Sakamoto Lab

After 5 years here, we are phasing out & moving to @bluesky for good. Our lab profile will still be here but we will not be active anymore. Thank you to all our followers & hope to connect with you on the other platform.

"Isolation of functional lysosomes from skeletal muscle" is now in press. Check it oput at: journals.physiology.org/doi/epdf/10.11…

Special thanks to Wageningen University for bringing us today's #ArticleinPress #OpenAccess! Six-hour #hypoxia induced #protein degradation in M. gastrocnemius of 24-day-old mice by activating FOXO1 and suppressing AKT-mTORC1 (Jingyi Song et al.): ow.ly/jz0v50VssYN

A human brain map of mitochondrial respiratory capacity and diversity | Nature nature.com/articles/s4158…

Wondered how #adipocyte #fat release #lipid via #lipolysis in #fasting, cold exposure? Multi-year @Razanilab effort in @jclinicalinvest by postdoc maven @yushengyeh identifies #lysosome lipolysis (LAL) as major way on par with known cytosolic route (ATGL) jci.org/articles/view/…

Linoleic acid is the most abundant polyunsaturated fatty acid in the Western-style diet and has been implicated in promoting inflammation and cancer. In Science, researchers report a mechanism by which linoleic acid can activate the mTORC1 protein kinase, which coordinates growth and nutrient signals. Learn more: scim.ag/4bxxLSN #SciencePerspective

Finally the tides are starting to turn!! Cancer isn’t all about DNA mutations, nor even mRNA levels. We launched SyzOnc to map the proteins underlying deadly cancers that are not DNA-driven. journals.plos.org/plosbiology/ar…

A bacterium makes a molecule that kills drug-resistant fungi in an unusual way — by targeting various phospholipid molecules in membranes. go.nature.com/3FHmgwb

New! Online now: Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism dlvr.it/TJd12Y

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research | Nature Metabolism ⁦@NatMetabolism⁩ Great collaboration led by ⁦@SatchinPanda⁩ and team! nature.com/articles/s4225…

First time doing a X-tweetorial on our manuscript, be kind ! Our latest work in Nature Metabolism uncovers a striking role for glycogen accumulation in lung adenocarcinoma (LUAD) using spatial metabolomics & MALDI imaging. A thread 🧵 (1/)

Managing insulin resistance: the forgotten pathophysiological component of type 2 #diabetes thelancet.com/journals/landi… #T2D

New! Online now: Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling dlvr.it/TJX2Zl

We are lucky to have incredible #diversity in our group where we learn about new #cultures, #languages, #traditions & most importantly, food! We did a potluck with traditional cuisines around the world & these scientists are not only brilliant, they have mad culinary skills too!

The Sakamoto group members in action on Metabolism Day #MD25 , a 1 day international conference about energy control and metabolism organized by @Metabolcenter , now in its 7th successful year!

We have a postdoc position available in our team to undertake a UKRI-funded project to develop a new cultured skeletal muscle model for studying glc metabolism and insulin action. jobs.cam.ac.uk/job/50597/ @IMS_MRL Please RT. Please email if interested.

Happy to share the final version of our new paper published in @NatureComms describing a novel inducible, tissue specific #PolG mutation mouse model, that provides interesting insights into muscle specific #mitochondria induced stress responses nature.com/articles/s4146…

adiposetissue.org: A knowledge portal integrating clinical and experimental data from human adipose tissue dlvr.it/TJRBCj

Lab Sakamoto members at the Metabolism Day #MD25 @Metabolcenter Posters were presented by postdocs Joy & Jordana and by PhD students Maria, Hongling, Conchita & research assistant Costanza. #AMPK #TFEB #SIK bsky.app/profile/labsak…

Our group @Metabolcenter is now driven by an all women workforce (barring Kei), & we are incredibly fortunate to have these (multi)talented, hard working & generous women who support & elevate each other every day! Happy International Women's Day! #WomensDay2025