Jane Shaw

#Fig1" target="_blank" rel="nofollow noopener">nature.com/articles/s4158… I love this. I love that people are thinking seriously about this, but mostly I just love the name.

@YCGaryLee @philchestorg @APSRapsr @uwanews @UWAresearch @tsanz_thoracic @NCARD_research @Resp_Health @WHOPhilippines @pccp_lunginfexn @EdithCowanUni @NMHS_WA @ARNS_UK Luckily the sunrise symposiums don’t actually start at sunrise!

Arriving late night into Manila for the Philippines College of Chest Physicians 44th Convention. Looking forward to an informative 3 day meeting. @philchestorg @APSRapsr @uwanews @UWAresearch @tsanz_thoracic @NCARD_research @Resp_Health @WHOPhilippines

🟩#TB pleural effusion: Diagnosis + Rx; a topic relevant to all pulmonologists/general physicians. @OnlyFreshAir will discuss on Feb 5 at THE AUSTRALASIAN #PLEURAL SEMINARS. Join us! @PleuralPOCUS @EuroRespSoc @AAB_IP @tsanz_thoracic @ARNS_UK @TBNTuberculosis @CDC_TB @PulmPEEPs

What a journey. Thanks @SUhealthsci

theconversation.com/the-peer-revie… Some interesting things to consider. I have to agree that peer review does not always guarantee quality…

@YCGaryLee @wabipconnect @tsanz_thoracic @BGrandRounds @UKPleura @pleuralwales @AAB_IP @CHESTOncology @BRONCHOLOGISTS @phlegmfighter @PulmPEEPs @udit_chaddha Subtle

Memorable question @wabipconnect #Bali2024 #Pleural Session: Q&A with me + Prof Astoul (pleuroscopy guru): Audience: Prof Astoul what's your best strategy for intercostal hemorrhage from pleuroscopy bx? Prof: Don't know. Never had one; I'm always careful. Ask Gary Lee... 🤣🤔

#MyOAarticle "Optimising the yield from bronchoalveolar lavage on human participants in infectious disease immunology research" received 905 downloads since its publication. Access the article here: nature.com/articles/s4159…

@Sutherland_TB Sorry Jayne, how frustrating

Update - now 3 of my study clinicians are unable to go to the Union meeting in Paris this week. 2 with oral presentations. So disappointing for all concerned. Not to mention expensive and time consuming since applications could only be made in Dakar, a 10h drive from here...

This deserves many many reposts. Affordable Cystic Fibrosis (CF) Transmembrane Conductance Regulator Modulator Drugs for CF: All CF Lives Worldwide Matter! | American Journal of Respiratory and Critical Care Medicine atsjournals.org/doi/full/10.11…

I mean, I’ve aged about 30 years in the last 2 hours, but totally worth it

Clinical characteristics of chylothorax: results from the International Collaborative Effusion database openres.ersjournals.com/content/9/5/00…

What a player

@AGLoxton @Springboks Lacklustre for the win?

Toddler's T cells are taught in muco-school | Science Immunology science.org/doi/full/10.11…

Traditional cultures for diagnosing infection are limited by sensitivity & can require days to give results. The CHEST #Sepsis Resources Steering Committee outlines newer molecular methods that may be able to identify pathogens & drug resistance sooner: hubs.la/Q01YnMv10

Join us on Aug 2 for the Interventional Pulmonology Update Series Symposium! Presented by The Institute for Respiratory Health & Sir Charles Gairdner Hospital Interventional Bronchoscopy Unit. Don't miss out, READ MORE at wabip.com/events/601-lun…

@AGLoxton The real question is should you message that one person who is clearly not paying attention to the meeting and still hanging around after everyone else is logged off… I mean, do we need another 5 hour long meeting recording?

Is there an unofficial cut-off time for how long after the Teams #meeting ended people can still respond and type: thanks all/ bye, good meeting? Feel like they missed their opportunity 5 minutes ago. #letitgo #Teams #etiquette

Low airway surface pH impairs antimicrobial host defence and worsens airway inflammation. A novel, inhaled, alkaline buffer medication, Optate, raises airway pH and inhibits RSV infection in primary human airway epithelial cells in a dose-dependent manner. bit.ly/4138MAM

A mind-blowing paper has come out today in @Nature In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (science.org/doi/10.1126/sc…). Today, a group of scientists from Indiana University reports how that minimal genome evolved over 2000 generations in comparison to the non-minimal genome. The authors found that even when you reduce a bacterial genome to its absolute minimum where every nucleotide matters, the genome undergoes mutational events generation after generation as much as the non-minimal genome. One simply cannot stop the evolution. Just over 300 days of evolution (equivalent to 40,000 years in humans) the minimal cell has gained everything it lacked in fitness on day one in comparison to the non-minimal cell. When comparing the evolved traits between the minimal and non-minimal cells, the scientists found something striking. The evolutionary process increased the cell size of non-minimal cells but not that of the minimal cell. But that is not the striking part. The scientists were able to identify the key mutation that resulted in cell size evolution. And it turned out that the mutation that helped the non-minimal cells to grow bigger is the same that helped the minimal cells to stay smaller. Growing bigger had a survival advantage for non-minimal cells and not growing bigger had a survival advantage for minimal cells. So, the mutation had a context-dependent effect. This just demonstrates that the evolutionary effects on traits have no absolute direction. All that matter is what is beneficial for the organism's survival. The conclusion of the paper is metaphorically a quote from the Jurassic Park movie: “Listen, if there’s one thing the history of evolution has taught us is that life will not be contained. Life breaks free. It expands to new territories, and it crashes through barriers painfully, maybe even dangerously, but . . . life finds a way". (scienmag.com/artificial-cel…) nature.com/articles/s4158…

Well this is news to me