Mark R@markrobinsonca@{genomic.social,bsky.social}

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Mark R@markrobinsonca@{genomic.social,bsky.social}

Mark R@markrobinsonca@{genomic.social,bsky.social}

@markrobinsonca

statistical bioinformatics; canadian/swiss; #methodsmatter #rstats; open science advocate; grumpy towards prestige worshippers, excessive admin and bros.

Zurich, CH 가입일 Ekim 2011
722 팔로잉3.5K 팔로워
Mark R@markrobinsonca@{genomic.social,bsky.social} 리트윗함
Lukas Weber
Lukas Weber@lmwebr·
We are excited to share our online book and preprint on “Orchestrating Spatial Transcriptomics Analysis with Bioconductor” (OSTA)!
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Mark R@markrobinsonca@{genomic.social,bsky.social} 리트윗함
🇵🇸 Simone Tiberi 🇵🇸
🇵🇸 Simone Tiberi 🇵🇸@tiberi_simone·
DESpace2: a novel framework to compare spatial expression patterns between conditions (e.g., healthy vs. diseased), from spatial omics data. Aim: identifying genes with distinct spatial structures (DSP) between groups of samples. 1/3
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Mark R@markrobinsonca@{genomic.social,bsky.social}
Guest Editors: Mark Robinson, University of Zurich Fritz Joachim Sedlazeck, Baylor College of Medicine Hong-Bin Shen, Shanghai Jiao Tong University Jean Yee Hwa Yang, The University of Sydney Xin Maizie Zhou, Vanderbilt University
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Mark R@markrobinsonca@{genomic.social,bsky.social} 리트윗함
Malte Luecken
Malte Luecken@MDLuecken·
Looking forward to giving my talk on community-driven benchmarking via Open Problems tomorrow at the first Ascona benchmarking meeting. @markrobinsonca really knows how to put on a conference in this beautiful location! Half of my lab came along :).
Malte Luecken tweet media
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Mark R@markrobinsonca@{genomic.social,bsky.social}
Quick update. We have a pretty exciting lineup of topics/speakers in and around benchmarking that will be presented in Ascona at the end of the month: sites.google.com/view/ascona202… There are few registration slots left, so if you are interested to join us, get in touch.
Mark R@markrobinsonca@{genomic.social,bsky.social}@markrobinsonca

Interested in benchmarking computational methods in computational biology, generally? Save the date, submit an abstract, join us next March in Ascona! Conference website: sites.google.com/view/ascona2025 Please retweet and/or tell your colleagues!

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Mark R@markrobinsonca@{genomic.social,bsky.social} 리트윗함
Siyuan Luo
Siyuan Luo@Siyuan__Luo·
Excited to share our work on selecting validation metrics for single-cell and spatial omics! Learn to evaluate embeddings, graphs, clustering, and spatial domains with biological relevance. Discover poem, our R package with new spatially-aware metrics! doi.org/10.1101/2024.1…
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Mark R@markrobinsonca@{genomic.social,bsky.social}
This is getting exciting. Over 20 abstracts submitted. The committee will be looking at them next week. Looking forward to these discussions. There is still time to submit (due Monday 18th). Google form link: forms.gle/v5FJ21oLcJQokw…
Mark R@markrobinsonca@{genomic.social,bsky.social}@markrobinsonca

Interested in benchmarking computational methods in computational biology, generally? Save the date, submit an abstract, join us next March in Ascona! Conference website: sites.google.com/view/ascona2025 Please retweet and/or tell your colleagues!

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Mark R@markrobinsonca@{genomic.social,bsky.social} 리트윗함
Anshul Kundaje
Anshul Kundaje@anshulkundaje·
biorxiv.org/content/10.110… Nice benchmark of single cell "foundation models" (scGPT, scFoundation) and GEARS (a GNN model) further hyped as "virtual cell models" against linear baselines on perturbation prediction. Long-story short: they can't beat the linear baselines. 1/
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Mark R@markrobinsonca@{genomic.social,bsky.social} 리트윗함
Anshul Kundaje
Anshul Kundaje@anshulkundaje·
Before folks jump to the next level with even bigger, more complex models, can u plz come together with others who have expertise on how to set up benchmarks & baselines to really test whether u r actually making progress? 3/
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Mark R@markrobinsonca@{genomic.social,bsky.social} 리트윗함
Stephen Turner 🦋 @stephenturner.us
Weekly recap: What I'm reading this week in de-extinction and patent law, ATAC-seq benchmarking, large animal genomes, SV genotyping with long reads, cell type-specific enhancer prediction, AI in biosecurity, blog.stephenturner.us/p/weekly-recap…
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Mark R@markrobinsonca@{genomic.social,bsky.social} 리트윗함
🇵🇸 Simone Tiberi 🇵🇸
🇵🇸 Simone Tiberi 🇵🇸@tiberi_simone·
*DifferentialRegulation* out in Biostatistics: doi.org/10.1093/biosta… A Bayesian hierarchical method to identify differences in splicing dynamics (i.e. gene regulation) between conditions. It works on bulk and single-cell RNA-seq. Also on Bioconductor: bioconductor.org/packages/Diffe…
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🇵🇸 Simone Tiberi 🇵🇸@tiberi_simone

DifferentialRegulation pre-print online -> doi.org/10.1101/2023.0… *DifferentialRegulation* studies how splicing dynamics change between experimental conditions. It is based on a Bayesian hierarchical method (multiple samples) with latent states (for multi-mapping reads).

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Mark R@markrobinsonca@{genomic.social,bsky.social} 리트윗함
Maarten Vanhove
Maarten Vanhove@MPM_Vanhove·
Absolutely. To me, Gold OA is one of the most discouraging and wasteful aspects of practising science, propagating enormous inequality, gatekeeping, and Matthew effects.
Alejandro Montenegro@aemonten

The "pay to publish model" has been terrible for sci publishing. And no, it was not initially popularized by commercial publishers. In fact, many publishers, including numerous society ones, would be happy to go back to subs 😅 (with all the problems it also has)

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