Alexander A. Morgan, MD PhD
4.7K posts

Alexander A. Morgan, MD PhD
@genomicsdoc
25 years working at the intersection of AI, biotech, and healthcare. Partner at Khosla Ventures, investing in the future.




Infinite mental health services affordable @Limbic_ai. Key finding in Nature Medicine: nature.com/articles/s4159… Limbic Layer™ turns any frontier LLM into a behavioral health specialist, improving therapeutic performance (as judged by other therapists), patient experience, and clinical outcomes. 75% of Limbic's AI sessions ranked among the top 10% of human therapist sessions, demonstrating superior clinical performance in a fully autonomous setting. CBT rated superior to both human clinicians and underlying LLMs

Ken Griffin, founder of Citadel, has a $10 plaque behind his desk that reads: "If we're all going to eat, someone has to sell." Of all the things this man could surround himself with, he chose a cheap plaque with a blunt truth about business. "You're always selling. You're selling to candidates. You're selling to vendors, you're selling to counterparties, you're selling to customers." And if you're always selling, you know what you're going to hear a lot of? "No." Griffin doesn't sugarcoat it. He tells two stories that illustrate just how brutal rejection can be. 1994 was a rough year, with Citadel losing ~4% of its capital. Griffin flew to Switzerland for a crucial lunch meeting, sat down, and his guest arrived only to say: "Oh, I thought you were John Griffin from Fen Church. I got to go." His lunch date got up and left the table. Later that afternoon, a Swiss banker spent 45 minutes with him in a beautiful office, smoking a cigar, before closing with: "Such a pity that such a bright young man picked the wrong career." Two rejections in one day for the founder of one of the most successful hedge funds in history — and his takeaway was simply this: "You just have to tolerate. You're going to hear no a lot, but you need to become accustomed to having to market your ideas and market what you represent and what you stand for." Absorbing rejection and continuing anyway is the actual skill, whether you're hiring, raising capital, or winning customers. Most people avoid selling because they're afraid of no. The ones who build great things have learned to expect it.

Sam Altman explains how to come up with a great startup idea “Wait to have a good idea before you start a startup. If you start a startup without a good idea… you’ll be under pressure to make something up and it won’t work that well. The very best startups are all started because someone believes so passionately in an idea and they believe that a startup is the best way to make that happen.” As Sam explains in the clip below, the hard thing about good ideas is they require original thought. Most people just copy other people’s thoughts, but it’s usually disastrous if you try to copy someone else’s idea. For example, thousands of social media and photo sharing apps were started after Facebook and Instagram, but very few went anywhere. You want to do something that’s new and different. A good way to come up with startup ideas is noticing problems in your own life: “It’s not true that all successful startups are started to solve a problem that the founders have themselves, but it’s a very high percentage. If you go back and think about the transformational companies, most of them start with someone solving their own problem.” Another thing you notice if you go back and look at all the really successful companies is that many of them were early to a massive technology wave. Sam believes these “Great Waves” are why great companies tend to cluster in time (e.g. Amazon and Google with the Internet wave; Uber, Airbnb, Snapchat, Instagram, WhatsApp with the mobile wave; etc.). “A really good question ask is: What is the wave that’s starting right now?” Sam also wrote an essay on this: Idea Generation. Video source: @WaterlooENG (2017)





This 1992 lecture at MIT from Steve Jobs will teach you more about product and sales than most 2 year MBA programs Crazy just how ahead of his time this man truly was





New Uncapped with two of the greats, @vkhosla and @rabois. I don't think I've seen them on a podcast together so I was especially excited about this. I asked them about how they work together, how they see the world, what's changed in tech, and of course a little bit about their politics. Enjoy. (0:00) Intro (0:58) The working relationship (4:26) Pie chart on what’s discussed (7:11) Ethos of investors today vs the past (10:42) Comparing FF and KV (12:46) What makes a great founder (22:56) Alpha in today’s market (30:05) Themes in AI (38:23) How AI companies are built (46:23) Interests outside of AI (53:12) Their politics on X (58:24) Evolution of political leanings







