Paul Macklin

We're so honored to receive the 2019 PLoS Computation Biology Research Prize in Public Impact. We wrote PhysiCell to empower modelers to do new and bigger science. I hope this prizes lets us reach and help even more. @CompCancer @rheiland @IUBloomington @IUSICE @ara_anderson

@FritzdKat @McDonalds That was fast! Amazed you got in to even see that result! I was at error 429 even at 10:59 am

@MathCancer @McDonalds Popped up for a second saying sold out and dropped again

Yep, this is pretty much how I figured the 11 am caviar promo would turn out at @McDonalds

Background: usatoday.com/story/money/fo… (Same error on Xfinity and Verizon 5G, for the record.)

@Magnetodawn Happy 2026 to you! Please LMK if you do find yourself on BlueSky. (I'm there under same username.)

Friends, I have been focusing my thoughts & efforts elsewhere, and am migrating away from X. Feel free to telephone or email me, if I may be of assistance. Please enjoy a wonderful 2026! Kind regards, Dawn Marie Mueller

Waited in a 90-minute line in the rain to get one last Sprinkles Cupcake before all of the stores shut down forever. Corporate America delivering one last shitty moment to ring out a very shitty year. Fuck 2025 and fuck private equity.

Thrilled to see our project on the cover of this week's @ScienceMagazine. Incredibly fun and rewarding collab with the public, @eliz_aguilar2 @JuncoWren @imillercrews @MathCancer

Epic indeed, @JoshuaABull !

This week in Math Onco 345: Darwinian evolution, digital twins, multiscale modeling, and antifragility Art: @MathCancer & Heber L Rocha 😎💯

In a serious case of a weirdly small world, I ran into @Seirin_Lab at @OxUniMaths in the visitor office. What a joy!

@FabianSpill Thanks, Fabian! and was great to see you at SMB!!!

Congrats to this paper, quite a lot in there from agent based modelling to spatial transcriptomics, utilising a new grammar

@SKabrajiMD @JKTGFoundation @BCRFcure @theNCI @NIH @PhysiCell And we're just getting started! We are now working to make it easier to load, export, share, and recombine models written in the grammar, and next-generation extensions of the language. Also working with other open source leaders to support the grammar for model exchange

@SKabrajiMD @JKTGFoundation @BCRFcure @theNCI @NIH Thank you! Yes, the grammar is already fully incorporated in @PhysiCell, and you can try it yourself with web-based PhysiCell Studio. Please do!! I suggest a recent short course we taught last week that gives a taste! :-) github.com/physicell-trai…

They were able to show how cancer-fibroblast interactions can drive malignant transformation (EMT), but in some cases, these interactions can also trap cancer cells to prevent spread. 10/n

And we're beyond grateful for early support by the @JKTGFoundation (and even earlier by @BCRFcure) and @theNCI and @NIH. Without early support for basic sciences, we would never have been in the position to create this work today! 17/17

It was a great honor to work with this team. We have accomplished something beautiful together we could never have done on our own. It is an honor to count them as colleagues and friends! 16/n

They were able to use the grammar to entirely encode the complex model (again, no hand-written code!) including complex relationships between ECM density and cell migration that were revealed by experiments at Johns Hopkins. 9/n

Digging deeper Jeanette Johns and Daniel Bergman led work with Elana Fertig and a wide network of collaborators (including Laura Wood, Andy Ewald, Jude Phillips and others) to create a model of pancreatic cancer (PDAC) 7/n