportunity), but long term investor as well. THIS MOVE IS OVERDONE.

If you’re long $IOVA and only listening to the permabull biotwitter cult leading pumpers who won’t stop tweeting about how positive the earnings results were, you may be wondering why you’re down 20% right now. Well, it *does* happen that stocks irrationally trade down on good news sometimes. But you may want to be open to the idea that the earnings actually weren’t positive and take a look at how expensive these $IOVA revenues are. Especially the fact that $8.3M was “wasted” on manufacturing Amtagvi that was never given to patients. This is an EXTREMELY intense and complicated regimen to administer. There will be manufacturing failures, people will drop out electively or even die during preconditioning (or from advanced disease) before getting Amtagvi. The result of these problems is spending a LOT of money on making product that never generates any revenue. A double whammy. Sure, total revenue exceeded some sellside projects this quarter. But that $8.3M loss just on “wasted” manufacturing accounts for almost 20% of all Amtagvi revenues on the quarter! How many sellside projections have $IOVA immediately dumping 20% of Amtagvi revenue into the trash? Not good. Quit listening to the permabull pumpers and consider that it’s possible things actually aren’t going well. Fingers crossed for good NSCLC data this weekend, which could certainly turn things around if resoundingly positive.

@Henry431171040 @BiotechAutist @Investorclimber The only potential competition is Repl a little bit for melanoma

@Dancingtapas @BiotechAutist @Investorclimber Yeah 10Bil potential for Iovance. Crazy thing is Immutep gave up NSCLC study, AstraZencea failed their NSCLC . Iovance has no competitor aka the first and only immunotherapy if approved in 2027.

@Henry431171040 @BiotechAutist @Investorclimber Agreed just wondering how much cash to have on the sidelines for the possibility of that bump caused by the noise. Have a nice position already.

@Dancingtapas @BiotechAutist @Investorclimber This will be 12+ anyways the moment it filed sBLA for NSCLC so. All esle is noise and opportunity to buy. Teens is inevitable

@BiotechAutist @Investorclimber If Repl gets rejected Iova should get a pop and vice versa

@Investorclimber Thanks bro!

@mahasr199 @JPZaragoza1 That's possible but it's so much speculation and unless you're a real insider hard to know.

@JPZaragoza1 Considering they submitted the exact same data is their any risk it was mostly padzur pushing the CRL and rest will now just go for it?

$REPL advancing a bit pm. Guess it's because Cantor's note with a positive tone for approval after meeting with mgmt. They "came away incrementally more positive in the likelihood of approval". I view the reasons for optimism as fairly weak in particular that their sales team is "pumped about a potential launch" and the support from the melanoma community (?). The roles of Prasad and Pazdur in the CRL and the presenced of new team members at the FDA involved in the review remain speculative. I expect another CRL.

@OldGoldHawkeye @Heatlamp11 @jy201506 You believe Repl gets approved?

@Heatlamp11 @jy201506 This analysis is more logical than the analysis that went something like: because FDA accepted the response as complete, strong likelihood that approves. I have no position in $REPL.

$IOVA another key catalyst coming up is the PDUFA date of April 10, 2026 for $REPL's RP1+Nivo Combo in Melanoma I think 80% chance it will be another CRL and 20% chance it gets approved with a narrow label. Most likely FDA would want "a single adequate and well‑controlled" phase 3 to support RP1's approval. Here are why: FDA already issued a CRL stating the dataset was not an adequate & well-controlled investigation → that is a high-bar deficiency, most difficult to fix relative to other reasons such as CMC. Core issue = interpretability, driven by heterogeneous “post-PD-1” population (adjuvant relapse mixed with true refractory metastatic pts). Single-arm + heterogeneous population = unclear effect size → classic scenario where FDA pushes for randomized evidence. Single-arm registration is most persuasive in true salvage/no-good-options settings (such as Amtagvi's registration trial population in 2L+ Melanoma). In RP1's phase 2, many patients haven’t had CTLA-4 (or aren’t clearly ineligible), there’s a credible active alternative → randomization becomes more appropriate. Recent FDA messaging: one pivotal trial is fine — but must be clean & interpretable → this cuts against weak single-arm packages. FDA doesn’t always finish CMC review if efficacy already blocks approval. Absence of CMC in the first CRL ≠ CMC cleared. Resubmission often triggers deeper CMC review + inspections

@MartinShkreli thoughts on $IOVA?

@Mahmissa Honestly never know but not sure what's taking so long. Just approve it if you're going to approve it.

@Mahmissa Fda has all the same data and keeps waiting the trial design probably sinks them

Surprised at $REPL weakness. Thought it'd be a little more robust into the PDUFA.