Eva Notari

Coxon Lab (Edinburgh) reports hydrocarbon‑stapled peptides targeting the CGRP receptor, enhancing stability & maintaining activity, advancing the design of metabolically robust peptide therapeutics. #JMedChem go.acs.org/dTY

Wells Wood Lab protein design landed in top 1.2% in Adaptyv Nipah Virus Protein Design Competition in which 680+ participants submitted over 10,000 designs. This was a great team effort with @EvaNotari, @DrLeucine , @mjstam, and @s_mert_unal @ChrisWellsWood

All designs were scored with MD magic from @EvaNotari and our very own "Stam score" (@mjstam ), and we filtered out any candidates that showed non-specific co-folding. Fingers crossed for the lab experiments!

We (@ChrisWellsWood Wood's lab) have taken the lead at the @adaptyvbio competition against the Nipah Virus! Give us your ⭐️ for our other designs here: proteinbase.com/collections/ni…

We are pleased to announce drMD: Molecular Dynamics for Experimentalists! Read the paper at: sciencedirect.com/science/articl… Get the code from: github.com/wells-wood-res… #proteins #moleculardynamics

New Communication out NOW from @CampopianoGroup, @ArtOxiZymes, @jarvis_lab, @EdinburghChem #openaccess 'Installation of an organocatalyst into a protein scaffold creates an artificial Stetterase' buff.ly/4i6EDsY

Congratulations Alice and all involved! 📰🥼👩‍🔬 @ArtOxiZymes, @CampopianoGroup, @Brew_Richard, @ChrisWellsWood, @klemencic_eva, Mert and Evangelia

Congrats to Alice on publishing her PhD work in Chem Comm. The first example of a NHC-modified protein displaying Stetterase activity! Great work. @ArtOxiZymes @EdinburghChem pubs.rsc.org/en/content/art…

drMD: Molecular Dynamics for Experimentalists biorxiv.org/cgi/content/sh… #biorxiv_bioinfo

We are pleased to announce the release of The Protein Design Archive. Our comprehensive database of designed proteins highlights the triumphs and challenges of the field: pragmaticproteindesign.bio.ed.ac.uk/pda/ Preprint:biorxiv.org/content/10.110… @mjstam @MartaChronowska @WoolfsonLab #proteindesign

New paper in PLoS Comp Biol! @jack_oshea97 used molecular dynamics to find sites for cpGFP insertion, creating functional biosensors in a periplasmic binding protein. He identified known sites but also discovered new ones, which he validated in the lab. journals.plos.org/ploscompbiol/a…

Last week I presented my research on predicting the oligomerisation states of coiled coil proteins with MD simulations at the annual Joseph Black conference organised by @EdinburghChem. Very pleased to have received an award for the best oral presentation in Physical Chemistry.

New preprint out!🚨We performed a large scale analysis of physicochemical features extracted from over half a million AlphaFold structural models, and using data-driven methods we showed a link between these features and in vivo behaviour of proteins. Find out more below⬇️1/9

🍻I will be giving a @pintofscience talk titled "How to Create a Protein" on May 14 in Edinburgh! 🍻 pintofscience.co.uk/event/revoluti…

#pint24 is live! If in Edinburgh, come and join me at Bar50 on May 13 for a night of 🔬🧪🧬 and some 🍺🍺! Sneak peek...I will talk about "kinetoplast DNA" 🧬🪢 and how bloodsucking parasites are tech-ing us out 👀 pintofscience.co.uk/event/technica…

If you're in #Edinburgh this May, why not pop along to @pintofscience to learn about some of the ways current research is revolutionising healthcare? Join us on May 14th for a 🍺 and some 🧪, and find out how I'm trying to make peptide drugs more sustainably! #pint24 #TechMeOut

Very happy to have collaborated with @AdamSchofield__ @Dr_CR_Coxon on optimising a HPLC focused gradient for peptide purification. Check our application note below🧪

Not sure how many people that follow me use CCBuilder, but it has been down due to computer issues. I'm pleased to say that it is now back online at a new URL with some minor updates: pragmaticproteindesign.bio.ed.ac.uk/builder/ @WoolfsonLab

I had a fantastic experience in giving an oral and poster presentation at #PPSG2023 about new #migraine treatments. Very honoured to win best poster! Well done to everyone giving talks and posters today. Now let’s hope #StormBabet calms down so I can get home… @RSC_PPSG

@EastbioDTP PhD opportunity ''Multifidelity simulations for high-throughput generative protein engineering pipelines'' collaboration with @DrStracquadanio @EdinburghUni findaphd.com/phds/project/e…