Konermann Lab

Can enzymes retain catalytic activity in the gas phase? Using tandem MS, molecular dynamics simulations, and enzyme variants courtesy of the @VahidiLab, Kirsty (@kirstynyk) uncovers new insight towards this question. Now published in JACS (@J_A_C_S)! pubs.acs.org/doi/10.1021/ja…

Catalytic Activity of Electrosprayed Enzyme Ions in the Gas Phase | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

In our newest paper, Evelyn takes a close look at thermal unfolding experiments to see if they're really as reversible as we assume. SPOILERS: they're not, but we've established some strategies to mitigate this problematic irreversible thermal unfolding. pubs.acs.org/doi/10.1021/ac…

In our quest to fully understand the ESI process, Lars developed an algorithm to determine potentials and electric fields associated with an ESI source. This strategy eliminates the need for differential calculus to design realistic ESI emitters using MD. pubs.acs.org/doi/10.1021/ja…

If you're in Baltimore for #ASMS2025 make sure to catch Lars' talk (@KonermannLars) at 10:10 in room 309! There's also Evelyn's poster today (WP 609) and @kirstynyk's talk tomorrow at 3:10 in Ballroom IV to watch out for!

From Taylor cone formation to gaseous ions, the complete ESI process has been modeled with continuous solution flow for the first time! Our very own @mdolatkh has just published her MD simulations in our newest paper. pubs.acs.org/doi/full/10.10…

We have a last minute holiday gift from (and also to) the Konermann Lab! @pabloscrosati and Evelyn have married HPLC and MD using umbrella sampling to determine the free energy of peptide-stationary phase binding and correctly predict elution order! pubs.acs.org/doi/10.1021/ac…

A huge congratulations to Kirsty Ng @kirstynyk for receiving the 2024 G. Michael and Joan Bancroft Research Award and presenting her outstanding research! This award celebrates the research excellence of a third year PhD student @westernuchem

"Can we get serious [about HDX-MS] now?" Lars and Pablo (@pabloscrosati) address the limitations of HDX-MS's ability to provide truly quantitative information on protein dynamics and share some strategies for complementing HDX data with simulation tools. doi.org/10.1016/j.mcpr…

Another great talk by Prof. Lars Konermann at the CFABS Toronto Post-ASMS Symposium! If you're interested in learning more about these serine magic number clusters, you can check them out here😉 pubs.acs.org/doi/10.1021/ja…

Credit also goes to Sanvid Mehta in our lab, who wrote an important part of the code used for the MD simulations of serine cluster formation!

Ever wondered how serine octomers form to dominate spectra during ESI? Vida (@AlinezhadVida) and Kirsty (@kirstynyk) explain it all in the Konermann Lab's newest paper! We've got experiments *and* MD simulations in here so there's something for everyone! pubs.acs.org/doi/10.1021/ja…

Newest paper from the lab: @HanifiKasra examines ESI droplet simulation parameterization and proposes some new "best practices" for modeling ESI droplets with MD. pubs.acs.org/doi/10.1021/ac…

Glad to see old friends (and labmates) here for convocation. Great to hear about what @heisenberg2T1 and @AlinezhadVida are doing now and where they're heading next.

@MethylTROSY @pabloscrosati @ProteinSociety This is the new admin in charge, Pablo was quick to transfer the account to someone else.

@KonermannLab @pabloscrosati @ProteinSociety The question is, is this Pablo congratulating himself 👀 or is there a new admin in charge? (But also, congrats!)

Congratulations to @pabloscrosati for winning a CSC travel award to present his poster (The Stressful Life of Cytochrome c) at @ProteinSociety 's 38th annual symposium. This is the Konermann Lab' s third year in a row winning this award🥳🥳

The Konermann Lab ASMS reunion was tons of fun this year! Always great to talk shop (and Kevin Costner) with Konermann students past and present!

Always a joy to see young scientists fall in love with mass spectrometry!!! (our own young scientists now feel prompted to flex their #ASMS2024 awards too👀)

The Konermann Lab is at #ASMS2024! You may have missed our two posters, but you can still catch Lars' oral presentation tomorrow morning in room 207ABC! He'll be talking about serine octamer cluster formation (a very interesting story), and you won't want to miss it!

Huge congratulations to Vida (@AlinezhadVida), who successfully defended her Master's thesis on Monday! She studied the formation mechanism of serine magic number clusters during ESI! That drink from the Goblet of Knowledge was well earned.