Psychoradiology

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Psychoradiology@PSYRAD2·6h

🚨New research investigating sex-specific aberrant brain activity in LLD finds: ·Significant interaction effects found for ALFF (paracentral lobule), ReHo (superior temporal gyrus), and static FC. ·ReHo and sFC correlated with weight... Link: doi.org/10.1093/psyrad… #Depression

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Psychoradiology@PSYRAD2·1d

🔹Analysis: Used correlation and moderation analyses to examine if sex moderates associations between brain activity, cognitive impairment, and depressive symptoms. Link: doi.org/10.1093/psyrad…

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Psychoradiology@PSYRAD2·1d

x.com/PSYRAD2/status… Study Design👇: 🔹75 LLD patients and 164 HCs. 🔹Compared static and dynamic metrics of ALFF, ReHo, and functional connectivity (FC). 🔹Analyzed 4 groups (LLD-female, LLD-male, HC-female, and HC-male). #LateLifeDepression #SexDifference #rsfMRI

📢New study out in @Psychoradiology (Zheng et al., 2026)! Scientists reveal how sex differences in ALFF, ReHo, and FC are related to clinical symptoms and cognitive impairment in patients with late-life depression. 👉Learn more:doi.org/10.1093/psyrad… #Depression #SexDifference

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Psychoradiology@PSYRAD2·1d

x.com/PSYRAD2/status… - Why do men and women experience Late-Life Depression differently? 🧠⚧️ - This study investigates sex-specific aberrant brain activity to uncover the neural roots of these disparities.🔗: doi.org/10.1093/psyrad… #Depression #Neuroscience #BrainFunction

📢New study out in @Psychoradiology (Zheng et al., 2026)! Scientists reveal how sex differences in ALFF, ReHo, and FC are related to clinical symptoms and cognitive impairment in patients with late-life depression. 👉Learn more:doi.org/10.1093/psyrad… #Depression #SexDifference

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Psychoradiology@PSYRAD2·2d

📢New study out in @Psychoradiology (Zheng et al., 2026)! Scientists reveal how sex differences in ALFF, ReHo, and FC are related to clinical symptoms and cognitive impairment in patients with late-life depression. 👉Learn more:doi.org/10.1093/psyrad… #Depression #SexDifference

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Psychoradiology@PSYRAD2·5d

Suicide has profound global effects, underscoring the urgent need for early detection.🧠 This comprehensive meta-analysis by Qianlan Yin et al. investigates event-related potentials (ERPs) as a tool for identifying suicide risk. 🔗:doi.org/10.1093/psyrad… #SuicidePrevention #ERPs

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Psychoradiology@PSYRAD2·6d

x.com/PSYRAD2/status… Final Takeaway: ✅Changes in causal connections between specific brain regions significantly contribute to neurological deficits in anti-LGI1 encephalitis. ✅Hippocampal-striatal inhibitory connectivity may serve as a biomarker for personalized diagnosis.

How does LGI1 antibody encephalitis disrupt the brain's causal network? 🧠🚨 This spectral dynamic causal modeling study by Qiao et al. reveals the specific cause and underlying mechanisms of LGI1 encephalitis. 🔗: doi.org/10.1093/psyrad… #brain #Encephalitis #LGI1 #BrainNetwork

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Psychoradiology@PSYRAD2·6d

- Clinical Link: Hippo-STG inhibitory EC correlated inversely with symptom severity and positively with cognitive performance.#brain #hippocampus #EffectiveConnectivity

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Psychoradiology@PSYRAD2·6d

x.com/PSYRAD2/status… Key findings reveal distinct effective connectivity (EC) patterns:📉✨ - Circuit: Inhibitory EC from hippocampus to STG; excitatory EC in reverse. - PCC: Patients showed reduced inhibitory self-connections in the posterior cingulate cortex #LGI1 #Neurology

How does LGI1 antibody encephalitis disrupt the brain's causal network? 🧠🚨 This spectral dynamic causal modeling study by Qiao et al. reveals the specific cause and underlying mechanisms of LGI1 encephalitis. 🔗: doi.org/10.1093/psyrad… #brain #Encephalitis #LGI1 #BrainNetwork

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🔗: doi.org/10.1093/psyrad… #EffectiveConnectivity #fMRI #SpectralDynamicCausalModeling

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Psychoradiology@PSYRAD2·6d

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Psychoradiology@PSYRAD2·6d

Study Design: 🔹27 patients with anti-LGI1 encephalitis vs 28 HC. 🔹ALFF analysis used to identify altered brain regions. 🔹Spectral dynamic causal modeling to assess effective connectivity (EC). 🔹Analysis of EC strength vs clinical severity & cognitive function.#fMRI #Neurology

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Psychoradiology@PSYRAD2·17 Mar

x.com/PSYRAD2/status… The specific cause and underlying mechanisms of LGI1 antibody encephalitis remain unclear.🔍 The study aims to uncover the pathological insights of this disorder by examining the causal connections and effective connectivity between altered brain regions.

