Ben Lake

A new paper from @DrorLab, @MIPS_Australia uses atomic-level simulations to reveal a molecular mechanism by which a ligand can achieve selectivity between nearly identical receptors, enabling the rational design of targeted drugs. Open access: nature.com/articles/s4158…

Profiling Sulfur(VI) Fluorides as Reactive Functionalities for Chemical Biology Tools and Expansion of the Ligandable Proteome dlvr.it/ShDqkz

Interesting work around creating “PHORCs”, phosphatase recruitment chimeras. There’s soooo much potential in the concept of dephosphorylating proteins, I believe we can do more with such technology over time pubs.acs.org/doi/10.1021/ja…