Pablo M. Garcia-Roves

@davisis79 Many thanks @davisis79 . Proud of Pau. Great dissertation. Many thanks @mardelmala, @AntonioZorzano, @Amaia_777 and @VillenaLab. And special thanks to all our collaborators that contributed to this work doi.org/10.1101/2020.0…

Scientists just mapped human cellular aging at single-cell resolution for the first time. #NIH's SenNet initiative tracked #SenescentCells across the body. A foundation for the next decade of aging research. medicine.yale.edu/news-article/s… #Geroscience #AgingResearch #cellularaging

Excited to be sponsors of #MiP2026 - Challenges of mitochondrial diagnostics, prevention, and therapy, taking place Dec 2-5 in Innsbruck. ⏳ Early bird registration rates are valid until July 1. Info 👉buff.ly/R3tp6dz #Mitochondria #MitoAnalytics #Bioenergetics

New content online: Adipose tissue as a humoral–neuronal hub in metabolic regulation dlvr.it/TT1K68

Mitochondria directly interact with the nuclear pore complex #mitochondria nature.com/articles/s4158…

PI is a prominent #mitochondrial lipid but little is known about its regulation and function. In work led by @Zak_Bakes and Rachel Guerra, we discovered that Fmp30p is a PI hydrolase that affects IM protein organization and CoQ production. #HHMInews #WashU nature.com/articles/s4146…

Functional specialization within the mitochondrial network: Are all mitochondria created equal? dlvr.it/TSxTtm

Review Article ‘Mitochondrial disease: mechanisms, signalling, and therapeutic opportunities’ Corra et al., Free Radic Biol Med (sciencedirect.com/science/articl…) @SFRRAustralasia @SFRR_Europe @SFRBM @Sciencedirect

Decreased degree of adipocyte differentiation in visceral adipose tissue contributes to #MASLD @NatureComms nature.com/articles/s4146…

Good morning, mito lovers! Here is another wonderful selection of papers in #cancermetabolism and #mitochondrialbiology: biomed.news/bims-camemi/20… @Bims_BiomedNews #keepreading "I am not one and simple, but complex and many."-Virginia Woolf

In a paper just published in @sciencemagazine, we teamed up with @teichlab to construct the most detailed atlas to date of hormone production and action in humans at cellular resolution. (1/8) Link: science.org/doi/10.1126/sc…

El ejercicio físico no puede quedarse en un consejo de pasillo. Tiene dosis, indicaciones y mecanismo de acción como cualquier fármaco, y en muchas enfermedades es el mejor tratamiento, no solo el complemento. Prescribirlo no es opcional: es medicina basada en la evidencia. @HoyPorHoy @La_SER @Nunodomin

Glycogen drives the sensory activation of POMC neurons dlvr.it/TSlM90

Universal transcriptomic hallmarks of mammalian ageing and mortality | Nature nature.com/articles/s4158…

Mechanism of age-related accumulation of mtDNA mutations in human blood | Nature nature.com/articles/s4158…

With aging, cells lose their identity and undergo a mesenchymal drift. Reversing this drift may be a way to mitigate aging and promote healthspan. A new @CellCellPress review cell.com/cell/fulltext/…

📌 Take-home: Mitochondrial complex I → redox control → antigen cross-presentation by DCs → CD8⁺ immunity 🚨FREE LINK (for 🚨2000 downloads, PLEASE only use if you have no institutional access): science.org/eprint/MTXDH3X…

30 years ago I was working with elite athletes and drawing training zones on paper based on blood lactate curves. No substrate data. No indirect calorimetry. Just the conviction that something metabolically distinct was happening at each intensity — and that Zone 2 was where the most important adaptation was taking place. In 2005 I began adding fat and carbohydrate oxidation rates to the picture, and what the substrate data revealed confirmed what the lactate curves had been suggesting all along: each intensity represents a distinct metabolic state, not just a point on a continuum of effort. That work became the Metabolic Map in 2013. Then the metabolic flexibility paper with George Brooks in 2018. And now the updated 2026 framework, which maps four metabolic states onto classical threshold models and asks a question the older models never quite posed: Is the system in optimal metabolic balance, or is it drifting away from it? Lactate turns out to be the best real-time proxy we have for answering that question. It tracks metabolic equilibrium, the onset of drift, and the progression toward overload better than any other single variable we can measure in the field. Thirty years of work. One molecule. One central question. My last substack article open.substack.com/pub/inigosanmi…

The POS service manual describes how to perform cathode and anode cleaning, cleaning of electrical connections, and membrane mounting. These steps are essential to ensure signal stability, low noise, and high time-resolution. buff.ly/0wo3DaZ #HighResolutionRespirometry

The big advance in the science of human aging is the ability to quantify it and relate the metrics to health and disease. A new paper today @CellCellPress takes this to the next level with organ clocks and multiple biologic layers (omics) of data across the lifespan. cell.com/cell/fulltext/…

Immune cells regulate circulating adipocyte extracellular vesicle levels in response to metabolic shifts dlvr.it/TSPqjY