Mathieu G

4% of centenarians die from cancer. Before age 80, it's 25-40%. The people who live the longest are barely dying of the disease everyone fears most. A new @NatRevImmunol review found their immune cells tell the story. NK cells in centenarians keep young transcriptional signatures. RUNX3 stays on. Cytotoxicity stays high. Both normally fade by 70. Their bodies handle inflammation differently too. Same chronic inflammation as any aging person, but the NLRP3 inflammasome, the trigger for inflammatory disease, is suppressed. Mice without NLRP3 live 34% longer (males). 722,000 centenarians exist today. The immune pathways they've preserved are the same ones in active aging-disease trials. Survivorship bias is the obvious objection. The NLRP3 data from mouse models doesn't care.

@LP_LaPresse J'espère!

Accès à un médecin de famille | « C’est encore plus difficile pour les nouveaux arrivants » lapresse.ca/actualites/san…

The most fascinating part of the Odyssey to me is the Cretan Lie. When you think of the Odyssey, the first thing you picture is probably Odysseus’s run-ins with famous monsters. The Cyclopes, the Sirens, Scylla, Charybdis, etc. But there’s a reading of the Odyssey in which none of these events took place, and a far more historically intriguing sequence of events emerges. For one, we don’t actually ‘see’ the run-ins with the monsters take place in the poem. Instead, these details all come from Odysseus’s own narration to the Phaeacians. They’re part of the story he tells them of his travels to convince them to charter a fleet to send him back home to Ithaca. The problem is, Odysseus is a liar. He lies constantly, any time he pops up in Greek mythology. In fact, in the Odyssey he tells many different people many different versions of what he did after Troy. And why would he tell the Phaeacians the truth? He wouldn’t, of course. He would tell them whatever he thought they wanted to hear. To me, the most intriguing version of events he tells is to his loyal swine herd. While still in disguise pretending to be a Cretan, Odysseus says that after the sacking of Troy, he led his men on an expedition against the Egyptians. But his expedition failed. His men were all killed or enslaved by the Egyptians. But he threw himself at the Pharaoh’s feet and begged for mercy. He received it, and spent 7 years in Egypt, where he amassed great riches, before being tricked and nearly sold into slavery in Phoenicia, but then surviving a shipwreck and making his way back to Ithaca. We know the Trojan War would’ve taken place during the same period that the Sea People were sacking their way down the coast of Anatolia (where Troy was) to Egypt, where Ramses III ultimately defeats them. This matches up perfectly with Odysseus’s ‘lie.’ I like to think that Odysseus saved the most honest version of his travels for his most loyal servant (though still cloaked in a lie, as Odysseus’s stories always are). And that Homer has preserved more about the Bronze Age collapse than we’ve ever given him credit for.

We warned scientists not to squander people’s trust. Investigate the lab leak Don’t overclaim for vaccines Don’t demand lockdowns Don’t worship models Don’t be dogmatic Encourage debate They have only themselves to blame.

This meme is going to turn into reality

Aged mice received ONE peptide — FOXO4-DRI — for 3 weeks. Fur grew back. Kidneys healed. Fitness returned. The aging REVERSED. (PMID: 28340339 — published in Cell) Right now there are MILLIONS of dead cells rotting inside your body. They can’t divide. They can’t repair. They REFUSE to die. They just sit there POISONING every tissue around them. Scientists call them zombie cells. The single biggest driver of aging ever discovered. → joints rotting with inflammation → skin collapsing as collagen disappears → wounds taking weeks instead of days → testosterone crashing year after year → energy vanishing no matter what you try Your doctor calls this “getting older.” It’s not. FOXO4-DRI is a synthetic peptide your body can’t break down. It does ONE thing. Zombie cells survive by TRAPPING p53 — your body’s kill switch. FOXO4-DRI frees it. The zombie cell self-destructs. Healthy cells don’t use this trick. Untouched. Every day you wait, more zombie cells accumulate. More tissue dies. Your body has a self-destruct button for broken cells. Age jammed it. FOXO4-DRI unjams it. The studies are below.

@LP_LaPresse Il n'y a pas assez de Blancs pour faire vivre tout le monde

Afrique du Sud | Flambée de violence contre les migrants lapresse.ca/international/…

Remind myself of the role reversal often.

