Blood Advances

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Subpopulations of donor RBCs with low deformability are selectively cleared within 24 hours of transfusion in a murine model. ow.ly/9veK50WfHqx #redcellsironanderythropoiesis #transfusionmedicine

Anti-PF4/heparin and anti-PF4 antibodies can cooperate to induce platelet activation, thrombocytopenia, and thrombus formation. ow.ly/9EBB50WfHp6 #thrombosisandhemostasis

High-risk RUNX1 and STAG2, but not low-risk TET2, mutations selectively expand different compartments of SF3B1-mutant primitive HSPCs. ow.ly/uhFl50WfHnv #myeloidneoplasia

AhR ligand treatment ameliorates CNS GVHD by reducing NF-κB signaling in microglia thereby providing a novel therapeutic target. ow.ly/vs4x50WfGtN #transplantation #immunobiologyandimmunotherapy

Exposure of endothelial cells to serum or IgG from patients with VITT induced TF expression and thromboinflammation. ow.ly/J3CQ50WfGqO #thrombosisandhemostasis #vascularbiology

ED visits by people with SCD declined after the PDMP started, especially after the PDMP mandate began. ow.ly/vRhZ50WfH8M #healthservicesandoutcomes #redcellsironanderythropoiesis

RHOA G17V enhances CD3/CD28-induced NFAT transcriptional activity by binding p300 and enhancing its histone acetyltransferase activity. ow.ly/PRQw50WfH4o #lymphoidneoplasia

miR-150-5p acts as tumor suppressor by repressing the lymphomagenic-driver E2F3, leading to cell cycle disruption in PBL. ow.ly/fXmr50WfH2e #lymphoidneoplasia

A progression signature was found that commonly increased in expression during the progression from patch to plaque and from plaque to tumor. ow.ly/gm6f50WfGXN #immunobiologyandimmunotherapy #lymphoidneoplasia

Zanubrutinib demonstrated reduced risk of progression/death compared to ibrutinib, acalabrutinib, and bendamustine or idelalisib+rituximab. ow.ly/HtOG50WfGUG #lymphoidneoplasia

CD19.CAR+EVs represent a new dynamic biomarker of CAR T-cell activity and contribute to the direct killing of cancer targets. ow.ly/Xehr50WfHjK #genetherapy #immunobiologyandimmunotherapy #lymphoidneoplasia

PEA exerts neuroprotective effects in central nervous system and peripheral neurons and reduces inflammation. ow.ly/GF5N50WfGQe #redcellsironanderythropoiesis

The bedside SaO2/FiO2 ratio is an inexpensive biomarker to assess ACS severity and guide transfer to the ICU. ow.ly/Yqbm50WfGNe #healthservicesandoutcomes #redcellsironanderythropoiesis

Strongest predictor of improvement was baseline score, reinforcing importance of early initiation of treatment to reduce risk of decline. ow.ly/ZUni50WfGKh #clinicaltrialsandobservations #globaladvances #redcellsironanderythropoiesis

Participants with hemophilia B in the 101HEMB01/101HEMB02 studies failed to achieve plasma FIX levels of 20 IU/dL with DTX101 treatment. ow.ly/KWHW50WfGFS #clinicaltrialsandobservations #genetherapy

The prognostic role of early metabolic response is independent from the type of induction therapy and maintenance therapy. ow.ly/7Wc350WfGzV #clinicaltrialsandobservations #lymphoidneoplasia

A comparison between interventions that will be sought by providers and patients undergoing intervention requires uniform assessments that evaluate disease- and intervention-related effects for informed decision-making. ow.ly/45Or50WfGmr #healthservicesandoutcomes

T-cell receptor therapies are a promising modality for the treatment of cancers, with significant efforts being directed toward acute myeloid leukemia, a particularly challenging disease. ow.ly/WwVJ50WfGfG #immunobiologyandimmunotherapy #myeloidneoplasia

Venous thromboembolism, which includes deep vein thrombosis and pulmonary embolism, represents a complex pathological process extending far beyond inflammatory mechanisms. ow.ly/mJTu50WfG1P #thrombosisandhemostasis

Congenital or hereditary thrombotic thrombocytopenic purpura is a rare autosomal recessive disease caused by biallelic severe defects in the ADAMTS13 gene, either homozygous or compound heterozygous. ow.ly/K1gM50WfFY5 #thrombosisandhemostasis