Sojunky

@HenrychihangFu1 @Rfonsi1 Would you mind sharing what tool or combination you used to create the cool infographic?

🧬 We used thalidomide for years in myeloma… without knowing why it worked. Not the target. Not the pathway. Just the clinical signal. Now we know—and it’s not chemotherapy. IMiDs are cereblon-directed protein degraders: → Bind CRBN → Degrade IKZF1 (Ikaros) & IKZF3 (Aiolos) From that single mechanism: 🛡️ Immune system ↑ IL-2 ↑ T-cell / NK activation ↓ regulatory T-cell (Treg) function 💥 Tumor cell ↓ IRF4 / MYC → collapse of survival program → cell death 👉 One pathway. Two effects. 👉 Not contradictory—reprogramming biology 🚀 CELMoDs? Same pathway. Stronger signal. → Higher affinity to cereblon → Deeper IKZF1/3 degradation → Activity even after IMiD failure 💡 This is the shift Not: “Does the drug kill the tumor?” But: 👉 “How does it rewire the system?” 👇 Figure: IMiD → immune + tumor effects → CELMoD amplification #myeloma #Hemetwitter