Brunello's Lab

Celebrating #PhysiologyWeek with: Load-dependent activation of the myosin filament in the heart doi.org/10.1113/JP2874… physoc.onlinelibrary.wiley.com/doi/full/10.11… @KclPhysiology @esrfsynchrotron @brunello_lab @JPhysiol

Experiments performed @esrfsynchrotron provide new insights into thick filament structure in intact and demembranated cardiac trabeculae from rat hearts.

.@OvejeroScience, Elisabetta Brunello @kingsmedicine and colleagues show that cooling resting or relaxed rat heart muscle releases #myosin motors from the helical folded conformation that inhibits actin interaction in physiological conditions. bit.ly/3HcyxEC #Biophysics

Delighted to share the first publication from my postdoc at @RBiophysics alongside @brunello_lab & @LucaFusi2, where we use time-resolved X-ray diffraction at @I22_DLS to measure changes in the thick filament of mouse EDL muscle during a twitch & tetanus elifesciences.org/articles/68211

A great job opportunity! Really exciting interdisciplinary project in the Brunello lab!!! jobs.kcl.ac.uk/gb/en/job/0242…