ACR_Journals

Open-label study among newly diagnosed children with systemic JIA or Still disease showed first-line canakinumab showed high efficacy and led to substantial improvements across individual disease activity measures ACR Open Rheumatology doi.org/10.1002/acr2.9…

Nakabo et al show that anti-CarP antibodies stabilize carbamylated histone H3 within NETs, amplifying inflammation, enhancing osteoclast formation, and activating synovial fibroblasts. This uncovers a key link between humoral immunity and joint damage in RA A&R doi.org/10.1002/art.70… @ccarmona17

FcγRIIIA-reporter assay revealed that bioactivity of circulating IC was significantly elevated across systemic autoimmune diseases and was associated with disease activity, particularly in SLE. In SLE, the assay reflected disease activity, identifying risks even in patients with low anti-dsDNA levels A&R doi.org/10.1002/art.70…

People with systemic autoimmune and rheumatic diseases are at higher risk of adverse pregnancy and perinatal outcomes. Narrative review in AC&R describes approaches to reproductive health that provide a potential framework for high-quality care in a rheumatology context doi.org/10.1002/acr.80…

Can lung ultrasound monitor progression of interstitial lung abnormalities in RA? In a prospective pilot study (n=81), baseline B-lines and their change over time independently predicted HRCT progression (AUC 0.78), improving to 0.82 when combined with DLCO and outperforming symptoms and PFTs A&R doi.org/10.1002/art.70… @VermantMarie

Editorial in A&R: Interferon with Still Disease and the Treatment Conundrum By exploring the role for IFN-I in SD and SD-LD, Ombrello and colleagues have advanced the science/knowledge for this rare condition. While many of the correlations were made using a single timepoint analysis of ISG-28 scores in largely refractory SD patients, the genetic underpinnings support a role for IFN-I in a subset of SD individuals doi.org/10.1002/art.70…

Whole-exome seq study of 174 patients with SLE treated with glucocorticoids identified heterozygous variants in ANK1 and EPB41, associated with higher risk of steroid-induced osteonecrosis of the femoral head Arthritis & Rheumatology doi.org/10.1002/art.70…

A 74-year-old man presented with left hip pain. He reported 9-kg weight loss over a year. X-ray revealed erosions of the left greater trochanter (A). MRI of the left hip and thigh showed poorly defined collection contiguous with the erosion, extending to the lesser trochanter, with a thickness of 11 mm (E & F), and a second multiloculated collection 15 cm in length (D) Clinical images in ACROR doi.org/10.1002/acr2.9…

A 52-year-old woman presented with chronic low back pain that had persisted for >10 years. The pain was spontaneous and not associated with tenderness on physical exam. A vascular bruit was audible over the back. Labs did not show elevated CRP or ESR Clinical images in ACROR doi.org/10.1002/acr2.9…

A 75-year-old man presented with lower leg edema. Exam did not show any other abnormal findings. Labs showed elevated IgG4 (441 mg/dL), and contrast-enhanced CT revealed perivascular opacities, retroperitoneal soft tissue lesions, and a double inferior vena cava (fig B) Clinical images in ACROR doi.org/10.1002/acr2.9…

New insights into systemic sclerosis–associated lung disease: LATEST episode explores how peripheral blood gene expression may help predict response to mycophenolate & inform treatment strategies. 🎙️ LISTEN → acr.tw/4c0wFzB

April Arthritis Care & Research Editor's Pick: this study examined factors associated with early PT referrals in patients with incident knee osteoarthritis (KOA). Results showed the rate of physician referrals to PT for a new episode of KOA was low, and that referrals typically occurred at the incident visit doi.org/10.1002/acr.25…

Published this week in ACR Open Rheumatology Smartphone app-based module for RA joint self-assessment doi.org/10.1002/acr2.9… Leflunomide assoc with reduced incidence of tracheal dilations in patients with GPA with tracheobronchial stenosis doi.org/10.1002/acr2.9… Sys review: extracorporeal membrane oxygenation use for life-threatening rheumatic disease complications doi.org/10.1002/acr2.9… Pulmonary function decline in very early diagnosis of SSc doi.org/10.1002/acr2.9… Passive leg movement to assess impairment of NO-mediated vascular function in SSc doi.org/10.1002/acr2.9… Case report: Concurrent LN, Libman-Sacks endocarditis, and optic perineuritis in a patient with SLE doi.org/10.1002/acr2.9…

New studies this week in Arthritis & Rheumatology Phase 3b TOGETHER-PsA trial: ixekizumab + tirzepatide in comorbid overweight or obese adults with PsA doi.org/10.1002/art.70… Whole-genome sequencing in 7,339 Han Chinese people maps serum urate genetics doi.org/10.1002/art.70… Phase 2a trial: guselkumab + golimumab combination for PsA with inadequate TNFi response doi.org/10.1002/art.70… Higher serum concentrations of specific forever chemicals and symptomatic knee OA incidence doi.org/10.1002/art.70… Recovery of Treg by low-dose IL-2 in inflammatory myopathies doi.org/10.1002/art.70… Identifying SLE from serum proteomic profiles using machine learning doi.org/10.1002/art.70…

A 27-year-old woman with history of idiopathic intracranial hypertension presented to the ED with acute left upper extremity weakness and fevers. Weeks prior, she had presented with headaches and blurred vision. Imaging revealed multiple acute & subacute cerebral infarctions (A), a splenic infarct, and bilateral optic perineuritis (B) ACROR doi.org/10.1002/acr2.9…

Using passive leg movement (PLM) to assess impairment of NO-mediated vascular function in 21 patients w/ SSc showed signicantly impaired PLM responses vs controls. There was no assoc. between PLM responses & immunosuppressive or vasoactive agent use ACROR doi.org/10.1002/acr2.9…

Retrospective study of 73 patients with very early diagnosis of systemic sclerosis showed over 5-year follow-up that baseline DLco/single breath % <70% was assoc. with progression toward definite SSc and shorter time to transition; however, decline could also occur without transition to SSc ACROR doi.org/10.1002/acr2.9…

Systematic review examined extracorporeal membrane oxygenation use in patients with life-threatening rheumatic disease complications. 57% (416/734 patients) were successfully bridged to recovery, with highest survival in AAV diffuse alveolar hemorrhage and lowest survival in myositis rapidly progressive ILD ACROR doi.org/10.1002/acr2.9…

Can blood proteins predict lupus before diagnosis? New study using @UK_Biobank data says yes. Machine learning models trained on serum proteomics identified lupus with ~90% sensitivity, outperformed polygenic risk scores, and flagged novel biomarkers. Replicated in independent cohorts from Sweden and China. A&R doi.org/10.1002/art.70…

Single-center retrospective review of patients with GPA who experienced tracheobronchial stenosis (n=56) showed leflunomide treatment was associated with reduced incidence of tracheal dilations ACR Open Rheumatology doi.org/10.1002/acr2.9…