John Schimenti

A terrific body of work by postdoc Munisha Mumingjiang and grad student Rui Huang on the impact of genomic instability on trophoblast stem cells and placenta development. Years in the making. biorxiv.org/content/10.110…

@jaygirimd @epler_john @NIH @petegroen @djc795 @adnanalkhouli @PennCardiology @CMichaelGibson @PennLDI A few decades ago, I remember writing in a % of admin salaries (say, a Departmental staffer) on my grants (part of DC). I guess rule changes since then pushed those all into IDC.

@epler_john @NIH @petegroen @djc795 @adnanalkhouli @PennCardiology @CMichaelGibson @PennLDI Bureaucratic personnel costs are significant. Efforts at de-regulation could reduce these. Tradeoff is that medical research is an arena where the public appears to desire high levels of regulation, protection, auditing, privacy, etc.

🧵 Many “hot takes” about the reduction of @NIH indirect grant costs to 15%. Let’s lay out the facts about the university grant management process & accounting. And then use this to project likely short and longer term impacts of the policy.

A high throughput CRISPR perturbation screen identifies epigenetic regulators impacting primordial germ cell development biorxiv.org/content/10.110… We found that a histone deacetylase KD, and HDAC inhibitors (inc. a dietary supplement), impede PGCLC formation> somatic genes stay on

Scalable and Efficient Generation of Mouse Primordial Germ Cell-like Cells biorxiv.org/content/10.110… If you need a ton of PGCLCs and don't want to use expensive cytokines in the process, you may find this method useful.

@Cryptocito Thanks Cito for you great content! Been following you for a couple of years on YouTube, and as a result I too have focussed most of my Crupto interest on the Cosmos.

IT HAPPENED 🥹 THANK YOU for your support. THANK YOU for sharing my content. THANK YOU for absolutely everything. I will definitely need the weekend to fully process that because it's a crazy milestone achievement for me personally as Michael but also for me as Cryptocito. I decided to make Crypto my career path back in 2017 and it certainly has not been easy but I've just been grinding through non-stop and am grateful for everyone I've met along that journey, for everyone who works with me on the content side, Cosmoverse, Stakecito and everything around it. THANK YOU THANK YOU THANK YOU💙

1 y.o. grand-daughter figures out how to make every putt!

Our studies of why genetic variant pathogenicity prediction algorithms leave much to be desired: pnas.org/doi/10.1073/pn…

@ollie_rando @CorcesVictor There's a series of (dubious?) papers on "sperm mediated gene transfer." For example: Cell 1989 doi: 10.1016/0092-8674(89)90787-3. Wonder if fragments of epididymal DNA carried by sperm ever integrate into fertilized egg?

1/ Of course we didn't use DTT. It makes no sense to try to analyze the state of chromatin by first destroying it with DTT. You are contaminating the sperm with DNA from the epididymis by mincing the tissue, which we don't do.

academicjobsonline.org/ajo/jobs/22987 jcs92@cornell.edu (John Schimenti) pc242@cornell.edu (Paula Cohen)

Junior faculty positions at Cornell in reproduction!

RT @nyscf: Meet NYSCF – Druckenmiller Fellow @MominMunisa, #postdoc in the @Tcomplex lab @Cornell! Munisha studies the genetics behind #pla…

@adernburg @Tesla Maybe your card? Possibly the 12V battery died. Tesla should be able to diagnose remotely.

RT @Carl_Schimenti: Come join us tomorrow! If it adds validity to my resume, My partner @turk727 and I won the @NYSGA1923 4-ball today at L…

@SHAQ @solana Terry Magnuson

SHAQ.SOL got a nice ring to it

@ollie_rando @vera_rinaldi Great work you two! Vera is indeed a force of nature. I loved having her in the lab...her passion for science is unparalleled.

CornellALERT: EVACUATE AND AVOID THE LAW SCHOOL,GOLDWIN SMITH, UPSON HALL AND KENNEDY HALL PLEASE DO NOT CALL THE CORNELL POLICE UNLESS YOU HAVE AN EMERGENCY

@GenomeStability Yup, and the cost! But there's no substitute for functional studies.

@Tcomplex Important work! Must have been disappointing to see so few phenotypes though in all those difficult to generate mice!

A firehose of variants, a few drops of validation.... biorxiv.org/content/10.110…

RT @CornellMBG: Super excited to announce that MBG is searching for TWO new faculty members! Open topic - we're happy to receive applicati…

Quote from Tom Brady on getting older: “You think people care what you think, and then you care less what people think, and then you realize no one cared, anyway.”