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(1/2) How is epigenetic memory maintained across generations? 🧬 Our latest study reveals the role of SET-24, a SET domain-containing protein in C. elegans, in preserving germline integrity and small RNA-driven epigenetic silencing. Read more in our preprint!!

Just in case anyone is still here, check our latest preprint, right on time before the holiday season. We explored how transposable elements (TEs) diversify eukaryotic proteomes and found a cool case in nematode F-box genes. biorxiv.org/content/10.110… Short 🧵 with highlights.

How does AlphaFold3 predict the structures of proteins, DNA/RNA, ligands and other biomolecules? I did a deep dive into protein folding, how AlphaFold works and the new model. Here’s what I learned: (resource in thread)

@jeremycorbyn I would vote for you for PM. You are the most genuine politician standing on any ballot on the 4th.

I am standing as an independent candidate for the people of Islington North. As your MP, I will continue to be an independent voice for equality, democracy and peace. Please join our campaign at votecorbyn.com. Let's prove that when we come together, we can win.

$ENVX …. 👀 This was a well done spaces. I didn’t expect to speak but appreciated being invited to share my thoughts. I shared a number of insights in addition to providing a detailed overview of my thesis. @EnovixBatteries

@ge_parada @ericmiskalab @omerz213 @ericmiska @CRANberriesFeed @RNAStructureBot Thank you! Next time you are in town let me know. Would be great to catch up with all the new science 👍

@Jon_LP @ericmiskalab @omerz213 @ericmiska @CRANberriesFeed @RNAStructureBot It looks awesome! Congrats 🎉

rnaCrosslinkOO is out in @OUPBioinfo! doi.org/10.1093/bioinf… An easy to use @_R_Foundation package designed to analyse RNA cross-linking data. Raw reads to comparison of predicted structures. Data is available so please check out your favourite RNA. 1/3

As usual this is team effort! A huge thanks to everyone in @ericmiskalab. The authors - @Jon_LP, @omerz213, @ericmiska, Malte Pickert and Andrew Lim. See what it can do 🤗 @CRANberriesFeed @RNAStructureBot #RNA #RNAStructure 3/3

We show experimental evidence for in silica predictions of EEF1A1P5. As well as benchmarking against the 18S rRNA. 2/3

🚨New preprint alert!!🚨 I am delighted to share my first postdoc research paper on the interaction between transposable elements (TEs) and piRNAs in African cichlid fishes 🐠🐠 Link here: biorxiv.org/content/10.110… Find the highlights in 🧵

So excited to bring my contemplations on #lncRNA role in #lungcancer and #lungdevelopment to #RNAUK2024 🤩🤩 Thank you for the opportunity!

@Mucus_Man Hello there, I would go back and have a look at the raw counts. From the volcano plot, the plot of TPM counts does not look right

Dear computational biologists/statisticians, I'm have a DESeq2 trust crisis and I hope someone can explain this to me: I ran DESeq2 on an RNAseq and got this volcano plot with a fantastic candidate gene (circled). A dream come true, right? /1

Great science and the location isn’t so bad. #KSRNAMOD24

Great start to #KSRNAMod24 Keystone RNA modification meeting in amazing Banff 🏔️😎 #RNA #Epitranscriptomics

The journey has begun, bring on the #RNA! @KeystoneSymp #KSRNAMOD24

Very happy that my first contribution to the cichlid community is out🐠🐟🐠. This review was the outcome of the Genome editing workshop at @Cichlid2022. We hope it will be useful for the community! Check @_Bethan_Clark's thread for details.

@r0zetta @fchollet This is such good food

Is GPT-4 intelligent enough to solve ARC (github.com/fchollet/ARC)- a collection of intelligence tests devised by @fchollet? I ran a few quick experiments to check. #gpt4 #gpt #ai #ml

@YiliangDing @danny_incarnato @univgroningen @JohnInnesCentre @NorwichResearch @biouea @EarlhamInst @alperakay_ @WHaerty Online also?

The superstar in the RNA structure field, Danny @danny_incarnato will give the new year's first seminar of the Norwich RNA Club. @univgroningen @JohnInnesCentre @NorwichResearch @biouea @EarlhamInst @alperakay_ @WHaerty

@ericmiska @migueldvalmeida @ericmiskalab @CamBiochem @CambridgeTeClub - indeed! Very cool talk @migueldvalmeida

@migueldvalmeida @ericmiskalab @CamBiochem speaking at the Dark Matter of the Genome session about his work on TEs in cichlids 🐟🐠🐡