Sergej Djuranovic

Together with Chun Kan Chen's and @slavicaPD groups we have recently optimized our RAPPL method for the isolation of ribosomes and ribosome fragments from biopsies (5-10mg), tissues (1-5mg) and small blood samples (100-500ul). Soon more on RAPPL Ribo-Seq... Images from ribosome isolation from 100ul of blood, RAPPL-RiboSeq reads and comparison of low expression genes with RAPPL RiboSeq on 250K cells with 10 million cells with classical method. Pending patent #63/694,196 (WU Ref No. 020910/US) nature.com/articles/s4146…

Excited to share the first paper from our new lab @UTSWMedCenter @UTSWScience ! 🎉 Now out in @NatureComms Mechanisms of human mitochondrial leaderless mRNA translation initiation nature.com/articles/s4146…

4 years after terrible loss (two -80C freezers and back-ups) of almost all of our collection of regular and mutant human, Drosophila, E. Coli and Plasmodium cells, and a big hustle with insurance we are going to publish first manuscript that was hindered by this loss. Additional 2 manuscripts are on the way as well. Lot of repeated experiments, use of additional resources and lot of lost nerves over the last 4 years that could have been avoided. This was a valuable collection of mutant cell lines as well as CRISPR/Cas9 engineered lines with endogenously tagged-RBPs, translation factors, ribosomal proteins and other proteins. More than 50% of engineered Plasmodium cells are still not recovered. My suggestion to everyone is to keep some of your most valuable cell lines and back-ups in your collaborators freezers or at least in different buildings or towns.

@pmilonma @slavicaPD let us know if you need most updated protocols.

@DjuranovicLab @slavicaPD Congrats dude!!! Looking forward to test them on the southern side of the world!

Our RAPPL international patent application has just been published. @slavicaPD

Visit from a friend and great colleague from Newcastle University. Sergey Melnikov will after snowy February in Providence talk tomorrow about hibernating ribosomes. Another talk at Brown RNA Center. #ribosomes #RNA

Together with Chun Kan Chen's and @slavicaPD groups we have recently optimized our RAPPL method for isolation of ribosomes and ribosome fragments from biopsies (5-10mg), tissues (1-5mg) and small blood samples (100-500ul). Soon more on RAPPL Ribo-Seq... Images from ribosome isolation from 100ul of blood, RAPPL-RiboSeq reads and comparison of low expression genes with RAPPL RiboSeq on 250K cells with 10 million cells with classical method . nature.com/articles/s4146…

@DjuranovicLab welcomes new postdoctoral fellow @SiddikAlom19 from OSU and @FredrickLabOSU More ribosome research to come soon.

A few months ago (Sep 30th of 2025) @uspto granted yet another one of my patents on how to modulate translation efficiency by changing first 5 codons/amino acids. The origin of this patent is the work from the lab that was published back in 2019 in Nature Communications. Soon we'll have more on this... nature.com/articles/s4146…

Great visit and lot of fun with Yury Polikanov this week at Brown RNA Center

Great collaboration with @CarpeRibosomam and @slavicaPD labs on using MPRAs to look into non-coding mutations. Approaches for identification of 5′ UTR mutations impacting translation and protein production from neurodevelopmental disorder genes: Cell Reports Methods cell.com/cell-reports-m…

@sl and Jessey Erath's view on new Plasmodium ribosome CryoET structures Seeing is believing—Plasmodium falciparum translation in action sciencedirect.com/science/articl…

@slavicaPD and Jessey Erath's view on new Plasmodium ribosome structures. Seeing is believing—Plasmodium falciparum translation in action sciencedirect.com/science/articl…

@IsraelF96135088 Are you accepting people? Or inviting...

University breakfast in Bilbao…

It was great to be there. Looking forward to more such meetings!

On the way back from one week of great science, technology and therapeutic potentials of RNA in organization of @ImmaginaBiotech . Thanks for the great meeting to Max and the Immagina team. Looking forward to future collaborations. #RNA #tRNA #ribosome

We are hiring…position suitable for PhD student with interest in ribosomes, antibiotics and cryoEM… uni-hamburg.de/en/stellenange…

Jessey Erath, a former member of @DjuranovicLab and current investigator in @slavicaPD lab is going to present novelties with RAPPL at @ImmaginaBiotech meeting in Trento...#rna #mRNA #ribosome #RNASeq

We’re excited to welcome Prof. Jody Puglisi (Stanford University) to session 2 of the RNA Symposium, where he’ll present “Translational fidelity.” Explore his work on RNA structure & translation dynamics here: zurl.co/sL9tm #RNA #ribosome #ImmaginaRNA25