HagnLab

@HelmholtzMunich Great symposium that goes beyond simple structures

#BNMRZ Symposium 2025 🔬 Ultra-Highfield NMR and 4D Structural Biology – From Mechanisms to Therapies 🤩How do molecules breathe, and what does the fourth dimension in 4D structural biology refer to? 👉 These questions and more fascinating insights about ultra-highfield #NMR will be discussed by world-leading experts in Munich November 6-7, 2025! When & where: 📅 Thursday & Friday, November 6–7, 2025 💻 Online attendance: Registration for on-site participation is closed, but you can still join via webinar – simply fill in the online participation form: 👉t1p.de/zdr8j Prof. Michael Sattler, Dr. Reid Alderson, Prof. Steffen Glaser, Prof. Franz Hagn, Prof. Bernd Reif, and Prof. Anne Schütz are looking forward to sharing this exciting journey into the future of biomolecular NMR and structural biology! The #symposium is hosted by #HelmholtzMunich and the Technical University Munich. Check out what Michael Sattler is already revealing about the conference: 📽️Watch the video below! ⬇️ 👉 Further information: t1p.de/rjuz4 @TU_Muenchen #StructuralBiology #CryoEM #AI #TherapeuticInnovations

@HelmholtzMunich Thanks to Helmholtz Munich for promoting our work !

New Switch for Natural Cell Death Identified 🧬 👉 t1p.de/3fxvc Programmed cell death (#apoptosis) is a vital protective mechanism, but cancer cells often bypass it. A team at #HelmholtzMunich and the Technical University of Munich, led by Prof. Franz Hagn, has now uncovered a new molecular switch in this process. 💡 Their study shows that the mitochondrial protein VDAC1 can override the apoptosis inhibitor Bcl-xL under cellular stress, effectively activating cell death. Using cutting-edge techniques like NMR, X-ray crystallography, and cryo-EM, the researchers revealed exactly how this interaction works. This discovery opens the door to potential therapeutic strategies: 💠 Cancer: Enhance VDAC1 to drive tumor cells to die. 💠 Neurodegenerative diseases: Inhibit VDAC1 to protect neurons. 💠 Heart disease: Modulate apoptosis to prevent tissue damage. 🌟 While clinical applications are still in the future, this work provides critical insights into nature’s own cell death regulation. 🔗To the original publication: t1p.de/jqhuo @TU_Muenchen @NaturePortfolio #CellDeath #CancerResearch #Alzheimer #Parkinson #Neurodegeneration #PrecisionMedicine #HeartDisease #BNMRZ

The 2024 #NobelPrize laureates in chemistry Demis Hassabis and John Jumper have successfully utilised artificial intelligence to predict the structure of almost all known proteins. In 2020, Hassabis and Jumper presented an AI model called AlphaFold2. With its help, they have been able to predict the structure of virtually all the 200 million proteins that researchers have identified. Since their breakthrough, AlphaFold2 has been used by more than two million people from 190 countries. Among a myriad of scientific applications, researchers can now better understand antibiotic resistance and create images of enzymes that can decompose plastic. Read more about their story: bit.ly/3XI7KK3

The Nobel Prize in Chemistry 2024 nobelprize.org/prizes/chemist… #Protein #design and #structure #prediction. Special congrats to our TUM Distinguished Affiliated Professor David Baker! @TU_Muenchen

Happy and proud to have been part of the Ferienakademie of the @TU_Muenchen @UniFAU and @Uni_Stuttgart in the beautiful Sarntal valley in South Tyrol, Italy. Two weeks of hands-on #NMR and #MRI with 12 excellent students and @Bucherlab.

Last day of our summer school in Sarntal in South Tyrol with hands-on NMR experiments. It was a pleasure for Dominik to work with 12 motivated students in the Alps with a benchtop NMR device to probe water, healthcare, and food samples. @magritek @HagnLab ferienakademie.de/en/home-2/

Our recent work on the mechanistic basis of Bcl2 protein inhibition at the #mitochondria which governs #apoptosis, just published in @CellReports Big thanks to Kira Leitl and Laura Sperl and @TU_Muenchen @HelmholtzMunich for support. doi.org/10.1016/j.celr…

Check out our new paper on using intein ligation for segmental isotope labeling of integral #membrane #proteins to boost #nmr studies, just published in @J_A_C_S. Thanks to Melina Daniilidis and the @TU_Muenchen and @HelmholtzMunich crew. Great job, folks! pubs.acs.org/doi/10.1021/ja…

BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

The Nobel Prize in Physiology or Medicine has been awarded to biochemist Katalin Karikó and immunologist Drew Weissman for discoveries that enabled the development of mRNA vaccines against COVID-19. go.nature.com/3tlfbuS

BNMRZ Symposium on Future Perspectives of Biomolecular NMR (1.2 GHz NMR Symposium) TUM Institute for Advanced Study and Bavarian NMR Center, Garching, Friday, October 13, 2023. Free to attend, registration is required bnmrz.org/NMR_symposium_… #NMRevents #NMRchat #NMR

Günsel et al. unravel the properties of OEP21, a channel in the chloroplast outer envelope, and show that it utilizes a promiscuous mechanism to control the passage of substrates. @HagnLab, @TU_Muenchen, @HelmholtzMunich, @LMU_Muenchen nature.com/articles/s4159…

Obituary: Harald zur Hausen, virologist who linked viruses to cancer (1936–2023) go.nature.com/471YAvN

Researchers investigated a new approach to optimize #photosynthesis in order to improve plants' ability to utilize sunlight, which could lead to an increase in #CropProductivity: go.tum.de/250425 🌾 #PlantScience #SustainableAgriculture #chloroplasts @HagnLab 📷A.Eckert

Join the #QuantumDays at the Deutsches Museum from May 19-21 where Steffen Glaser, our professor of #OrganicChemistry, and his team will demonstrate the basics of #QuantumInformationProcessing.

📝#PaperAlert: 💡A team of researchers led by Prof Franz Hagn at #HelmholtzMunich unravels the structural & functional properties of the #chloroplast outer envelope protein OEP21. 👉Read more about the channel #protein #structure resolved by #NMR 🔗t1p.de/btgi4

@MatthewEddyLab @JStructBiol @dfg_public @TU_Muenchen @HelmholtzMunich Thanks. We (and the community) are aware that you used uniformly labeled A2AAR. However, since you specifically analysed Gly and Trp resonances we cited your paper when mentioning amino acid selective studies. Apologies for this inaccuracy.

@HagnLab @JStructBiol @dfg_public @TU_Muenchen @HelmholtzMunich This is interesting work. And certainly nice spectra. The description of our earlier study with A2AAR, however, is not correct. The NMR data we published referenced here (Eddy et al. Cell 2018) was with a uniformly labeled receptor, not amino acid-specifically labeled.

Check out our new paper on high-resolution #NMR studies of the #GPCR neurotensin receptor just published in @JStructBiol and supported by @dfg_public @TU_Muenchen @HelmholtzMunich. authors.elsevier.com/a/1h2W43kGCFJk8

now with an intact URL: authors.elsevier.com/a/1h2W43kGCFJk…