Alexandre Escande

5/7 The patient voice was striking. Round 4: patient representatives gave 100% consensus to OS, pPFS, STFS, and PFS — then added time-to-deterioration of quality of life as a primary endpoint. Patients said: measure how we feel, not just how long we last.

Concurrent Versus Sequential Radiation Dose Escalation to the Surgical Cavity for Conservative Treatment of High-Risk Early Breast Cancer: NRG/RTOG 1005 Phase III Trial | Journal of Clinical Oncology ascopubs.org/doi/abs/10.120…

New in #practicalRO: A Practical Distributed Virtual Bolus Strategy for Motion-Robust Superficial Dose Delivery in Breast VMAT. #radonc tinyurl.com/proqqmeng

Neurocognition after brain irradiation: dose-volume effects and regional radiosensitivity − a systematic review by the ESTRO CNS focus group - ScienceDirect sciencedirect.com/science/articl…

New in #practicalRO: SPICE It Up: Technical Report of Hotspot Design for Volumetric Modulated Arc Therapy SBRT in Early-Stage Non-Small Cell Lung Cancer. #radonc tinyurl.com/probajohnson

Artificial intelligence in academic writing #research #academicchatter

Incidence of PTSD after Major Oncology Surgery Site wise Prevalance + RISK Factors

للمهتمين بالبحث العلمي 📚 هذه من أفضل الأوراق اللي قرأتها عن كتابة ونشر الأبحاث. 👌 3 محررين من مجلات طبية كبرى يشرحون بشكل عملي ماذا يريد المحرر فعلًا من الباحث، وأبرز الأخطاء اللي تسبب رفض الورقة. مفيدة جدًا لأي شخص يبدأ بالنشر العلمي أو يطور طريقة كتابته للأبحاث.

Excited to share our prospective randomized phase II study of SBRT in LAPC. Although early closure limited definitive conclusions, SBRT showed numerically higher response and local control with 1-year local progression rates of 11.1% vs 39.1%. rdcu.be/fhYl2

10-yr Survival and Toxicity Outcomes of Stereotactic Body Radiotherapy for Prostate Cancer: A Nonrandomized Clinical Trial - European Urology europeanurology.com/article/S0302-…

New meta-analysis on prognostic factors after radical cystectomy in bladder cancer (77 studies): ❌ Worse OS: advanced age, female sex, pT stage, LN involvement, LVI, positive margins, CIS ✅ Better OS: neoadjuvant & adjuvant chemo, pentafecta compliance Evidence-based foundation for postoperative risk stratification 👇 sciencedirect.com/science/articl… #BladderCancer

Escalated dose ( SIB or brachy) shows improvement in MFS for high risk prostate cancer in this meta analysis thegreenjournal.com/article/S0167-…

How should we manage patients with advanced prostate cancer who refuse ADT? Kerry Schaffer and I share a potential approach to the care of ADT-hesitant patients. @VUMCDiscoveries @Hopkins_HemOnc @hopkinskimmel @PCF_Science @PCFnews #pcsm nature.com/articles/s4158…

📌Validation of IBS-GEC ESTRO-ABS CT Based Contouring Recommendations using Pre-Brachytherapy MRI in Cancer Cervix Patients Treated with Definitive Radiotherapy 🔗 sciencedirect.com/science/articl… @ASTRO_org @HBCHRC_Punjab @DrShinghal @TMC_Varanasi 👉🏻 One of the largest series that compared CT and MR-based contouring using hybrid-interstitial applications in all patients for validating IBS-GEC ESTRO-ABS guidelines in MRDG – PreBTMR and CTBT environment. 👉🏻 CT based contouring using IBS-GEC ESTRO-ABS recommendations with MRI at diagnosis and brachytherapy, is safe, convenient and addresses logistic issues in institutions, especially LMICs.

Priority Editorial! When Patients Refuse Radical Cystectomy: Integrating Trimodality Therapy in the Perioperative ICI/ADC Era by Martino Pedrani et al Read the full article: buff.ly/n6uKXj0 We thank the authors for their insight. @PedraniMartino @DeGiorgiAlberto @AndreaGallina5 @UrsulaVogl @ZilliThomas @uroweb @mroupret @GPloussard @jteoh_hk @Ric_Campi @CaPsurvivorship @LauraMarandino @RenuEapen @Ecastromarcos @OncoAlert @Sciencedirect

The entire @Sunnybrook spine #SBRT team has come together to share 17 years of research and clinical observations in this review for @NatRevClinOncol. We are a true multidisciplinary team that have had a singular focus to develop the technique and evidence nature.com/articles/s4157…

SBRT for High-risk Localised Prostate Cancer: SHARP and the Limits of Non-randomised Evidence - PubMed pubmed.ncbi.nlm.nih.gov/42070918/

Read this #RedJournal article about a prospective phase 2 trial of renal SBRT demonstrating modest decline in renal function following treatment and excellent cancer control rates @r_glicksman @JA_Helou @UroOncMD @RHamiltonUrol @aleberlin2 @onconeph @radmedPM @UofTDRO @UHN_Research tinyurl.com/rjglicksman

HNSCCUP: Involved neck only RT results in low rates of primary site emergence and CLNF, reduced toxicity and no difference in OS compared to mucosal RT. 195 patients, largest series in HPV and FDG PET-CT era. Read about it in the #RedJournal @claire_paters0n @onctrainees @UofGMVLS tinyurl.com/patersonrj

InPACT PART 2 A nodal atlas for penile cancer 1. Neoadj Setting 2. Postoperative = No PLND 3.Postopwrative = With PLND