A ten strike law preventing people from leaving prison after that many violent crime convictions would reduce period violent crime by 20% Five strikes would cut violent crime by 40% Three strikes would halve violent crime Two strikes would remove ~two-thirds of violent crime

Thank you Germany 🇩🇪and Britain 🇬🇧 for sacrificing your economies to save the planet. China appreciates you exporting your manufacturing to provide jobs for their citizens.

- Ethiopian comes on a study visa - A "minor traffic infraction" in Calgary sends him into road rage - Pulls a loaded Glock on the other driver - Probably won't be deported though because Ethiopia is dangerous - So instead Ethiopian criminals can stay and make Canada dangerous?

The polls probably aren't wrong. Boomers, women, and gimmigrants love the Liberal Party, because it transfers wealth and opportunity to them at the expense of the young white Canadian men who actually generate every cent of value in the country. It's a coalition of parasites and the parasites are absolutely in control. That's half the story. The other half is that the Conservative Party is as inspiring as soggy bread. It stands for nothing. Its remaining MPs (the ones who haven't crossed the floor to the Liberal Party) are a foul mixture of cynical opportunists, ethnic grifters, and spineless moral cowards. Its sole purpose is to suck up all of the oxygen in the space for organized political opposition, thereby preventing any effective opposition to the Laurentian program of systematic national suicide.

@globeandmail Just replace them with AI already!

Telus using AI to alter the accents of customer-service agents theglobeandmail.com/business/artic…

"We know you hate this, but we hate you, so we're doing it anyway."

THIS IS CRUEL AND UNACCEPTABLE IN A SOCIETY THAT CLAIMS TO BE CIVILIZED! SHAME ON THE POILIEVRE’S FAKE CONSERVATIVES WHO REMAIN SILENT IN THE FACE OF THESE LATE-TERM ABORTIONS AND APPROVE OF THESE MURDERS! The PPC welcomes a debate on abortion. We must stop listening to hysterical feminists who have hijacked this issue for too long. The People’s Party believes it is time for Canada to join the civilized world by enacting reasonable restrictions on abortion that balance the rights of the mother with the protection of unborn life. A People's Party government will: -Foster a National Debate on Abortion Break the taboo surrounding abortion and encourage an open, respectful, and fact-based discussion on this issue. Challenge other political parties to explain why they believe killing a healthy and viable unborn child is morally acceptable and should remain legal. -Align Canada with International Standards on Abortion Introduce the Protection of Preborn Children Act to bring Canada in line with the laws of other civilized countries, where abortion is gradually restricted after the first trimester and late-term abortions are prohibited except in exceptional circumstances. PPC MPs will be free to vote on the issue of abortion according to their conscience. Read our policy on abortion here 👇 peoplespartyofcanada.ca/issues/abortion

Today I learned that Corks🍾come from the Cork Oak tree in the Mediterranean. They peel the bark like this (not harmful to the tree) and the bark regenerates and is ready for harvest every 9+ years. The trees live 200+ years but are only harvested starting at 25 years old.

being wrong is the best way to get cited a lot

La confirmation par la génétique d'aujourd'hui de la conquête Yamnaya il y a 5 000 ans est l'un des plus beaux hommages aux grands linguistes et mythologues. Entre 1800 et 1950, ils avaient deviné cet événement par l'analyse de langues parlées entre l'Inde et l'Irlande ainsi que par l'analyse des mythes de l'Inde à l'Europe. Les généticiens (bravo à eux !) confirment aujourd'hui une hypothèse née du rapprochement aussi obscurs que la grammaire entre Inde et Irlande ou entre l'histoire romaine mythifiée et les épopées védiques.

No matter the poll, Bukele's approval rating is nearly always over 90%. In the last three polls, it's 93%, 93%, and 94%. I've never seen anything like this. We need to study this regime. The international community has massively underestimated the importance of public order.

🇨🇦's "sovereign wealth fund" isn't a fund but "another borrowing vehicle" for fiscal plans. This isn't an investment in our future. They're hiding a larger deficit spending. This is financial engineering one would expect from a penny stock fraud, not gov. via BMO.