Transplantation and Cellular Therapy Journal

This perspective article shows that TBF conditioning for #alloHSCT offers potent disease control in acute leukemias and myeloproliferative neoplasms. Dose tailoring therapeutic drug monitoring and patient selection may mitigate toxicity. Read more: ow.ly/ZrwC50YYtGb

Competing risk analyses in #HCT and IEC research are frequently misconstrued. This practical guide outlines correct interpretation of competing risk methods and provides a step-by-step R tutorial for publication-ready analyses figures and tables. ow.ly/oCJ950YYtAZ

This study shows that GNRI CRP and disease status are independent prognostic factors after second allogeneic stem cell transplantation. A novel three-factor scoring system stratified survival outcomes and identified higher non-relapse mortality risk. ow.ly/lLkb50YYtwl

A study finds that decitabine (DAC) conditioning improved natural killer cell maturation and limited CD8+ T cell terminal differentiation post-alloSCT. DAC conditioning potentially may improve graft-versus-tumor immunity in #AML patients. Full study: ow.ly/Ymn750YYtkO

CARE-BMT score predicts early cardiac events after #alloHCT and cyclophosphamide exposure increases risk. Modified model improves identification of cardiovascular risk and may guide cardioprotective strategies. Full article: ow.ly/QnyJ50YVi5Z

Low-dose azacitidine maintenance after #HCT is well tolerated in pediatric high-risk myeloid malignancies with 3-year OS 91% and RFS 73%. Favorable outcomes support prospective study. Read more: ow.ly/s2b250YVi5E

CNS chronic #GVHD manifests as vasculitis-like demyelinating or meningoencephalitic disease with 2.5% incidence and frequent response to immunosuppression. 8 of the 19 patients experienced long-lasting neurologic sequelae. Read more: ow.ly/WSHx50YVi5m

This prospective investigator-initiated clinical study shows that cytokine-induced killer cell infusion post-ASCT demonstrates antitumor activity with minimal toxicity enhances engraftment and T cell function in high-risk NHL: ow.ly/fhxc50YVi4U

Testing of cell and gene therapy products may identify unexpected genetic findings of donor origin requiring differentiation from manufacturing effects. Recommendations define standards for donor consent and disclosure. Read more: ow.ly/suKL50YVi4A

This article shows that additional COVID-19 vaccine doses improve immune response in #HCT and cellular therapy recipients, including those on anti-CD20/38 therapy, with a favorable safety profile. Full study: ow.ly/hEVQ50YQQx2

This meta-analysis of 651 patients finds belumosudil achieves a 60% overall response rate in chronic #GVHD, with strongest responses in GI and joint involvement and manageable safety profile. Read more: ow.ly/y8iv50YQQwL

Many patients with Hodgkin and diffuse large B-cell lymphoma progress while awaiting autologous transplant, highlighting the need to prioritize high-risk cases and reduce wait times in resource-limited settings. Read more: ow.ly/gTRv50YQQwv

This article shows that higher HLA-DRB1 evolutionary divergence is linked to reduced relapse and improved survival after matched unrelated #HCT, supporting its role in enhancing graft-versus-leukemia effects. Read more: ow.ly/sHEP50YQQvI

This review explores in vivo T-cell depletion strategies in #allpHCT, highlighting advances in ATG and PTCy use and the need for high-quality trials to define optimal approaches. Read the full article: ow.ly/zGOA50YQQrb

The RICE score, incorporating recipient age (>60 years), high comorbidities and use of umbilical cord blood, effectively identified patients who benefited from reduced NRM with RIC. This study externally validated the RICE score in a CIBMTR cohort. Read: astctjournal.org/article/S2666-…

First-line treatment of chronic #GVHD continues to be based on corticosteroids, indicating the need for new approaches. Future trials should focus on predictive markers to provide a biological rationale for sequencing treatment options. Full commentary: astctjournal.org/article/S2666-…

Foamy macrophages in bronchiolitis obliterans (BO) bronchioles co-expressed CD68, CD206 and αSMA. Spatial transcriptomics showed increased fibrosis-related gene in BO bronchioles, and macrophage-to-myofibroblast transition may contribute to fibrosis in BO. astctjournal.org/article/S2666-…

Additional COVID-19 vaccine doses can safely enhance humoral immunity in #HCT recipients. Dampened immunity in HCT recipients on anti-CD20/38 improves with more vaccine doses. Read more: astctjournal.org/article/S2666-…

Reduced-intensity conditioning #alloHCT resulted in excellent OS in inborn errors of immunity, with robust long-term donor engraftment in noninfant patients. Immune reconstitution occurred promptly in the majority of patients. Read more: ow.ly/g2UM50YIUi6

This nationwide registry analysis demonstrates that outcomes of second #alloHCT for Adult T-cell leukemia/lymphoma (ATL) remain limited. For relapse, second #alloHCT may be considered for patients whose disease is adequately controlled. Read: ow.ly/eb4650YIU9Z