AHA Science

Key updates to this guideline include: ➡️ The use of the American Heart Association PREVENT-ASCVD equations to guide primary-prevention and lipid-lowering therapy decisions. ➡️ Testing Lp(a) at least once in a lifetime and selective apolipoprotein B measurement to improve risk assessment and guide treatment ➡️ The return of LDL-C and non-high-density lipoprotein cholesterol treatment goals (with lower targets for higher-risk groups) ➡️ Expanded use of coronary artery calcium scoring to reclassify risk[ME1.1] ✍🏼 @rblument1 @tygluckman @RonBlankstein @PamelaBMorris @pnatarajanmd @AnnMarieNavar @SethShayMartin @APRN_CNS @nyulangone @DrMichaelShapir @kgradneyrd @eugeniagianos @virani_md @KellieMcLain1 @ijeomaheartdoc @SamiaMoraMD @DrHeatherJohn @dmljmd

Congratulations to @ekoikonomou for receiving an @AHAScience Career Development Award! Evan joined @cards_lab in its 1st year, 6 years ago. Since then, he's defined what rigorous science in AI looks like. His work will focus on targeted discovery of HCM with a novel multimodal AI approach. A great friend, travel buddy, and now Associate Director of CarDS Lab. Couldn't be more deserved!

ICYMI here are results from LBS presentations at #ACC26.

2/ View the paper and supplemental resources here: spr.ly/6014B6Wx3a

Right ventricular (RV) dysfunction is a key determinant of outcomes in pulmonary hypertension and is increasingly recognized in other conditions, including heart failure with preserved ejection fraction, congenital heart disease, cardiomyopathies, acute infection, critical illness, and after left ventricular assist device implantation. Therapeutic strategies are increasingly shifting toward RV–targeted approaches, such as modulation of inflammation, fibrosis, metabolism, and RV-pulmonary artery (PA) uncoupling coupling, highlighting the need for RV–specific endpoints in clinical trials. ✍🏼 @PullamsettiL @sbonnet2 @RRVdpool @Viniciodjperez 📷 Mechanisms driving right ventricular dysfunction in pulmonary hypertension.

2/ View the paper and supplemental resources here: spr.ly/6013B6Wx8T

In pulmonary hypertension (PH), chronic pressure overload can progress from adaptive right ventricular (RV) hypertrophy to maladaptive remodeling, characterized by RV dilation, fibrosis, stiffness, and RV–pulmonary artery uncoupling. This statement summarizes current knowledge on RV dysfunction in PH, emphasizing its mechanisms, clinical relevance, and therapeutic potential. ✍🏼 @PullamsettiL @sbonnet2 @RRVdpool @Viniciodjperez

Read the scientific statement here: spr.ly/6013B6Gpgd

The scientific statement calls for more rigorous and longer-term randomized controlled trials to evaluate the impact of food is medicine on health outcomes; standardization of the foods and interventions applied in FIM programs; and a stepwise research approach, starting with small-scale studies and expanding to real-world implementation.

2/ View the paper and supplemental resources here: spr.ly/6016B6Yv2e

The statement provides a concise update that summarizes food-based cardiovascular health optimization and CVD risk reduction guidance related to features of heart-healthy dietary patterns. The nine features for heart-healthy dietary patterns across the life course are updated with the latest evidence, and apply regardless of where food is procured, prepared, or consumed. This statement updates the Association’s dietary guidance last published in 2021 and reflects the most recent scientific evidence and expert consensus.

2/ View the paper and supplemental resources here: spr.ly/6019B6Yvh7

Published today, 2026 Dietary Guidance to Improve Cardiovascular Health: A Scientific Statement from the American Heart Association. This statement: ➡️ Reinforces the importance of focusing on heart-healthy dietary patterns, rather than on single foods or nutrients. ➡️ Highlights the importance of adopting heart-healthy eating habits early in life and maintaining them across the life course. ➡️ Organizes the guidance into nine features to facilitate adoption of a dietary pattern that support cardiovascular health. ➡️ Recognizes the additional benefits that come with adoption of a heart-healthy dietary pattern beyond CVD. 📷 Features of a dietary pattern to promote cardiovascular health.

✍🏼 @rblument1 @tygluckman @RonBlankstein @PamelaBMorris @pnatarajanmd @AnnMarieNavar @SethShayMartin @APRN_CNS @nyulangone @DrMichaelShapir @kgradneyrd @eugeniagianos @virani_md @KellieMcLain1 @ijeomaheartdoc @SamiaMoraMD @DrHeatherJohn @dmljmd

The 2026 Guideline on the Management of Dyslipidemia was recently published. Here are the top things for pediatric clinicians to know.

PRO-TAVI results presented at #ACC26

SCOUT-HCM results presented at #ACC26

FAST III results presented at #ACC26

ALL-RISE results presented at #ACC26

CHIP-BCIS3 results presented at #ACC26

STEMI-DTU results presented at #ACC26