How does LGI1 antibody encephalitis disrupt the brain's causal network? 🧠🚨 This spectral dynamic causal modeling study by Qiao et al. reveals the specific cause and underlying mechanisms of LGI1 encephalitis. 🔗: doi.org/10.1093/psyrad… #brain #Encephalitis #LGI1 #BrainNetwork

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Psychoradiology@PSYRAD2·16 Mar

How does LGI1 antibody encephalitis disrupt the brain's causal network? 🧠🚨 This spectral dynamic causal modeling study by Qiao et al. reveals the specific cause and underlying mechanisms of LGI1 encephalitis. 🔗: doi.org/10.1093/psyrad… #brain #Encephalitis #LGI1 #BrainNetwork

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Psychoradiology@PSYRAD2·12 Mar

🌟This commentary explores the potential of 7Li-MRI in Bipolar Disorder. By utilizing 7T high-field scanners and 7Li-CSI, researchers can now map brain lithium distribution in vivo to predict treatment response and enable patient stratification. 🔗:doi.org/10.1093/psyrad… #7T

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Psychoradiology@PSYRAD2·12 Mar

x.com/PSYRAD2/status… Final Takeaway:🧠🧩 ✅Establishing a novel molecular–neural pathway where DMN activity mediates the link between GDNF and rumination in MDD. ✅Highlights GDNF as a potential therapeutic target for depression. Follow #Psychoradiology for more!🔔#Depression

🚨New study alert in @Psychoradiology!🧠 How do peripheral GDNF levels influence the depressed brain? This study by Fennan Jia et al. reveals the relationships between glial cell line-derived neurotrophic factor, brain circuits, and clinical symptoms in depression.#MDD #fMRI #DMN

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Psychoradiology@PSYRAD2·11 Mar

🔹Mediation: Neural activity in the DMPFC subsystem mediated the relationship between GDNF levels and brooding rumination. 🔗: doi.org/10.1093/psyrad… #Depression #MDD #Neuroscience #fMRI #DMN #BrainNetwork

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Psychoradiology@PSYRAD2·11 Mar

x.com/PSYRAD2/status… Results: A new study reveals a novel mediation pathway in the depressed brain: 📉✨ 🔹Serum: MDD patients showed significantly reduced GDNF and IL-8 levels. 🔹DMN: Interaction effects in fALFF within both DMPFC and MTL subsystems.#Depression #fMRI #DMN

🚨New study alert in @Psychoradiology!🧠 How do peripheral GDNF levels influence the depressed brain? This study by Fennan Jia et al. reveals the relationships between glial cell line-derived neurotrophic factor, brain circuits, and clinical symptoms in depression.#MDD #fMRI #DMN

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Psychoradiology@PSYRAD2·11 Mar

x.com/PSYRAD2/status… Methods🔬📊: 🔹Sample: 33 MDD patients vs 33 HC. 🔹Task: fMRI during a sustained, active rumination task & RRS assessment. 🔹Imaging: fALFF and functional connectivity within DMN subsystems. 🔹Biomarkers: Quantified serum GDNF and inflammatory markers.#MDD

🚨New study alert in @Psychoradiology!🧠 How do peripheral GDNF levels influence the depressed brain? This study by Fennan Jia et al. reveals the relationships between glial cell line-derived neurotrophic factor, brain circuits, and clinical symptoms in depression.#MDD #fMRI #DMN

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Psychoradiology@PSYRAD2·10 Mar

x.com/PSYRAD2/status… Rumination is a pivotal psychopathological process in #MDD.🔍 Using a modified rumination paradigm, the study explored how neurotrophic factors and immune activation interact to mediate brain activity associated with depressive cognition.#Depression #brain

🚨New study alert in @Psychoradiology!🧠 How do peripheral GDNF levels influence the depressed brain? This study by Fennan Jia et al. reveals the relationships between glial cell line-derived neurotrophic factor, brain circuits, and clinical symptoms in depression.#MDD #fMRI #DMN

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