Cristhian Cañari Chumpitaz

Online Now: 2′-O-Methylation maintains ribosome structural and translation integrity dlvr.it/TRq573

Apical Localization of RNA Polymerases Modulate Transcription Dynamics and Supercoiling Domains Revealed by Cryo-ET biorxiv.org/content/10.648… #biorxiv_biophys

Unstructured transcription factor interactions enable emergent specificity | @ScienceMagazine science.org/doi/10.1126/sc…

Nature research paper: Exapted CRISPR–Cas12f homologues drive RNA-guided transcription go.nature.com/3P0wiNu

Nature research paper: Structural basis of RNA-guided transcription by a dCas12f–σE–RNAP complex go.nature.com/3MXvicv

In DNA-PAINT, nearby proteins create overlapping localizations. You may see two by eye, but analysis often misses them, wasting precious precision. G5M solves this. Now in @NatureComms: doi.org/10.1038/s41467… 1/7

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life @CellCellPress cell.com/cell/fulltext/…

Amazing paper from @PhilHolliger science.org/doi/10.1126/sc…

Using single-particle cryo-EM on native samples of the human parasite Toxoplasma gondii, we determined structures of four major components of the conoid, its cell-invasion machinery. This project builds on our continued collaboration with the David Sibley lab at WashU.

nature.com/articles/s4159… Huge congrats to our collaborative team for their success achieving "Parallel stopped-flow interrogation of diverse biological systems at the single-molecule scale" rdcu.be/eS2ps An advance in experimental throughput and sensitivity that revealed unexpected results!

Thrilled to share our work on transcription initiation and termination being spatially coordinated out today in Science! science.org/doi/10.1126/sc…

"[W]e communicate...single-molecule characterization of MtbRNAP elongation and its inhibition by three...small-molecule inhibitors: N(α)-aroyl-N-aryl-phenylalaninamide (D-IX216), streptolydigin (Stl), and pseudouridimycin (PUM)" doi.org/10.7554/eLife.…

John Clarke, UC Berkeley emeritus professor, awarded the 2025 #NobelPrize in #Physics. The Nobel Prize committee honored Clarke "for the discovery of macroscopic quantum mechanical tunneling and energy quantization in an electric circuit." bit.ly/46WFHeg

Now online! Single-cell nascent transcription reveals sparse genome usage and plasticity dlvr.it/TNJwXP

Bacillus subtilis σA and Escherichia coli σ70 lacking σ region 1.1 are not released during transcription initiation and elongation (Collaboration with lab of Jayanta Mukhopadhyay.) pnas.org/doi/10.1073/pn…

Now online! Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation dlvr.it/TMmmRP

New online! Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug bit.ly/4mluP07

🎉 Celebrating Jennifer Doudna’s groundbreaking achievements in CRISPR-Cas9 🧬 and RNA research as she receives the 2025 Priestley Medal from the @AmerChemSociety! @UCBerkeley 🏅🔬 Read more ⬇️ newscenter.lbl.gov/2025/08/05/jen…

We’re excited to share new data published in @Nature detailing the impressive activity, specificity, and low immunogenicity of our AI-designed CRISPR-Cas proteins, including OpenCRISPR-1. The future of gene editing is here and we’re scaling our capabilities to tackle the hardest problems that will unlock new medicines.

Now published in Nature Nanotechnology! 🤩 @NatureNano nature.com/articles/s4156…